Abstract
The current treatment of HCC is truly multidisciplinary. Notwithstanding, surgical management remains the gold standard which other therapies are compared to. Operative management is divided into transplantation and resection; the latter is further subdivided among open and laparoscopic approaches. Resection has become safer, remains superior to locoregional treatments, and can be a life-prolonging bridge to transplantation. The decision to pursue laparoscopic resection for HCC is driven by safety and a view toward the long-term management of both the malignancy and the underlying liver disease. For patients with a solitary HCC <5 cm in segments 2, 3, 4b, 5, and 6, no evidence of extrahepatic tumor burden, compensated liver disease, and the absence of significant portal hypertension, laparoscopy has an important role. Under these circumstances, resection can be performed with reduced mortality and morbidity and equivalent oncologic outcomes, disease-free survival, and overall survival when compared with similarly selected cirrhotic patients undergoing open resection. Blood loss and transfusion requirements are low, and laparoscopy itself does not expose the patient to complications and does not increase the risk of cancer recurrence or dissemination. Finally, because HCC recurrence remains high in the cirrhotic liver, treatment following surgical resection mandates routine surveillance and treatment by locoregional therapy, reresection, or transplantation as required—the latter two of which are facilitated by an initial laparoscopic resection.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- HCC:
-
Hepatocellular carcinoma
References
Huang J, Yan L, Cheng Z et al (2010) A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the milan criteria. Ann Surg 252:903–912
Cherqui D (2006) Surgery for hepatocellular carcinoma in patients with chronic liver disease. Br J Surg 10:1179–1181
Cherqui D, Laurent A, Mocellin N et al (2009) Liver resection for transplantable hepatocellular carcinoma: long-term survival and role of secondary liver transplantation. Ann Surg 250:738–746
Pompili M, Mirante VG, Rondinara G et al (2005) Percutaneous ablation procedures in cirrhotic patients with hepatocellular carcinoma submitted to liver transplantation: assessment of efficacy at explant analysis and of safety for tumor recurrence. Liver Transpl 11:1117–1126
Llovet JM, Bruix J (2008) Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol 48(Suppl 1):S20–S37
Mazzaferro V, Battiston C, Perrone S et al (2004) Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: a prospective study. Ann Surg 240(5):900–909
Tateishi R, Shiina S, Teratani T et al (2005) Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases. Cancer 103:1201–1209
Ng KK, Poon RT, Lo CM et al (2008) Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma. J Gastrointestinal Surg 12:183–191
Abdalla EK, Denys A, Hasegawa K et al (2008) Treatment of large and advanced hepatocellular carcinoma. Ann Surg Oncol 15(4):979–985
Capussotti L, Ferrero A, Viganò L et al (2009) Liver resection for HCC with cirrhosis: surgical perspectives out of EASL/AASLD guidelines. Eur J Surg Oncol 35(1):11–15
Torzilli G, Makuuchi M, Inoue K et al (1999) No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach. Arch Surg 134(9):984–992
Fan ST, Lo CM, Liu CL et al (1999) Hepatectomy for hepatocellular carcinoma: toward zero hospital deaths. Ann Surg 229(3):322–330
Abdalla EK, Hicks ME, Vauthey JN (2001) Portal vein embolization: rationale, technique and future prospects. Br J Surg 88(2):165–175
Bruix J, Sherman M (2011) AASLD practice guideline. management of hepatocellular carcinoma: an update. Hepatology 53(3):1020–1022
