Skip to main content

Endoscopy with Biopsy for Esophagitis

  • Chapter
  • First Online:
  • 77 Accesses

Abstract

Endoscopy of the whole upper GI tract (esophagus, stomach, and duodenum) with multiple biopsies is the investigation of choice in the evaluation of infants and children with symptoms suggestive of esophagitis [1, 2]. From the technical and technique aspects, useful texts to refer to are available for pediatric-specific endoscopy nowadays [3, 4]. Endoscopy should be performed only by experienced and qualified pediatric endoscopists trained in endoscopy in infants and children, with appropriate back up from pediatric anesthesiologists, and most importantly pediatric GI histopathologists. Technology now allows us to perform esophagogastroduodenoscopy (EGD) in even the smallest infants using 5.5 mm diameter instruments [5, 6]. EGD and biopsy, however, are useful only if it will lead to alteration in diagnosis, treatment, or prognosis, and useful position papers for the individual and conjoint North American and European Pediatric Gastroenterology Societies have been published on reflux and esophagitis, including the place of endoscopy in management of these conditions [2, 7–11]. Short general anesthetic is preferable to IV sedation for the procedure for reasons of safety, ease, and success of a complete and comprehensive study [12], although, with an anesthesiologist present, short-acting agents such as propofol can be used.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Thomson M. The pediatric esophagus comes of age. J Pediatr Gastroenterol Nutr. 2002;34:S40–5.

    Article  PubMed  Google Scholar 

  2. Vandenplas Y. Reflux esophagitis in infants and children: a report from the Working Group on Gastro-oesophageal Reflux Disease of the European Society of Paediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1994;18:413–22.

    Article  CAS  PubMed  Google Scholar 

  3. Murphy M, Cadranel S, Winter H. Endoscopy in children. BC Decker Inc. 2006.

    Google Scholar 

  4. Gershwin G, Thomson M. Advanced endoscopy in pediatrics. Wiley-Blackwell 2010. ISBN 10: 1444336495 ISBN 13: 9781444336498.

    Google Scholar 

  5. Maki M, Ruuska T, Kuusela A, et al. High prevalence of asymptomatic esophageal and gastric lesions in preterm infants in intensive care. Crit Care Med. 1993;21:1863–7.

    Article  CAS  PubMed  Google Scholar 

  6. deBoissieu D, Dupont C, Barbet J, et al. Distinct features of upper gastrointestinal endoscopy in the newborn. J Pediatr Gastroenterol Nutr. 1994;18:334–8.

    Article  CAS  Google Scholar 

  7. Vandenplas Y, Rudolph CD, Di Lorenzo C, Hassall E, Liptak G, Mazur L, Sondheimer J, Staiano A, Thomson M, Veereman-Wauters G, Wenzl T. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of NASPGHAN and ESPGHAN. J Pediatr Gastroenterol Nutr. 2009;49(4):498–547.

    Article  PubMed  Google Scholar 

  8. St James-Roberts I, Conroy S, Wilsher K. Bases for maternal perceptions of infant crying and colic behaviour. Arch Dis Child. 1996;75:375–84.

    Article  Google Scholar 

  9. Berezin S, Medow M, Glassman M, Newman L. Esophageal chest pain in children with asthma. J Pediatr Gastroenterol Nutr. 1991;12:52–5.

    Article  CAS  PubMed  Google Scholar 

  10. Squires R, Coletti R. Indications for pediatric gastrointestinal endoscopy: a medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1996;23:107–10.

    Article  PubMed  Google Scholar 

  11. Hassall E, Israel D, Shepherd R, et al. Omeprazole for treatment of chronic erosive esophagitis in children: a multicenter study of efficacy, safety, tolerability and dose requirements. International Pediatric Omeprazole Study Group. J Pediatr. 2000;137(6):800–7.

    Article  CAS  PubMed  Google Scholar 

  12. Biller J, Winter H, Grand R, Allred E. Are endoscopic changes predictive of histologic esophagitis in children? J Pediatr. 1983;103:215–8.

