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Circadian Clocks and Metabolism

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Circadian Clocks

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 217))

Abstract

Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chapter reviews the emerging relationship between the molecular clock and metabolic systems and examines evidence that circadian disruption exerts deleterious consequences on human health.

Biliana Marcheva, Kathryn M. Ramsey, Clara B. Peek, Alison Affinati, Eleonore Maury have equally-contributed.

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Acknowledgements

C.B. Peek, A. Affinati and B. Marcheva are supported by NIH grants F32 DK092034-01, 1F30DK085936-01A1, and T32 DK007169, respectively. J. Bass is supported by NIH grants R01 HL097817-01, R01 DK090625-01A1, and P01 AG011412, the American Diabetes Association, the Chicago Biomedical Consortium Searle Funds, and the University of Chicago Diabetes Research and Training Center (grant P60 DK020595).

Disclosures J. Bass is a member of the scientific advisory board of ReSet Therapeutics Inc.

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  1. Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Lurie 7-107, Chicago, IL, 60611, USA

    Biliana Marcheva, Kathryn M. Ramsey, Clara B. Peek, Alison Affinati, Eleonore Maury & Joseph Bass

  2. Department of Neurobiology, Northwestern University, Evanston, IL, 60208, USA

    Biliana Marcheva, Kathryn M. Ramsey, Clara B. Peek, Alison Affinati, Eleonore Maury & Joseph Bass

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    Achim Kramer

  2. Ludwig-Maximilians-Universität München, Institute of Medical Psychology, Goethestrasse 31/ I, München, 80336, Germany

    Martha Merrow

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Marcheva, B., Ramsey, K.M., Peek, C.B., Affinati, A., Maury, E., Bass, J. (2013). Circadian Clocks and Metabolism. In: Kramer, A., Merrow, M. (eds) Circadian Clocks. Handbook of Experimental Pharmacology, vol 217. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25950-0_6

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