Llovet JM, Schwartz M, Fuster J et al (2006) Expanded criteria for hepatocellular carcinoma through down-staging prior to liver transplantation: not yet there. Semin Liver Dis 26:248–253
Sala M, Fuster J, Llovet JM et al (2004) High pathological risk of recurrence after surgical resection for hepatocellular carcinoma: An indication for salvage liver transplantation. Liver Transpl 10:1294–1300
Scatton O, Zalinski S, Terris B et al (2008) Hepatocellular carcinoma developed on compensated cirrhosis: resection as a selection tool for liver transplantation. Liver Transpl 14:779–788
Hoshida Y, Villanueva A, Kobayashi M et al (2008) Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 359:1995–2004
Ng KK, Lo CM, Liu CL et al (2008) Survival analysis of patients with transplantable recurrent hepatocellular carcinoma: implications for salvage liver transplant. Arch Surg 143(1):68–74
Margarit C, Escartin A, Castells L et al (2005) Resection for hepatocellular carcinoma is a good option in Child-Turcotte-Pugh class A patients with cirrhosis who are eligible for liver transplantation. Liver Transpl 10:1242–1251
Llovet JM, Fuster J, Bruix J (1999) Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology 30:1434–1440
Yao FY, Bass NM, Nikolai B et al (2002) Liver transplantation for hepatocellular carcinoma: analysis of survival according to the intention to-treat principle and drop-out from the waiting list. Liver Transpl 8:873–883
Belghiti J, Panis Y, Farges O et al (1991) Intrahepatic recurrence after resection of hepatocellular carcinoma complicating cirrhosis. Ann Surg 214:114–117
Poon RT, Fan ST, Lo CM et al (2001) Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years. Ann Surg 234:63–70
Grazi GL, Ercolani G, Pierangeli F et al (2001) Improved results of liver resection for hepatocellular carcinoma on cirrhosis give the procedure added value. Ann Surg 234:71–78
Del Gaudio M, Ercolani G, Ravaioli M et al (2008) Liver transplantation for recurrent hepatocellular carcinoma on cirrhosis after liver resection: University of Bologna experience. Am J Transplant 8:1177–1185
Cha CH, Ruo L, Fong Y et al (2003) Resection of hepatocellular carcinoma in patients otherwise eligible for transplantation. Ann Surg 238:315–323
Adam R, Azoulay D, Castaing D et al (2003) Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? Ann Surg 238:508–519
Belghiti J, Cortes A, Abdalla EK et al (2003) Resection prior to liver transplantation for hepatocellular carcinoma. Ann Surg 238:885–893
Dagher I, Proske JM, Carloni A et al (2007) Laparoscopic liver resection: results for 70 patients. Surg Endosc 21(4):619–624
Vibert E, Perniceni T, Levard H et al (2006) Laparoscopic liver resection. Br J Surg 93(1):67–72
Koffron AJ, Auffenberg G, Kung R et al (2007) Evaluation of 300 minimally invasive liver resections at a single institution: less is more. Ann Surg 246(3):385–392
Buell JF, Thomas MT, Rudich S et al (2008) Experience with more than 500 minimally invasive hepatic procedures. Ann Surg 248(3):475–486
Cho JY, Han HS, Yoon YS et al (2008) Experiences of laparoscopic liver resection including lesions in the posterosuperior segments of the liver. Surg Endosc 22(11):2344–2349
Cherqui D, Husson E, Hammoud R et al (2000) Laparoscopic liver resections: a feasibility study in 30 patients. Ann Surg 232(6):753–762
Torzilli G, Donadon M, Marconi M et al (2008) Hepatectomy for stage B and stage C hepatocellular carcinoma in the Barcelona Clinic Liver Cancer classification: results of a prospective analysis. Arch Surg 143(11):1082–1090
Capussotti L, Ferrero A, Viganò L et al (2006) Portal hypertension: contraindication to liver surgery? World J Surg 30(6):992–999
Cherqui D (2003) Laparoscopic liver resection. Br J Surg 90(6):644–646
