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Liver Malignancies pp 255–274Cite as

Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

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Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Hepatocellular carcinoma (НСС) is associated with liver cirrhosis in 80% of cases and when the tumor is diagnosed, the very poor hepatic function, due to the underlying liver disease, is so frequent that extended surgical resection is contraindicated in most cases. Because of the poor prognosis of nonresectable HCC, an aggressive approach is justified. Systemic or intraarterial chemotherapy has been used for years but has such a poor objective response rate in any of the large reported series that it has almost been abandoned. At the same time, the treatment of HCC by transcatheter arterial embolization (TAE) of the hepatic artery (ROCHE 1978) and then by combina­tion of occlusion and regional chemotherapy (transcatheter hepatic arterial chemoembolization, TACE) has been investigated and developed since the 1970s. In the early 1980s, the ability of Lipiodol to selectively target hepatic tumors when injected intraarterially was reported by Japanese authors and developed as a complementary therapeutic tool; and nowadays transcatheter hepatic arterial treatments such as TAE, TACE, Lipiodol-TACE (L-TACE) or Lipiodol chemotherapy (L-TAC) play an important role in the therapeutic management of НСС.

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Authors and Affiliations

  1. Interventional Radiology Section, Institut Gustav-Roussy, 39 rue Camille Desmoulins, F-94800, Villejuif, France

    A. Roche MD (Professor)

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  1. Division of Diagnostic and Interventional Radiology, Department of Oncology, University of Pisa, Via Roma 67, I-56125, Pisa, Italy

    C. Bartolozzi MD (Professor and Chairman) & R. Lencioni MD (Professor and Chairman) & 

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Roche, A. (1999). Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma. In: Bartolozzi, C., Lencioni, R. (eds) Liver Malignancies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58641-5_17

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