Abstract
The public health impact of addiction, with its high relapse rates and the limited efficacy of available treatments, has prompted the search for alternative therapeutic approaches. In recent times, there has been renewed interest in the anti-addictive potential of psychedelics. Consumption of ayahuasca, the N,N-dimethyltryptamine-containing Amazonian plant tea, is experiencing unprecedented expansion. The ritual use of this brew, obtained from Banisteriopsis caapi and Psychotria viridis, in shamanistic and religious contexts is now popular in Europe and North America. Studies of long-term ayahuasca-church members in Brazil have recorded discontinuation of drug use after starting ayahuasca use. Furthermore, several centers that offer therapies based on ayahuasca as a means to treat addictive behavior claim higher success rates than more traditional approaches. In this chapter, we review the pharmacology of ayahuasca and the data available concerning its efficacy in the treatment of drug addiction. Although the therapeutic potential of ayahuasca, based on the evidence examined, is promising, the lack of systematic studies precludes firm conclusions. Ideally, research methodology should be improved, with future studies implementing well-planned clinical protocols with adequate controls, end-points, and follow-up.
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References
Barbanoj, M. J., Riba, J., Clos, S., Giménez, S., Grasa, E., & Romero, S. (2008). Daytime ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers. Psychopharmacology (Berl), 196(2), 315–326.
Barbosa, P. C., Giglio, J. S., & Dalgalarrondo, P. (2005). Altered states of consciousness and short-term psychological after-effects induced by the first time ritual use of ayahuasca in an urban context in Brazil. Journal of Psychoactive Drugs, 37(2), 193–201.
Barbosa, P. C., Cazorla, I. M., Giglio, J. S., & Strassman, R. (2009). A six-month prospective evaluation of personality traits, psychiatric symptoms and quality of life in ayahuasca-naïve subjects. Journal of Psychoactive Drugs, 41(3), 205–212.
Barbosa, P. C., Mizumoto, S., Bogenschutz, M. P., & Strassman, R. J. (2012). Health status of ayahuasca users. Drug Test Analysis, 4(7–8), 601–609. doi:10.1002/dta.1383.
Beyer, Stephan. V. (2009). Singing to the plants: A guide to mestizo shamanism in the upper Amazon. Albuquerque: University of New Mexico Press.
Bouso, J. C., & Riba, J. (2011). An overview of the pharmacology and neuropsychiatric effects of long term use of ayahuasca. In R. G. Santos (Ed.), The ethnopharmacology of ayahuasca (pp. 55–63). Kerala, India: Transworld Research Network. Ebook retrieved June 30, 2012 from http://www.trnres.com/ebook/uploads/rafael/T_12998350813%20Rafael.pdf.
Bouso, J. C., González, D., Fondevila, S., Cutchet, M., Fernández, X., Ribeiro Barbosa, P. C. et al. (2012). Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of ayahuasca: A longitudinal study. PLoS ONE, 7(8), e42421. DOI: 10.1371/journal.pone.0042421.
Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives of General Psychiatry, 50(12), 975–990.
CONAD. (2010). Resolução nº 01 do Conad, de 25 de janeiro de 2010. Retrieved June 30, 2012 from: http://portal.mj.gov.br/services/DocumentManagement/FileDownload.EZTSvc.asp?DocumentID={B233B4FE-F67B-4D44-911B-962329DA3D47}&ServiceInstUID={74624DEB-0C14-4B3A-B8F3-CD26DEF53FC1}.
Crumbaugh, J. C., & Maholick, L. T. (1976). The purpose in life test. Murfreesboro, TN: Psychometric Affiliates.
Da Silveira, D. X., Grob, C. S., de Rios, M. D., Lopez, E., Alonso, L. K., Tacla, C., et al. (2005). Ayahuasca in adolescence: A preliminary psychiatric assessment. Journal of Psychoactive Drugs, 37(2), 129–133.
de Araujo, D. B., Ribeiro, S., Cecchi, G. A., Carvalho, F. M., Sanchez, T. A., Pinto, J. P., et al. (2011). Seeing with the eyes shut: Neural basis of enhanced imagery following ayahuasca ingestion. Human Brain Mapping, 33(11), 2550–2560. DOI: 10.1002/hbm.21381.
Derogatis, L. R. (2001). Cuestionario de 90 síntomas (SCL-90-R). Madrid: TEA Ediciones, S.A.
Doering-Silveira, E., Lopez, E., Grob, C. S., de Rios, M. D., Alonso, L. K., Tacla, C., et al. (2005a). Ayahuasca in adolescence: A preliminary psychiatric assessment. Journal Psychoactive Drugs, 37(2), 123–128.