Cho JY, Han HS, Yoon YS et al (2008) Feasibility of laparoscopic liver resection for tumors located in the posterosuperior segments of the liver, with a special reference to overcoming current limitations on tumor location. Surgery 144(1):32–38
Topal B, Fieuws S, Aerts R et al (2008) Laparoscopic versus open liver resection of hepatic neoplasms: comparative analysis of short-term results. Surg Endosc 22(10):2208–2213
Belli G, Fantini C, D’Agostino A et al (2007) Laparoscopic versus open liver resection for hepatocellular carcinoma in patients with histologically proven cirrhosis: short- and middle-term results. Surg Endosc 21(11):2004–2011
Chen HY, Juan CC, Ker CG (2008) Laparoscopic liver surgery for patients with hepatocellular carcinoma. Ann Surg Oncol 15(3):800–806
Bryant R, Laurent A, Tayar C et al (2009) Laparoscopic liver resection-understanding its role in current practice: the Henri Mondor Hospital experience. Ann Surg 250(1):103–111
Sasaki A, Nitta H, Otsuka K et al (2009) Ten-year experience of totally laparoscopic liver resection in a single institution. Br J Surg 96(3):274–279
Shimada M, Hashizume M, Maehara S et al (2001) Laparoscopic hepatectomy for hepatocellular carcinoma. Surg Endosc 15(6):541–544
Cai XJ, Yang J, Yu H et al. (2008) Clinical study of laparoscopic versus open hepatectomy for malignant liver tumors. Surg Endosc 22(11):2350–2356
Lesurtel M, Cherqui D, Laurent A et al (2003) Laparoscopic versus open left lateral hepatic lobectomy: a case-control study. J Am Coll Surg 196(2):236–242
Laurent A, Tayar C, Andreoletti M et al. (2009) Laparoscopic liver resection facilitates salvage liver transplantation for hepatocellular carcinoma. J Hepatobiliary Pancreat Surg 16(3):310–314
Belli G, Cioffi L, Fantini C et al. (2009) Laparoscopic redo surgery for recurrent hepatocellular carcinoma in cirrhotic patients: feasibility, safety, and results. Surg Endosc 23(8):1807–1811
Polignano FM, Quyn AJ, de Figueiredo RS et al (2008) Laparoscopic versus open liver segmentectomy: prospective, case-matched, intention-to-treat analysis of clinical outcomes and cost effectiveness. Surg Endosc 22(12):2564–2570
Nguyen KT, Gamblin TC, Geller DA (2009) World Review of Laparoscopic Liver Resection-2,804 Patients. Ann Surg 250(5):831–841
Vigano L, Tayar C, Laurent A et al. (2009) Laparoscopic liver resection: a systematic review. J Hepatobiliary Pancreat Surg 16(4):410–421
Troisi R, Montalti R, Smeets P et al (2008) The value of laparoscopic liver surgery for solid benign hepatic tumors. Surg Endosc 22(1):38–44
Vigano L, Laurent A, Tayar C et al (2009) The learning curve in laparoscopic liver resection: improved feasibility and reproducibility. Ann Surg 250(5):772–782
Santambrogio R, Aldrighetti L, Barabino M et al (2009) Laparoscopic liver resections for hepatocellular carcinoma. Is it a feasible option for patients with liver cirrhosis? Langenbecks Arch Surg 394(2):255–264
Kaneko H, Takagi S, Otsuka Y et al (2005) Laparoscopic liver resection of hepatocellular carcinoma. Am J Surg 189(2):190–194
Dagher I, Lainas P, Carloni A et al (2008) Laparoscopic liver resection for hepatocellular carcinoma. Surg Endosc 22(2):372–378
Lai EC, Tang CN, Yang GP et al (2009) Minimally invasive surgical treatment of hepatocellular carcinoma: long-term outcome. World J Surg 33:2150–2154
Chen HY, Juan CC, Ker CG (2008) Laparoscopic liver surgery for patients with hepatocellular carcinoma. Ann Surg Oncol 15(3):800–806
Huang MT, Wei PL, Wang W et al (2009) A series of laparoscopic liver resections with or without HALS in patients with hepatic tumors. J Gastrointest Surg 13(5):896–906
Inagaki H, Kurokawa T, Yokoyama T et al (2009) Results of laparoscopic liver resection: retrospective study of 68 patients. J Hepatobiliary Pancreat Surg 16(1):64–68
Lai EC, Tang CN, Ha JP (2009) Laparoscopic liver resection for hepatocellular carcinoma: ten-year experience in a single center. Arch Surg 144(2):143–147
