Abstract
The effect of single doses of TCDD (1.2, 6 or 30 γ/kg) on several immune parameters has been investigated in young adult C57B1/6 mice. TCDD profoundly suppressed the primary and secondary humoral response to T-dependent (sheep erythrocytes, SRBC) and T-independent (Type III pneumococcal polysaccharide, S III) antigens. In vitro lymphoproliferative responses to Concanavallin A (Con A) and bacterial lypopolysaccharide (LPS), and macrophage and natural killer (NK) cell-mediated cytotoxicity were not significantly affected per unit number of lymphoid cells. Moreover, the ability of splenocytes from TCDD treated animals to mediate a graft versus host (GVH) reaction was not impaired.
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Vecchi, A., Mantovani, A., Sironi, M., Luini, W., Spreafico, F., Garattini, S. (1980). The Effect of Acute Administration of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on Humoral Antibody Production and Cell-Mediated Activities in Mice. In: Chambers, P.L., Klinger, W. (eds) Further Studies in the Assessment of Toxic Actions. Archives of Toxicology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67729-8_35
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DOI: https://doi.org/10.1007/978-3-642-67729-8_35
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