Abstract
It is now thought that most human and animal tumors are caused by environmental factors such as chemical pollutants. However, a small number of animal tumors are known to be caused by viruses. The most common oncogenic viruses are the RNA-containing oncoviruses which are usually contagious and cause lymphoid tumors or sarcomas in young animals. Most of the tumors caused by oncoviruses in animals are viral producers, that is, the causative oncovirus is expressed and can be readily detected in the tumor tissue (Hardy 1978). However, some of the lymphosarcomas (LSA) of pet cats that are caused by the feline leukemia virus (FeLV) exhibit no evidence of FeLV infection even though, as will be clear from the data presented below, FeLV appears to be the etiologic agent for these viral nonproducer (NP) LSAs (Francis et al. 1979; Hardy et al. 1980).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
De-Thé G (1977) Viruses as causes of some human tumors? Results and prospectives of the epidemiologic approach. In: Hiatt HH, Watson JD, Winsten JA (eds) Origins of human cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 1113–1131
Essex M, Klein G, Snyder SP, Harrold JB (1971) Correlation between humoral antibody and regression of tumours induced by feline sarcoma virus. Nature 233:195–196
Francis DP, Cotter SM, Hardy WD Jr, Essex M (1979) Comparison of virus-positive and virus-negative cases of feline leukemia and lymphoma. Cancer Res 39:3866–3870
Gallo RC, Saxinger WC, Gallagher RE, Gillespie DH, Aulakh GS, Wong-Staal F (1977) Some ideas on the origin of leukemia in man and recent evidence for the presence of type-C viral related information. In: Hiatt HH, Watson JD, Winsten JA (eds) Origins of human cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 1253–1285
Goudeau A, Maupas P, Coursaget P, Drucker J, Chiron JP, Denis F, Diop Mar I (1979) Hepatitis B virus antigens in human primary hepatocellular carcinoma tissues. Int J Cancer 24:421–429
Hardy WD Jr (1978) Epidemiology of primary neoplasms of lymphoid tissues of animals. In: Twomey JJ, Good RA (eds) The immunopathology of lymphoreticular neoplasms. Plenum, New York, pp 129–180
Hardy WD Jr, Hirshaut Y, Hess P (1973a) Detection of the feline leukemia virus and other mammalian oncornaviruses by immunofluorescence. In: Dutcher RM, Chieco-Bianchi L (eds) Unifying concepts of leukemia. S. Karger, Basel, pp 778–799
Hardy WD Jr, Old LJ, Hess PW, Essex M, Cotter S (1973b) Horizontal transmission of feline leukaemia virus. Nature 244:266–269
Hardy WD Jr, Zuckerman EE, MacEwen EG, Hayes AA, Essex M (1977) A feline leukaemia virus- and sarcoma virus-induced tumour-specific antigen. Nature 270:249–251
Hardy WD Jr, McClelland AJ, Zuckerman EE, Snyder HW Jr, MacEwen EG, Francis DP, Essex M (1980) The immunology and epidemiology of feline leukemia virus non-producer lymphosarcomas. In: Essex M, Todaro GJ, zur Hausen H (eds) Viruses in naturally occurring cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor pp 677–697
Poiesz, BJ, Ruscetti F, Gazdar AF, Bunn PA, Minna JD, Gallo RC (to be published) Isolation of type-C retrovirus particles from cultured and fresh lymphocytes of a patient with cutaneous T cell lymphoma. Proc Natl Acad Sci USA
Snyder HW Jr, Hardy WD Jr, Zuckerman EE, Fleissner E (1978) Characterization of a tumour-specific antigen on the surface of feline lymphosarcoma cells. Nature 275:656–658
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hardy, W.D. et al. (1981). Feline Leukemia Virus Nonproducer Lymphosarcomas of Cats as a Model for the Etiology of Human Leukemias. In: Neth, R., Gallo, R.C., Graf, T., Mannweiler, K., Winkler, K. (eds) Modern Trends in Human Leukemia IV. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67984-1_90
Download citation
DOI: https://doi.org/10.1007/978-3-642-67984-1_90
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-10622-7
Online ISBN: 978-3-642-67984-1
eBook Packages: Springer Book Archive