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Duodeno-Gastric Reflux and Duodeno-Gastro-Oesophageal Reflux

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Abstract

A reflux of duodenal juice, containing bile and pancreatic secretions into the stomach, is called duodeno-gastric reflux (DGR). When these contents are mixed with contents of the stomach and reflux in the oesophagus, we are speaking of duodeno-gastro-oesophageal reflux (DGER). Several methods have been used for detection of DGR and DGER. The components of duodenal juice such as conjugated and unconjugated bile acids, trypsin and lysolecithin can injure mucosa and play an important role in the development of inflammation and in oncogenesis of the stomach and the oesophagus. Excessive DGR and DGER have been suggested to be involved in the pathogenesis of several foregut diseases such as chemical gastritis, functional dyspepsia, reflux oesophagitis, Barrett’s oesophagus and gastric and oesophageal carcinoma. Medical therapy is directed towards acid secretion inhibition, motility improvement and binding or neutralising bile acids. Different surgical procedures can be used in selected patients.

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Authors and Affiliations

  1. Department of Gastroenterology, Hepatology and Nutrition, University Medical Centre Ljubljana, Children’s Hospital, Bohoričeva 20, 1000, Ljubljana, Slovenia

    Rok Orel MD, PhD

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  1. Rok Orel MD, PhD
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Correspondence to Rok Orel MD, PhD .

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Editors and Affiliations

  1. Medical University of Graz, Graz, Austria

    Holger Till

  2. Sheffield Children’s Hospital, Paediatric Gastroenterology Centre, Sheffield, United Kingdom

    Mike Thomson

  3. Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA

    John E. Foker

  4. Department Surgery, University of Missouri, Kansas City Children’s Mercy Hospital, Kansas City, Missouri, USA

    George W. Holcomb III

  5. University of Arizona, Tucson, Arizona, USA

    Khalid M. Khan

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Orel, R. (2017). Duodeno-Gastric Reflux and Duodeno-Gastro-Oesophageal Reflux. In: Till, H., Thomson, M., Foker, J., Holcomb III, G., Khan, K. (eds) Esophageal and Gastric Disorders in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11202-7_128

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