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Cytogenetics of Abortions

  • Chapter
Comparative Aspects of Reproductive Failure

Abstract

The occurrence of chromosome anomalies in plants and invertebrate animals has been known for many years. In these organisms, various disorders, including the presence of extra chromosomes, have been shown to produce abnormal phenotypes, diminished fertility and increased pollen abortion (Burnham, 1962; Swanson, 1963). Early in 1959, the first chromosome anomalies in man were described. Each was associated with a clearly defined phenotype (Lejeune et al., 1959; Jacobs and Strong, 1959; Ford et al.,1959). In each of these three syndromes, affected individuals presented certain anomalies and diminished fertility but they did not always lead to early death. When lethal chromosome anomalies were demonstrated in newborn infants it was a logical step to study the chromosomes in cases of intrauterine death (Edwards et al., 1960; Patau et al., 1960). Further interest in this subject was stimulated by the description of two abortuses with triploidy (Penrose and Delhanty, 1961; Delhanty et al., 1961). These findings provided the background which led to the study of a large series of spontaneous abortions in man.

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Authors and Affiliations

  1. Health Sciences Centre, University of Western Ontario, London, Ontario, Canada

    D. H. Carr

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  1. D. H. Carr
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Editors and Affiliations

  1. Department of Pathology, Dartmouth Medical School, Hanover, N.H., USA

    Kurt Benirschke

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© 1967 Springer-Verlag New York Inc.

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Carr, D.H. (1967). Cytogenetics of Abortions. In: Benirschke, K. (eds) Comparative Aspects of Reproductive Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48949-5_4

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  • DOI: https://doi.org/10.1007/978-3-642-48949-5_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-48951-8

  • Online ISBN: 978-3-642-48949-5

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