Abstract
Proto-oncogenes the cellular homologues of retroviral oncogenes, appear to be normal cellular genes presumed to play a role in normal cellular processes like growth control and cellular differentiation. Their role in controlling cellular growth is strongly supported by the findings that several proto-oncogenes code for proteins closely related or identical to growth factors or growth factor receptors. It has been also found that the expression of proto-oncogenes c-myc and c-myb is diminished and the expression of c-fos is induced during differentiation of HL60 and U-937 cells (Mitchell 1985).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Augusti-Tocco, G. and Sato, G. (1969) Establishment of functional clonal lines of neurons from mouse neuroblastoma. Proc.Natl.Acad.Sci. USA 64; 311–315
Aviv, H. and Leder, P. (1972) Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc.Natl.Acad.Sci. USA 69; 1408–1412
Bernstine, E. G., Hooper, M. L., Grandchamp, S. and Ephrussi, B. (1973) Alkaline phosphatase activity in mouse teratoma. Proc.Natl.Acad.Sci. USA 70; 3899–3903
Brugge, J. S., Cotton, P. C., Queral, A. E., Barrett, J. N., Nonner, D. and Keane, R. W. (1985) Neurones express high levels of a structurally modified, activated form of pp60-c-src. Nature (London) 316; 554–557
deLorbe, W. J., Lueiv, P. A., Godman, H. M., Varmus, H. E. and Bishop, J. M. (1980) Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J.Virol. 36; 50–61
Harvey, R. P., Krieg, P. A., Robins, A. J., Coles, L. S. and Well, J. R. E. (1981) Non-tandem arrangement and divergent transcription of chicken histone genes. Nature (London) 294; 49–53
Jakob, H., Bonn, T., Gaillard, J., Nicolas, J-F. and Jacob, F. (1973) Teratocarcinome de la Souris, Isolement, Culture et Proprietes de Cellules a Potentialites Multiples. Ann. Microbiol. Inst. Pasteur 124B; 269–282
Minty, A. J., Caravatti,M., Robert, B., Cohen, A., Daubas, P., Weydert, A., Gros, F. and Buckingham, M.E. Mouse actin messenger RNAs. J.Biol.Chem. 256; 1008–1014
Mitchell, L. R., Zokas, L., Schreiber, R. D. and Verma, I. M. (1985) Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation Cell 40; 209–217
Nau, M. M., Brooks, J. B., Battey, J., Sausville, E., Gazdar, A. F., Kirsch, I. R., McBride, O. W., Bertness, V., Hollis, G. F. and Minna, J. D. (1985) L-myc, a new myc related gene amplified and expressed in human small cell lung cancer Nature 318; 69–73
Pfeiffer, S. E., Jakob, H., Mikoshiba, K., Dubois, P., Guenet, J. L., Nicolas, J-F. Gaillard, J., Chevance, G. and Jacob, F. (1981) Differentiation of a teratocarcinoma line: preferential development of cholinergic neurons. J.Cell.Biol. 88; 57–66
Schibler, U., Hagenbüchle, O., Wellauer, P. K. and Pittet, A. C. (1983) Cell 33; 501–508
Schwab, M., Varmus, H. E. and Bishop, J. M. (1985) Nature 316; 160–162
Sejersen, T., Sumegi, J. and Ringertz, N. R. (1985) Expression of cellular oncogenes in teratoma derived cell lines. Exptl.Cell.Res. 160; 19–30
Stanton, L. W., Watt, R. and Marcu, K. B. (1983) Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature (London) 303; 401–406
Strickland, S. and Madhavi, V. (1978) The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell 15; 393–403
Sumegi, J., Spira, J., Bazin, H., Szpirer, J., Levan, G. Klein, G. (1983) Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation. Nature 306; 497–499
Thiele, C. J., Reynolds, C. P. and Israel, M. A. (1985) Decreased expression of N-myc precedes retinoic acid induced morphological differentiation of human neuroblastoma. Nature 313; 404–406
Thomas, P. S. (1980) Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose Proc.Natl.Acad.Sci. USA 77; 5201–5205
Zimmerman, K. A., Yaneopoulus, G. D., Collum, R. G. Smith, R. K. Kohl, N. E. Denis, K. A., Nau, M. M., Witte, O. N., Toran-Allerand, D., Gee, C. E., Minna, J. D. and Alt, F. W. (1986) Differential expression of myc family genes during murine development. Nature 319; 780–780
Tilgham, S. M., Juiyssus, D., Gorin, M. B., Ruiz, J. P. G. and Ingram, R. S. (1979) The presence of intervening sequences in the alpha-fetoprotein gene of the mouse J.Biol.Chem. 254; 7393–7399
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Sumegi, J., Sejersen, T., Björklund, H., Klein, G., Ringertz, N.R. (1986). Differential Expression of N-myc, c-myc and c-src Proto-oncogenes During the Course of Induced Differentiation of Murine Embryonal Carcinoma Cells. In: Melchers, F., Potter, M. (eds) Mechanisms in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71562-4_44
Download citation
DOI: https://doi.org/10.1007/978-3-642-71562-4_44
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71564-8
Online ISBN: 978-3-642-71562-4
eBook Packages: Springer Book Archive