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Esophageal and Gastric Disorders in Infancy and Childhood pp 739–747Cite as

Eosinophilic Esophagitis (Europe)

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Abstract

Eosinophilic esophagitis (EE) is a chronic inflammatory condition of the esophagus in which eosinophils densely infiltrate the mucosa causing local effects including fibrosis of the lamina propria. Its mechanism is poorly known, but it involves an allergic background with increased expression of the chemoattractant eotaxin-3 and of IL-5, IL-3, and IL-13. EE causes abdominal pain, vomiting, heartburn, dysphagia, and food bolus impaction. Esophagoscopy shows trachealization, longitudinal furrows, and white exudates. Biopsy demonstrates ≥15 eosinophils per hpf. There is manometric and impedance evidence of dysmotility. Exclusion of food allergens, elemental diets, systemic and topic corticosteroids, and leukotriene inhibitors alleviates the symptoms, but recurrence is frequent. EE does not involve long-term risks of either Barrett’s esophagus or adenocarcinoma.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Hospital Universitario “La Paz”, Paseo de la Castellana, 261, Madrid, 28046, Spain

    Juan A. Tovar MD, PhD & Ana Lourdes Luis MD

  2. Department of Pediatric Surgery, Hospital Universitario Niño Jesús, Avda. Menendez Pelayo, 65, Madrid, 28009, Spain

    Cristina Riñón MD

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  1. Juan A. Tovar MD, PhD
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  2. Ana Lourdes Luis MD
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  3. Cristina Riñón MD
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Correspondence to Juan A. Tovar MD, PhD .

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Editors and Affiliations

  1. Medical University of Graz, Graz, Austria

    Holger Till

  2. Sheffield Children’s Hospital, Paediatric Gastroenterology Centre, Sheffield, United Kingdom

    Mike Thomson

  3. Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA

    John E. Foker

  4. Department Surgery, University of Missouri, Kansas City Children’s Mercy Hospital, Kansas City, Missouri, USA

    George W. Holcomb III

  5. University of Arizona, Tucson, Arizona, USA

    Khalid M. Khan

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Tovar, J.A., Luis, A.L., Riñón, C. (2017). Eosinophilic Esophagitis (Europe). In: Till, H., Thomson, M., Foker, J., Holcomb III, G., Khan, K. (eds) Esophageal and Gastric Disorders in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11202-7_62

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