Synonyms
Experimental medicine; Translational medicine; Translational science
Definition
Translational research aims to bring basic preclinical knowledge (from the bench) to clinical practice (to the bedside) by characterizing fundamental mechanisms that play a role in the disease in the laboratory, finding ways to measure this in the human disease state, and developing beneficial healthcare outcomes. It is an iterative process: not only should preclinical findings result in clinical applications, but clinical insights will inform and direct preclinical research. For psychopharmacology, translational research wants to enhance the confidence in a central mechanism that could be of relevance for the treatment of psychiatric or neurological patients by enhancing the predictive value of disease-relevant, preclinical models for the clinic, by refining these models based upon clinical findings (back translation), and by developing innovative human tests based on preclinical findings...
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Steckler, T., Talpos, J. (2015). Translational Research in Drug Discovery. In: Stolerman, I.P., Price, L.H. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36172-2_212
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DOI: https://doi.org/10.1007/978-3-642-36172-2_212
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Publisher Name: Springer, Berlin, Heidelberg
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