Abstract
Safrole, a hepatocarcinogen, is converted by the microsomal mono-oxygenase system to a reactive intermediate which interacts with cytochrome P-450 to form a ligand complex. The formation of this complex is accompanied by loss of mono-oxygenase activity. The present study describes the interaction of the safroie reactive intermediate with microsomes from phenobarbital, 3-methylcholanthrene and safrole pretreated animals.
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Delaforge, M., Ioannides, C., Parke, D.V. (1980). Ligand Binding of Safrole to Cytochrome P-450. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_9
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DOI: https://doi.org/10.1007/978-3-642-67729-8_9
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