Doering-Silveira, E., Grob, C. S., de Rios, M. D., Lopez, E., Alonso, L. K., Tacla, C., et al. (2005b). Report on psychoactive drug use among adolescents using ayahuasca within a religious context. Journal of Psychoactive Drugs, 37(2), 141–144.
dos Santos, R. G. (2011). Ayahuasca: Physiological and subjective effects, comparison with d-amphetamine, and repeated dose assessment (Doctoral dissertation). Universitat Autònoma de Barcelona - UAB, Dep. Farmacologia, Terapèutica i Toxicologia, Barcelona. Retrieved June 30, 2012 from https://www.educacion.gob.es/teseo/mostrarRef.do?ref=959049.
dos Santos, R. G., Grasa, E., Valle, M., Ballester, M. R., Bouso, J. C., Nomdedéu, J. F., et al. (2012). Pharmacology of ayahuasca administered in two repeated doses. Psychopharmacology (Berl), 219(4). 1039–1053.
dos Santos, R. G., Valle, M., Bouso, J. C., Nomdedéu, J. F., Rodriguez-Espinosa, J., McIlhenny, E. H., et al. (2011). Autonomic, neuroendocrine, and immunological effects of ayahuasca: A comparative study with d-amphetamine. Journal of Clinical Psychopharmacology, 31(6), 717–726.
Elkins, D. N., Hedstrom, L. J., Hughes, L. L., Leaf, J. A., & Saunders, C. (1988). Toward phenomenological spirituality: Definition, description, and measurement. The Journal of Humanistic Psychology, 28(4), 5–18.
Fábregas, J. M., González, D., Fondevila, S., Cutchet, M., Fernández X., Barbosa, P. C., et al. (2010). Assessment of addiction severity among ritual users of ayahuasca. Drug and Alcohol Dependency, 111(3), 257–261.
Fernández, X., & Fábregas, J. M. Experience of treatment with ayahuasca for drug addiction in the Brazilian Amazon. In this volume.
Fernández, X., dos Santos, R. G., Cutchet, M., Fondevila, S., González, D., Alcázar, M. A., et al. Assessment of the psychotherapeutic effects of ritual ayahuasca use on drug dependency: A pilot study. In this volume.
Golden, C. J. (1994). Stroop, test de colores y palabras. Madrid: TEA Ediciones, S.A.
Grace, J., & Malloy, P. F. (2001). Frontal Systems Behavior Scale: Professional manual. Lutz, FL: Psychological Assessment Resources, Inc.
Grob, C. S., McKenna, D. J., Callaway, J. C., Brito, J. S., Neves, E. S., Oberlaender, G., et al. (1996). Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil. Journal of Nervous and Mental Disease, 184(2), 86–94.
Halpern, J. H., Sherwood, A. R., Passie, T., Blackwell, K. C., & Ruttenber, K. J. (2008). Evidence of health and safety in American members of a religion who use a hallucinogenic sacrament. Medical Science Monitor, 14(8), SR15–22.
Harris, R., & Gurel, L. (2012). A study of ayahuasca use in North America. Journal of Psychoactive Drugs, 44(3), 209–215.
James, W. (1902/1992). The varieties of religious experience: A study on human nature. London: Longmans, Green, & Co. Retrieved June 30, 2012 from: http://imagomundi.com.br/espiritualidade/james_varieties.pdf.
Labate, B. C., Rose, I. S., & dos Santos, R. G. (2008a). Ayahuasca religions: A comprehensive bibliography and critical essays. Santa Cruz, CA: MAPS.
Labate, B. C., Camurça, D. M., Brissac, S., & Ott, J. (2011). Hoasca ethnomedicine: Traditional use of “Nove Vegetais” (“Nine Herbs”) by the União do Vegetal. In B. C. Labate & H. Jungaberle (Eds.), The internationalization of ayahuasca (pp. 49–70). Zürich: LIT Verlag.
Labate, B. C., dos Santos, R. G., Strassman, R., Anderson, B., & Mizumoto, S. Effect of Santo Daime Membership on Substance Dependence. In this volume.
Labigalini, E. (1998). O uso de ayahuasca em um contexto religioso por ex-dependientes de alcohol: Um estudo qualitativo. Master’s thesis, Universidade Federal de São Paulo, Escuela Paulista de Medicina, São Paulo, Brazil. Retrieved June 30, 2012 from http://www.psiquiatriainfantil.com.br/artigo.asp?codigo=141. Accessed 2012 June 30.
Lamas, X., Farré, M., Llorente, M., & Camí, J. (1994). Spanish version of the 49-item short form of the Addiction Research Center Inventory (ARCI). Drug and Alcohol Dependence, 35(3), 203–209.