    Article  CAS  PubMed  Google Scholar 

  13. Sampliner R, et al. Practice guidelines on the diagnosis, surveillance and therapy of Barrett’s esophagus. Am J Gastroenterol. 1998;93:1028–32.

    Article  CAS  PubMed  Google Scholar 

  14. Hassall E. Macroscopic versus microscopic diagnosis of reflux esophagitis: erosions or eosinophils? J Pediatr Gastroenterol Nutr. 1996;22:321–5.

    Article  CAS  PubMed  Google Scholar 

  15. Vandenplas Y. Reflux esophagitis: biopsy or not? J Pediatr Gastroenterol Nutr. 1996;22:326–7.

    Article  CAS  PubMed  Google Scholar 

  16. Savary M, Miller G. L’oesophage: manuel et atlas d’endoscopie. Soleure: Gasmann AB. 1977.

    Google Scholar 

  17. Sherman P, Hassall E, Fagundes-Neto U, Gold BD, Kato S, Koletzko S, Orenstein S, Rudolph C, Vakil N, Vandenplas Y. A global evidence-based consensus on the definition of gastroesophageal reflux disease in children. Am J Gastroenterol. 2009;104(5):1278–95.

    Article  PubMed  Google Scholar 

  18. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. The montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–20.

    Article  PubMed  Google Scholar 

  19. Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GN, Wallin L. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999;45:172–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Hetzel DJ, Dent J, Reed WD, Narielvala FM, Mackinnon M, McCarthy JH, Mitchell B, Beveridge BR, Laurence BH, Gibson GG, et al. Healing and relapse of severe peptic esophagitis after treatment with omeprazole. Gastroenterology. 1988;95:903–12.

    Article  CAS  PubMed  Google Scholar 

  21. Vieth M, Haringsma J, Delarive J, Wiesel PH, Tam W, Dent J, Tytgat GN, Stolte M, Lundell L. Red streaks in the oesophagus in patients with reflux disease: is there a histomorphological correlate? Scand J Gastroenterol. 2001;36:1123–7.

    Article  CAS  PubMed  Google Scholar 

  22. Bytzer P, Havelund T, Hansen JM. Interobserver variation in the endoscopic diagnosis of reflux esophagitis. Scand J Gastroenterol. 1993;28:119–25.

    Article  CAS  PubMed  Google Scholar 

  23. Pandolfino JE, Vakil NB, Kahrilas PJ. Comparison of inter- and intraobserver consistency for grading of esophagitis by expert and trainee endoscopists. Gastrointest Endosc. 2002;56:639–43.

    Article  PubMed  Google Scholar 

  24. Rath HC, Timmer A, Kunkel C, Endlicher E, Grossmann J, Hellerbrand C, Herfarth HH, Lock G, Sahrbacher U, Scholmerich J, Kullmann F, Messmann H. Comparison of interobserver agreement for different scoring systems for reflux esophagitis: impact of level of experience. Gastrointest Endosc. 2004;60:44–9.

    Article  PubMed  Google Scholar 

  25. Gunasekaran TS, Hassall EG. Efficacy and safety of omeprazole for severe gastroesophageal reflux in children. J Pediatr. 1993;123:148–54.

    Article  CAS  PubMed  Google Scholar 

  26. Boccia G, Manguso F, Miele E, Buonavolont’a R, Staiano A. Maintenance therapy for erosive esophagitis in children after healing by omeprazole: is it advisable? Am J Gastroenterol. 2007;192:1291–7.

    Article  Google Scholar 

  27. Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis PA, Hassall E, Straumann A, Rothenberg ME. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133:1342–63.

    Article  CAS  PubMed  Google Scholar 

  28. Dahms BB. Reflux esophagitis: sequelae and differential diagnosis in infants and children including eosinophilic esophagitis. Pediatr Dev Pathol. 2004;7:5–16.

