Abstract
Hantaviruses, members of the Bunyaviridae family, are enveloped negative-stranded RNA viruses with tripartite genomes – S, M and L. The S genome codes for a nucleocapsid (N) protein, which is quite conserved among different species of the hantavirus genus and possess a recognized immunogenicity. In this work we analyzed the sequence of two regions in this protein (N94 − 101 and N180 − 188), which presents T cell epitopes for two species of hantaviruses – Sin Nombre and Puumala. Interestingly, the same region has no described epitopes for Hantaan virus, despite its similarity. A study using a bioinformatic approach for the construction of MHC:peptide complexes was performed to detect any variation on the cleft region that could explain such degrees of immunogenicity. Our results shown topological and charges differences among the constructed complexes.
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Rigo, M.M., Antunes, D.A., Vieira, G.F., Chies, J.A.B. (2009). MHC: Peptide Analysis: Implications on the Immunogenicity of Hantaviruses’ N protein. In: Guimarães, K.S., Panchenko, A., Przytycka, T.M. (eds) Advances in Bioinformatics and Computational Biology. BSB 2009. Lecture Notes in Computer Science(), vol 5676. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03223-3_17
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DOI: https://doi.org/10.1007/978-3-642-03223-3_17
Publisher Name: Springer, Berlin, Heidelberg
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