Lima, F., Naves, M., Migueli, J. C., Motta, J. M. C., & Brito, G. S. (2002). Sistema de monitoramento psiquiátrico em usuários do chá hoasca. Revista Brasileria de Psiquiatria, 24 (Suppl 2). Retrieved June 30, 2012 from: http://dx.doi.org/10.1590/S1516-44462002000600014.
Mabit, J. (2002). Blending traditions: Using indigenous medicinal knowledge to treat drug addiction. MAPS Bulletin, 7(2), 25–32. Retrieved June 30, 2012 from: http://maps.org/news-letters/v12n2/12225mab.pdf.
MacRae, E. (1992). Guided by the moon: Shamanism and the ritual use of ayahuasca in the Santo Daime religion in Brazil. São Paulo: Editora Brasiliense. Ebook retrieved June 30, 2012 from: http://www.neip.info/downloads/edward/acks.htm.
Ott, J. (1994). Ayahuasca analogues: Pangean entheogens. Kennewick, WA: Natural Products Co.
Plotkin, M. J. (1994). Tales of a shaman’s apprentice: An ethnobotanist searches for new medicines in the Amazon rain forest. New York, NY: Penguin Books.
Pedrero-Pérez, E. J., & Rojo Mota, G. (2008). Diferencias de personalidad entre adictos a sustancias y población general: Estudio con el TCI-R de casos clínicos con controles emparejados. Adicciones, 20(3), 251–262.
Riba, J., Rodríguez-Fornells, A., Strassman, R. J., & Barbanoj, M. J. (2001a). Psychometric assessment of the Hallucinogen Rating Scale. Drug and Alcohol Dependence, 62(3), 215–223.
Riba, J., Rodríguez-Fornells, A., Urbano, G., Morte, A., Antonijoan, R., Montero, M. et al. (2001b). Subjective effects and tolerability of the South American psychoactive beverage ayahuasca in healthy volunteers. Psychopharmacology (Berl), 154, 85–95.
Riba, J., Anderer, P., Morte, A., Urbano, G., Jane, F., Saletu, B., et al. (2002). Topographic pharmaco-EEG mapping of the effects of the South American psychoactive beverage ayahuasca in healthy volunteers. British Journal of Clinical Pharmacology, 53, 613–628.
Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003). Human pharmacology of ayahuasca: subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics, 306(1), 73–83.
Riba, J., Romero, S., Grasa, E., Mena, E., Carrió, J., & Barbanoj, M. J. (2006). Increased frontal and paralimbic activation following ayahuasca, the Pan-Amazonian inebriant. Psychopharmacology (Berl), 186(1), 93–98.
Ricciardi, G. S. (2008). O Uso da Ayahuasca e a experiência de “transformação” de ex-usuários de drogas no contexto religioso da União do Vegetal. 26ª Reunião Brasileira de Antropologia, Porto Seguro, Brasilia, June 1–4, 2008. Retrieved June 30, 2012 from http://www.neip.info/html/objects/_downloadblob.php?cod_blob=709.
Santos, R. G., & Strassman, R. J. (2008). Ayahuasca and psychosis. British Journal of Psychiatry (Online), 3 December. Retrieved June 30, 2012 from http://bjp.rcpsych.org/content/190/1/81.2/reply#bjrcpsych_el_22556.
Santos, R. G., Landeira-Fernandez, J., Strassman, R. J., Motta, V., & Cruz, A. P. (2007). Effects of ayahuasca on psychometric measures of anxiety, panic-like, and hopelessness in Santo Daime members. Journal of Ethnopharmacology, 112(3), 507–513.
Schultes, R. E., & Hofmann, A. (1979). Plants of the gods: Origins of hallucinogenic use. New York, NY: McGraw-Hill.
Villaescusa M. (2008). Proyecto IDEAA: Terapia integrativa de sustancias visionarias y disciplinas psicoespirituales en el tratamiento de toxicomanías. NEIP 2008. Retrieved June 30, 2012 from: http://www.neip.info/html/objects/_downloadblob.php?cod_blob=714.
Verdejo-García, A., Lawrence, A. J., & Clark, L. (2008). Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies. Neuroscience and Biobehavioral Reviews, 32(4), 777–810.
Wechsler, D. (1997). Wechsler Adult Intelligence Scale (3rd ed.). San Antonio, TX: The Psychological Corporation.
Winkelman, M. (2005). Drug tourism or spiritual healing? Ayahuasca seekers in Amazonia. Journal of Psychoactive Drugs, 37(2), 209–218.
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Bouso, J.C., Riba, J. (2014). Ayahuasca and the Treatment of Drug Addiction. In: Labate, B.C., Cavnar, C. (eds) The Therapeutic Use of Ayahuasca. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40426-9_6
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