Abstract
The pyrrolo(1,4)benzodiazepine antibiotics are a group of structurally closely related antitumor agents that include anthramycin, tomaymycin, sibiromycin, and the neothramycins A and B (Fig. 1). Biosynthetic studies have been carried out primarily on anthramycin, tomaymycin, and sibiromycin (L.H. Hurley, 1977). The purpose of this review is to present a comprehensive, up-to-date account of both the published work and more recent studies aimed at elucidating the general biosynthetic pathways which lead to these antibiotics. A more general review on the chemistry, biosynthesis, mechanism of action, biological effects, and toxicities of these antibiotics has appeared (L.H. Hurley, 1977).
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Hurley, L.H., Speedie, M.K. (1981). Pyrrolo(1,4)benzodiazepine Antibiotics: Anthramycin, Tomaymycin, and Sibiromycin. In: Corcoran, J.W. (eds) Biosynthesis. Antibiotics, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67724-3_12
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DOI: https://doi.org/10.1007/978-3-642-67724-3_12
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