Abstract
In this study we investigate the use of multiscale Amplitude Modulation-Frequency Modulation (AM-FM) methods for analyzing brain white matter lesions that are associated with multiple sclerosis MRI lesions imaged at 0 and 6-12 months. We use the instantaneous amplitude (IA) and the instantaneous frequency (IF) to assess disease progression. The IA and the IF were calculated in transverse sections of T2- weighted magnetic resonance (MR) images acquired from 38 symptomatic untreated subjects between the first and the second examination scan. The findings suggest that the high-, medium-, and low- frequency scale instantaneous amplitude and frequency can be used to differentiate between normal tissue and lesions at 0 and 6-12 months. Moreover, support vector machine (SVM) models gave satisfactory results for differentiating lesions at 0 months using the medium scale IA and IF components for expanded disability status scale (EDSS) <=2 and EDSS >2. Further work is needed with more subjects in validating the proposed AM-FM analysis.
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© 2010 International Federation for Medical and Biological Engineering
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Loizou, C.P., Murray, V., Pattichis, M.S., Pantziaris, M., Seimenis, I., Pattichis, C.S. (2010). AM-FM Texture Image Analysis in Multiple Sclerosis Brain White Matter Lesions. In: Bamidis, P.D., Pallikarakis, N. (eds) XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010. IFMBE Proceedings, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13039-7_112
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DOI: https://doi.org/10.1007/978-3-642-13039-7_112
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-13038-0
Online ISBN: 978-3-642-13039-7
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