    Article  PubMed  Google Scholar 

  29. Dent J. Microscopic esophageal mucosal injury in nonerosive reflux disease. Clin Gastroenterol Hepatol. 2007;5:4–16.

    Article  PubMed  Google Scholar 

  30. Hunt R, et al. Optimizing acid suppression for treatment of acid-related diseases. Dig Dis Sci. 1995;40:24S–49.

    Article  CAS  PubMed  Google Scholar 

  31. Gupta S, Fitzgerald J, Chong S, et al. Vertical lines in distal esophageal mucosa (VLEM): a true endoscopic manifestation of esophagitis in children? Gastrointest Endosc. 1997;45:485–9.

    Article  CAS  PubMed  Google Scholar 

  32. Isaac D, Parham D, Patrick C. The role of esophagoscopy in diagnosis and management of esophagitis in children with cancer. Med Pediatr Oncol. 1997;28:299–303.

    Article  CAS  PubMed  Google Scholar 

  33. Orenstein SR, Shalaby TM, Kelsey SF, Frankel E. Natural history of infant reflux esophagitis: symptoms and morphometric histology during one year without pharmacotherapy. Am J Gastroenterol. 2006;101:628–40.

    Article  PubMed  Google Scholar 

  34. Hill DJ, Heine RG, Cameron DJ, Catto-Smith AG, Chow CW, Francis DE, Hosking CS. Role of food protein intolerance in infants with persistent distress attributed to reflux esophagitis. J Pediatr. 2000;136:641–7.

    Article  CAS  PubMed  Google Scholar 

  35. Gillett P, Hassall E. Pediatric gastrointestinal mucosal biopsy. Special considerations in children. Gastrointest Endosc Clin N Am. 2000;10:669–712, vi–vii.

    CAS  PubMed  Google Scholar 

  36. Hassall E. Esophageal metaplasia: definition and prevalence in childhood. Gastrointest Endosc. 2006;64:676–7.

    Article  PubMed  Google Scholar 

  37. Boyce HW. Endoscopic definitions of esophagogastric junction regional anatomy. Gastrointest Endosc. 2000;51:586–92.

    Article  CAS  PubMed  Google Scholar 

  38. McClave SA, Boyce Jr HW, Gottfried MR. Early diagnosis of columnar-lined esophagus: a new endoscopic diagnostic criterion. Gastrointest Endosc. 1987;33:413–6.

    Article  CAS  PubMed  Google Scholar 

  39. Ofman JJ, Shaheen NJ, Desai AA, Moody B, Bozymski EM, Weinstein WM. The quality of care in Barrett’s esophagus: endoscopist and pathologist practices. Am J Gastroenterol. 2001;96:876–81.

    Article  CAS  PubMed  Google Scholar 

  40. Gordon C, Kang JY, Neild PJ, Maxwell JD. The role of the hiatus hernia in gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2004;20:719–32.

    Article  CAS  PubMed  Google Scholar 

  41. Hassall E, Kerr W, El-Serag HB. Characteristics of children receiving proton pump inhibitors continuously for up to 11 years duration. J Pediatr. 2007;150:262–7.

    Article  CAS  PubMed  Google Scholar 

  42. Weinstein WM, Ippoliti AF. The diagnosis of Barrett’s esophagus: goblets, goblets, goblets. Gastrointest Endosc. 1996;44:91–5.

    Article  CAS  PubMed  Google Scholar 

  43. Fink S, Barwick K, Winchenbach C, et al. Reassessment of esophageal histology in normal subjects: a comparison of suction and endoscopic techniques. J Clin Gastroenterol. 1983;3:177–83.

    Article  Google Scholar 

  44. Vandenplas Y, Salvatore S, Devreker T, Hauser B. Gastro-oesophageal reflux disease: oesophageal impedance versus pH monitoring. Acta Paediatr. 2007;96:956–62.

    Article  PubMed  Google Scholar 

  45. Cucchiara S, et al. Intraepithelial cells with irregular nuclear contours as a marker of esophagitis in children with gastroesophageal reflux disease. Dig Dis Sci. 1995;40:2305–11.