Teramoto K, Kawamura T, Takamatsu S et al (2005) Laparoscopic and thoracoscopic approaches for the treatment of hepatocellular carcinoma. Am J Surg 189(4):474–478
Tranchart H, Di Giuro G, Lainas P et al (2010) Laparoscopic resection for hepatocellular carcinoma: a matched-pair comparative study. Surg Endosc 24(5):1170–1176
Descottes B, Glineur D, Lachachi F et al (2003) Laparoscopic liver resection of benign liver tumors. Surg Endosc 17(1):23–30
Kaneko H (2005) Laparoscopic hepatectomy: indications and outcomes. J Hepatobiliary Pancreat Surg 12(6):438–443
Cai XJ, Yu H, Liang X et al (2006) Laparoscopic hepatectomy by curettage and aspiration. Experiences of 62 cases. Surg Endosc 20(10):1531–1535
Mala T, Edwin B, Rosseland AR et al (2005) Laparoscopic liver resection: experience of 53 procedures at a single center. J Hepatobiliary Pancreat Surg 12(4):298–303
Yoon YS, Han HS, Cho JY et al (2010) Total laparoscopic liver resection for hepatocellular carcinoma located in all segments of the liver. Surg Endosc 24(7):1630–1637
Kaneko H, Tsuchiya M, Otsuka Y et al. (2009) Laparoscopic hepatectomy for hepatocellular carcinoma in cirrhotic patients. J Hepatobiliary Pancreat Surg 16(4):433–438
Laurent A, Cherqui D, Lesurtel M et al. (2003) Laparoscopic liver resection for subcapsular hepatocellular carcinoma complicating chronic liver disease. Arch Surg 138(7):763–769
Gigot JF, Glineur D, Santiago Azagra J et al. (2002) Laparoscopic liver resection for malignant liver tumors: preliminary results of a multicenter European study. Ann Surg 236(1):90–97
Johnstone PA, Rohde DC, Swartz SE et al (1996) Port site recurrences after laparoscopic and thoracoscopic procedures in malignancy. J Clin Oncol 14(6):1950–1956
Fong Y, Brennan MF, Turnbull A et al (1993) Gallbladder cancer discovered during laparoscopic surgery–potential for iatrogenic dissemination. Arch Surg 128:1054–1056
Sarpel U, Hefti MM, Wisnievsky JP et al (2009) Outcome for patients treated with laparoscopic versus open resection of hepatocellular carcinoma: case matched analysis. Ann Surg Oncol 16(6):1572–1577
Jaeck D, Bachellier P, Oussoultzoglou E et al. (2004) Surgical resection of hepatocellular carcinoma. Post-operative outcome and long-term results in Europe: an overview. Liver Transpl 10(2 Suppl 1):S58–63
Poon RT, Fan ST, Lo CM et al (2001) Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years. Ann Surg 234(1):63–70
Belli G, Limongelli P, Fantini C et al (2009) Laparoscopic and open treatment of hepatocellular carcinoma in patients with cirrhosis. Br J Surg 96(9):1041–1048
Cherqui D, Laurent A, Tayar C et al (2006) Laparoscopic liver resection for peripheral hepatocellular carcinoma in patients with chronic liver disease: Midterm results and perspectives. Ann Surg 243:499–506
Dagher I, Belli G, Fantini C et al (2010) Laparoscopic hepatectomy for hepatocellular carcinoma: a European experience. J Am Coll Surg 211(1):16–23
Belli G, Fantini C, D’Agostino A et al. (2007) Laparoscopic versus open liver resection for hepatocellular carcinoma in patients with histologically proven cirrhosis: short- and middle-term results. Surg Endosc. Nov;21(11):2004-11. Epub 2007 Aug 19
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kluger, M.D., Cherqui, D. (2013). Laparoscopic Resection of Hepatocellular Carcinoma. In: Vauthey, JN., Brouquet, A. (eds) Multidisciplinary Treatment of Hepatocellular Carcinoma. Recent Results in Cancer Research, vol 190. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16037-0_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-16037-0_8
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16036-3
Online ISBN: 978-3-642-16037-0
eBook Packages: MedicineMedicine (R0)