Definition
Processes by which drugs are discovered and designed with analytical techniques such as NMR.
Introduction
Drug discovery is an ongoing and challenging process that is fraught with failure, but the successes have had profound impacts on human health. Fundamentally, drug discovery is a multidisciplinary endeavor requiring, among others, bioinformatics and computational chemistry, cell biology, medicinal chemistry, enzymology, high-throughput screening (HTS), molecular biology, protein chemistry, genomics and other “omics” technologies, and structural biology. Drug discovery is also an iterative procedure comprising four stages: target identification and validation, lead discovery, lead optimization, and clinical trials (Betz et al. 2006). In general, the drug discovery process starts by identifying a protein target associated with drug resistance, the progression or pathology of a disease, or the...
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© 2013 European Biophysical Societies' Association (EBSA)
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Halouska, S., Powers, R. (2013). NMR in Drug Discovery – Introduction. In: Roberts, G.C.K. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16712-6_305
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DOI: https://doi.org/10.1007/978-3-642-16712-6_305
Publisher Name: Springer, Berlin, Heidelberg
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