    Article  CAS  PubMed  Google Scholar 

  46. van Malenstein H, Farre R, Sifrim D. Esophageal dilated intercellular spaces (DIS) and nonerosive reflux disease. Am J Gastroenterol. 2008;103:1021–8.

    Article  PubMed  Google Scholar 

  47. Pope C. Is it necessary to perform a biopsy in erosive esophagitis? In: Giuli RTG, DeMeester TR, Galmiche J-P, editors. The esophageal mucosa. Amsterdam: Elsevier Press; 1994. p. 303–8.

    Google Scholar 

  48. Salvatore S, Hauser B, Vandemaele K, Novario R, Vandenplas Y. Gastroesophageal reflux disease in infants: how much is predictable with questionnaires, pH-metry, endoscopy and histology? J Pediatr Gastroenterol Nutr. 2005;40:210–5.

    Article  PubMed  Google Scholar 

  49. Steiner SJ, Gupta SK, Croffie JM, Fitzgerald JF. Correlation between number of eosinophils and reflux index on same day esophageal biopsy and 24 hour esophageal pH monitoring. Am J Gastroenterol. 2004;99:801–5.

    Article  PubMed  Google Scholar 

  50. Behar J, Sheahan D. Histologic abnormalities in reflux esophagitis. Arch Pathol. 1975;99:387–91.

    CAS  PubMed  Google Scholar 

  51. Ismail-Beigi F, Horton PF, Pope 2nd CE. Histological consequences of gastroesophageal reflux in man. Gastroenterology. 1970;58:163–74.

    CAS  PubMed  Google Scholar 

  52. Weinstein WM, Bogoch ER, Bowes KL. The normal human esophageal mucosa: a histological reappraisal. Gastroenterology. 1975;68:40–4.

    CAS  PubMed  Google Scholar 

  53. Heine RG, Cameron DJ, Chow CW, Hill DJ, Catto-Smith AG. Esophagitis in distressed infants: poor diagnostic agreement between esophageal pH monitoring and histopathologic findings. J Pediatr. 2002;140:14–9.

    Article  PubMed  Google Scholar 

  54. Ravelli AM, Villanacci V, Ruzzenenti N, Grigolato P, Tobanelli P, Klersy C, Rindi G. Dilated intercellular spaces: a major morphological feature of esophagitis. J Pediatr Gastroenterol Nutr. 2006;42:510–5.

    Article  PubMed  Google Scholar 

  55. Spechler SJ, Genta RM, Souza RF. Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Am J Gastroenterol. 2007;102:1301–6.

    Article  CAS  PubMed  Google Scholar 

  56. Borowitz S. Ulcerative esophagitis. A rare source of upper gastrointestinal bleeding in a neonate. Use of fiberoptic endoscopy for diagnosis. Clin Pediatr. 1989;28:89–91.

    Article  CAS  Google Scholar 

  57. Winter HS, et al. Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis. Gastroenterology. 1983;83:818–23.

    Google Scholar 

  58. Liacouras CA, et al. Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr. 1998;26:380–5.

    Article  CAS  PubMed  Google Scholar 

  59. Furuta GT. Eosinophils in the esophagus: acid is not the only cause. J Pediatr Gastroenterol Nutr. 1998;26:468–71.

    Article  CAS  PubMed  Google Scholar 

  60. Kelly KJ, et al. Eosinophilic esophagitis attributed to gastroesophageal reflux: Improvement with an amino acid-based formula. Gastroenterology. 1995;109:1503–12.

    Article  CAS  PubMed  Google Scholar 

  61. Iacono G, et al. Gastroesophageal reflux and cow’s milk allergy in infants: a prospective study. J Allergy Clin Immunol. 1996;97:822–7.

    Article  CAS  PubMed  Google Scholar 

  62. Mangano M, et al. Nature and significance of cells with irregular nuclear contours (CINC) in esophageal mucosa. Lab Invest. 1991;64:38A.

    Google Scholar 

  63. Wang HH, Mangano MM, Antonioli DA. Evaluation of T-lymphocytes in esophageal mucosal biopsies. Mod Pathol. 1994;7:55–8.

    CAS  PubMed  Google Scholar 

  64. Justinich C, et al. Activated eosinophils in esophagitis in children: a transmission electron microscopic study. J Pediatr Gastroenterol Nutr. 1997;25:194–8.

    Article  CAS  PubMed  Google Scholar 

  65. Shub M. Esophagitis: a frequent consequence of gastroesophageal reflux in infancy. J Pediatr. 1985;107:881–4.

    Article  CAS  PubMed  Google Scholar 

  66. Butt A, Murch S, Ng C-L, et al. Upregulated eotaxin expression and T-cell infiltration in the basal and papillary epithelium in cow’s milk associated reflux oesophagitis. Arch Dis Child. 2002;86:0–6.

    Google Scholar 

  67. Cavataio F, et al. Clinical and pH-metric characteristics of gastro-oesophageal reflux secondary to cows’ milk protein allergy. Arch Dis Child. 1996;75:51–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Geisenger K. Endoscopic biopsies and cytological brushings of the esophagus are diagnostically complementary. Am J Clin Pathol. 1995;103:295–9.

    Article  Google Scholar 

  69. Garcia-Zepeda EA, et al. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med. 1996;2:449–56.

    Article  CAS  PubMed  Google Scholar 

  70. Hitchcock R, Pemble M, Bishop A, et al. Quantitative study of the development and maturation of human oesophageal innervation. J Anat. 1992;180:175–83.

    PubMed  PubMed Central  Google Scholar 

  71. Preiksaitis H, Tremblay L, Diamant N. Nitric oxide mediates inhibitory nerve effects in human esophagus and lower esophageal sphincter. Dig Dis Sci. 1994;39:770–5.

    Article  CAS  PubMed  Google Scholar 

  72. Torrente F, Fitzhenry R, Heuschkel R, et al. Cow’s milk induces T cell proliferation and mucosal mast cell degranulation with neural tropism in an in vitro organ culture model. J Pediatr Gastroenterol Nutr. 2003;36:527.

    Google Scholar 

  73. Zicari A, et al. Increased levels of prostaglandins and nitric oxide in esophageal mucosa of children with reflux esophagitis. J Pediatr Gastroenterol Nutr. 1997;26:194–9.

    Article  Google Scholar 

  74. Gupta S, Fitzgerald J, Chong S, et al. Expression of inducible nitric oxide synthase (iNOS) mRNA in inflamed esophageal and colonic mucosa in a pediatric population. Am J Gastroenterol. 1998;93:795–8.

    Article  CAS  PubMed  Google Scholar 

  75. Fox VL, Nurko S, Teitelbaum JE, et al. High-resolution EUS in children with eosinophilic “allergic” esophagitis. Gastrointest Endosc. 2003;57:30–6.

    Article  PubMed  Google Scholar 

  76. Venkatesh K, Cohen M, Shaw C, Tiffin N, Delaney P, Thomas S, Taylor C, Abutaleb A, Thomson M. Feasibility of confocal endomicroscopy in the diagnosis of paediatric gastrointestinal disorders. World J Gastroenterol. 2009;15(18):2214–9.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Venkatesh K, Cohen C, Abou-Taleb A, Thomas S, Taylor C, Thomson M. A new method in the diagnosis of reflux esophagitis: confocal endomicroscopy. Gastrointest Endosc. 2012;75(4):864–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mike Thomson .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Thomson, M. (2017). Endoscopy with Biopsy for Esophagitis. In: Till, H., Thomson, M., Foker, J., Holcomb III, G., Khan, K. (eds) Esophageal and Gastric Disorders in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11202-7_79

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-11202-7_79

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11201-0

  • Online ISBN: 978-3-642-11202-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics