Skip to main content
SpringerLink
Log in
Book cover

Pathologie pp 571–609Cite as

Chronisch-entzündliche Erkrankungen des Kolorektums

  • Chapter
  • First Online:

  • 6371 Accesses

Part of the book series: Pathologie ((PATHOL))

Zusammenfassung

In diesem Kapitel werden die Hauptmanifestationen der chronisch-entzündlichen Darmerkrankungen (CED) – Colitis ulcerosa und M. Crohn – bezüglich Häufigkeit, Pathogenese, Morphologie, Differentialdiagnose und Therapieprinzipien erörtert. Die diagnostischen Kriterien zur Diagnose und Klassifikation der CED-assoziierten intraepithelialen Neoplasie und deren Abgrenzung gegenüber dem sporadischen Adenom aufgezeigt. Unter Berücksichtigung typischer extraintestinaler Manifestationen und Komplikationen ergeben sich für die jeweilige Manifestationsform der CED typische diagnostische Befundkonstellationen.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   359.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Literatur

  1. American Gastroenterological Association medical position statement (2003) Perianal Crohn's disease. Gastroenterology 125:1503–1507

    Article  Google Scholar 

  2. Adachi JD, Rostom A (1999) Metabolic bone disease in adults with inflammatory bowel disease. Inflamm Bowel Dis 5:200–211

    Article  CAS  PubMed  Google Scholar 

  3. Andant C, Godeberge B, Chaussade S et al (1999) Clinical course of symptomatic duodeno-jejunal Crohn's disease. Gastroenterol Clin Biol 23:1134–1138

    CAS  PubMed  Google Scholar 

  4. Andres PG, Friedman LS (1999) Epidemiology and the natural course of inflammatory bowel disease. Gastroenterol Clin North Am 28(vii):255–281

    Article  CAS  PubMed  Google Scholar 

  5. Aust DE, Willenbucher RF, Terdiman JP et al (2000) Chromosomal alterations in ulcerative colitis-related and sporadic colorectal cancers by comparative genomic hybridization. Hum Pathol 31:109–114

    Article  CAS  PubMed  Google Scholar 

  6. Bargiggia S, Maconi G, Elli M et al (2003) Sonographic prevalence of liver steatosis and biliary tract stones in patients with inflammatory bowel disease: study of 511 subjects at a single center. J Clin Gastroenterol 36:417–420

    Article  PubMed  Google Scholar 

  7. Barthet M, Hastier P, Bernard JP et al (1999) Chronic pancreatitis and inflammatory bowel disease: true or coincidental association? Am J Gastroenterol 94:2141–2148

    Article  CAS  PubMed  Google Scholar 

  8. Bauknecht KJ, Grosse G, Kleinert J et al (2000) Filiform polyposis of the colon in chronic inflammatory bowel disease (so-called giant inflammatory polyps). Z Gastroenterol 38:845–846

    Article  CAS  PubMed  Google Scholar 

  9. Benhattar J, Saraga E (1995) Molecular genetics of dysplasia in ulcerative colitis. Eur J Cancer 31 A:1171–1173

    Article  Google Scholar 

  10. Bernstein CN, Shanahan F, Weinstein WM (1994) Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis? Lancet 343:71–74

    Article  CAS  PubMed  Google Scholar 

  11. Bernstein CN (1999) Cancer surveillance in inflammatory bowel disease. Curr Gastroenterol Rep 1:496–504

    Article  CAS  PubMed  Google Scholar 

  12. Bernstein CN, Blanchard JF, Kliewer E et al (2001) Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer 91:854–862

    Article  CAS  PubMed  Google Scholar 

  13. Bernstein CN, Blanchard JF, Rawsthorne P et al (2001) The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study. Am J Gastroenterol 96:1116–1122

    Article  CAS  PubMed  Google Scholar 

  14. Bernstein D, Rogers A (1996) Malignancy in Crohn's disease. Am J Gastroenterol 91:434–440

    CAS  PubMed  Google Scholar 

  15. Biancone L, Michetti P, Travis S et al (2008) European evidence-based Consensus on the management of ulcerative colitis: Special situations. J Crohns Colitis 2:63–92

    Article  PubMed  Google Scholar 

  16. Bonen DK, Cho JH (2003) The genetics of inflammatory bowel disease. Gastroenterology 124:521–536

    Article  CAS  PubMed  Google Scholar 

  17. Borchard F (1999) Differential diagnosis of colitis. Verh Dtsch Ges Pathol 83:110–121

    CAS  PubMed  Google Scholar 

  18. Bosman FT, Carneiro F, Hruban RH et al (Hrsg) (2010) WHO Classification of tumours of the digestive system. IARC, Lyon

    Google Scholar 

  19. Braakhuis BJ, Tabor MP, Kummer JA et al (2003) A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 63:1727–1730

    CAS  PubMed  Google Scholar 

  20. Brentnall TA, Crispin DA, Bronner MP et al (1996) Microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res 56:1237–1240

    CAS  PubMed  Google Scholar 

  21. Bruwer M, Schmid KW, Senninger N et al (2002) Immunohistochemical expression of P53 and oncogenes in ulcerative colitis-associated colorectal carcinoma. World J Surg 26:390–396

    Article  PubMed  Google Scholar 

  22. Chapman RW (1999) Risk factors for biliary tract carcinogenesis. Ann Oncol 10(Suppl 4):308–311

    Article  PubMed  Google Scholar 

  23. Chassaing B, Darfeuille-Michaud A (2011) The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140:1720–1728

    Article  PubMed  Google Scholar 

  24. Chaubert P, Benhattar J, Saraga E et al (1994) K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. Am J Pathol 144:767–775

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Cho JH, Brant SR (2011) Recent insights into the genetics of inflammatory bowel disease. Gastroenterology 140:1704–1712

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Connell WR, Kamm MA, Dickson M et al (1994) Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease. Lancet 343:1249–1252

    Article  CAS  PubMed  Google Scholar 

  27. Corrao G, Tragnone A, Caprilli R et al (1998) Risk of inflammatory bowel disease attributable to smoking, oral contraception and breastfeeding in Italy: a nationwide case-control study. Cooperative Investigators of the Italian Group for the Study of the Colon and the Rectum (GISC). Int J Epidemiol 27:397–404

    Article  CAS  PubMed  Google Scholar 

  28. Cosnes J, Gower-Rousseau C, Seksik P et al (2011) Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology 140:1785–1794

    Article  PubMed  Google Scholar 

  29. Cottliar A, Fundia A, Boerr L et al (2000) High frequencies of telomeric associations, chromosome aberrations, and sister chromatid exchanges in ulcerative colitis. Am J Gastroenterol 95:2301–2307

    Article  CAS  PubMed  Google Scholar 

  30. Crohn BB, Ginsburg L, Oppenheimer GD (1932) Regional ileitis: A pathologic and clinical entity. J Am Med Assoc 99:1323–1329

    Article  Google Scholar 

  31. Delpre G, Kadish U, Gazit E et al (1980) HLA antigens in ulcerative colitis and Crohn's disease in Israel. Gastroenterology 78:1452–1457

    CAS  PubMed  Google Scholar 

  32. Dietz DW, Fazio VW, Laureti S et al (2002) Strictureplasty in diffuse Crohn's jejunoileitis: safe and durable. Dis Colon Rectum 45:764–770

    Article  PubMed  Google Scholar 

  33. Dignass A, Preiss JC, Aust DE et al (2011) Updated German guideline on diagnosis and treatment of ulcerative colitis, 2011. Z Gastroenterol 49:1276–1341

    Article  CAS  PubMed  Google Scholar 

  34. Dixon MF, Brown LJ, Gilmour HM et al (1988) Observer variation in the assessment of dysplasia in ulcerative colitis. Histopathology 13:385–397

    Article  CAS  PubMed  Google Scholar 

  35. Eaden J, Abrams K, McKay H et al (2001) Inter-observer variation between general and specialist gastrointestinal pathologists when grading dysplasia in ulcerative colitis. J Pathol 194:152–157

    Article  CAS  PubMed  Google Scholar 

  36. Eaden JA, Abrams KR, Mayberry JF (2001) The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 48:526–535

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Ekbom A, Helmick C, Zack M et al (1990) Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med 323:1228–1233

    Article  CAS  PubMed  Google Scholar 

  38. Ekbom A, Helmick C, Zack M et al (1991) The epidemiology of inflammatory bowel disease: a large, population-based study in Sweden. Gastroenterology 100:350–358

    Article  CAS  PubMed  Google Scholar 

  39. Elliott PR, Williams CB, Lennard-Jones JE et al (1982) Colonoscopic diagnosis of minimal change colitis in patients with a normal sigmoidoscopy and normal air-contrast barium enema. Lancet 1:650–651

    Article  CAS  PubMed  Google Scholar 

  40. Engelsgjerd M, Farraye FA, Odze RD (1999) Polypectomy may be adequate treatment for adenoma-like dysplastic lesions in chronic ulcerative colitis. Gastroenterology 117:1288–1294 (discussion 1488–1291)

    Article  CAS  PubMed  Google Scholar 

  41. Fabry TL, Sachar DB, Janowitz HD (1980) Acute myelogenous leukemia in patients with ulcerative colitis. J Clin Gastroenterol 2:225–227

    Article  CAS  PubMed  Google Scholar 

  42. Farmer RG, Easley KA, Rankin GB (1993) Clinical patterns, natural history, and progression of ulcerative colitis. A long-term follow-up of 1116 patients. Dig Dis Sci 38:1137–1146

    Article  CAS  PubMed  Google Scholar 

  43. Farrokhyar F, Swarbrick ET, Irvine EJ (2001) A critical review of epidemiological studies in inflammatory bowel disease. Scand J Gastroenterol 36:2–15

    Article  CAS  PubMed  Google Scholar 

  44. Fazio VW, Galandiuk S (1985) Strictureplasty in diffuse Crohn's jejunoileitis. Dis Colon Rectum 28:512–518

    Article  CAS  PubMed  Google Scholar 

  45. Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN et al (1999) Inflammatory bowel disease. In: Fenoglio-Preiser CM (Hrsg) Gastrointestinal pathology: An Atlas and Text. Lippincott-Raven, Philadelphia, S 631–716

    Google Scholar 

  46. Fogt F, Vortmeyer AO, Stolte M et al (1998) Loss of heterozygosity of the von Hippel Lindau gene locus in polypoid dysplasia but not flat dysplasia in ulcerative colitis or sporadic adenomas. Hum Pathol 29:961–964

    Article  CAS  PubMed  Google Scholar 

  47. Fogt F, Urbanski SJ, Sanders ME et al (2000) Distinction between dysplasia-associated lesion or mass (DALM) and adenoma in patients with ulcerative colitis. Hum Pathol 31:288–291

    Article  CAS  PubMed  Google Scholar 

  48. Forbes A, Cartwright A, Marchant S et al. (2003) Review article: Oral, modified-release mesalazine formulations–proprietary versus generic. Aliment Pharmacol Ther 17: 1207–1214

    Google Scholar 

  49. Fraquelli M, Losco A, Visentin S et al (2001) Gallstone disease and related risk factors in patients with Crohn disease: analysis of 330 consecutive cases. Arch Intern Med 161:2201–2204

    Article  CAS  PubMed  Google Scholar 

  50. Freeman HJ (2001) Colorectal cancer complicating Crohn's disease. Can J Gastroenterol 15:231–236

    Article  CAS  PubMed  Google Scholar 

  51. Geboes K, De Hertogh G (2003) Indeterminate colitis. Inflamm Bowel Dis 9:324–331

    Article  PubMed  Google Scholar 

  52. Gionchetti P, Amadini C, Rizzello F et al (2003) Diagnosis and treatment of pouchitis. Best Pract Res Clin Gastroenterol 17:75–87

    Article  PubMed  Google Scholar 

  53. Glasgow JF, Pinkerton CR, Sloan JM (1983) Serosal miliary Crohn's disease in association with probable coeliac disease. Arch Dis Child 58:149–151

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Goebell H, Forster S, Dirks E et al (1987) Crohn disease: clinical disease pattern in relation to site. A prospective analysis of 300 patients. Med Klin (Munich) 82:1–8

    CAS  Google Scholar 

  55. Goulston SJ, McGovern VJ (1969) Nature of strictures in chronic ulcerative colitis. Gut 10:952

    CAS  PubMed  Google Scholar 

  56. Greenson JK (2002) Dysplasia in inflammatory bowel disease. Semin Diagn Pathol 19:31–37

    PubMed  Google Scholar 

  57. Greenstein AJ, Aufses Jr AH (1985) Differences in pathogenesis, incidence and outcome of perforation in inflammatory bowel disease. Surg Gynecol Obstet 160:63–69

    CAS  PubMed  Google Scholar 

  58. Greenstein AJ, Mullin GE, Strauchen JA et al (1992) Lymphoma in inflammatory bowel disease. Cancer 69:1119–1123

    Article  CAS  PubMed  Google Scholar 

  59. Greenstein AJ, Sachar DB, Panday AK et al (1992) Amyloidosis and inflammatory bowel disease. A 50-year experience with 25 patients. Medicine (Baltimore) 71:261–270

    Article  CAS  Google Scholar 

  60. Greenstein AJ, Balasubramanian S, Harpaz N et al (1997) Carcinoid tumor and inflammatory bowel disease: a study of eleven cases and review of the literature. Am J Gastroenterol 92:682–685

    CAS  PubMed  Google Scholar 

  61. Greenstein AJ (2000) Cancer in inflammatory bowel disease. Mt Sinai J Med 67:227–240

    CAS  PubMed  Google Scholar 

  62. Guest GD, Fink RL (2000) Metastatic Crohn's disease: case report of an unusual variant and review of the literature. Dis Colon Rectum 43:1764–1766

    Article  CAS  PubMed  Google Scholar 

  63. Gumaste V, Sachar DB, Greenstein AJ (1992) Benign and malignant colorectal strictures in ulcerative colitis. Gut 33:938–941

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Hanauer SB, Present DH (2003) The state of the art in the management of inflammatory bowel disease. Rev Gastroenterol Disord 3:81–92

    PubMed  Google Scholar 

  65. Hanauer SB (2004) Medical therapy for ulcerative colitis 2004. Gastroenterology 126:1582–1592

    Article  PubMed  Google Scholar 

  66. Hegarty AM, Barrett AW, Scully C (2004) Pyostomatitis vegetans. Clin Exp Dermatol 29:1–7

    Article  CAS  PubMed  Google Scholar 

  67. Heinzlmann M, Lang SM, Neynaber S et al (2002) Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease. Eur J Gastroenterol Hepatol 14:1061–1066

    Article  CAS  PubMed  Google Scholar 

  68. Heise W, Kersten O, Kassner KM et al (1997) Fulminant primary manifestation of Crohn's colitis "Hot Crohn's disease". Z Gastroenterol 35:481–490

    CAS  PubMed  Google Scholar 

  69. Herrlinger K, Fellermann K, Stange EF (2002) Standard therapy of ulcerative colitis. Evidence- and consensus-based recommendations. Internist (Berl) 43:1367–1368 (1371–1365)

    Article  CAS  Google Scholar 

  70. Hibi T, Inoue N, Ogata H et al (2003) Introduction and overview: recent advances in the immunotherapy of inflammatory bowel disease. J Gastroenterol 38(Suppl 15):36–42

    CAS  PubMed  Google Scholar 

  71. Hodgson HJ, Potter BJ, Jewell DP (1977) Immune complexes in ulcerative colitis and Crohn's disease. Clin Exp Immunol 29:187–196

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Hodgson HJ, Wands JR, Isselbacher KJ (1978) Decreased suppressor cell activity in inflammatory bowel disease. Clin Exp Immunol 32:451–458

    CAS  PubMed  PubMed Central  Google Scholar 

  73. Hoffmann JC, Preiss JC, Autschbach F et al (2008) Clinical practice guideline on diagnosis and treatment of Crohn's disease. Z Gastroenterol 46:1094–1146

    Article  CAS  PubMed  Google Scholar 

  74. Hofseth LJ, Saito S, Hussain SP et al (2003) Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci USA 100:143–148

    Article  CAS  PubMed  Google Scholar 

  75. Hollander D (1993) Permeability in Crohn's disease: altered barrier functions in healthy relatives? Gastroenterology 104:1848–1851

    Article  CAS  PubMed  Google Scholar 

  76. Holzmann K, Klump B, Borchard F et al (1998) Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis. Int J Cancer 76:1–6

    Article  CAS  PubMed  Google Scholar 

  77. Holzmann K, Klump B, Weis-Klemm M et al (2000) Telomerase activity in long-standing ulcerative colitis. Anticancer Res 20:3951–3955

    CAS  PubMed  Google Scholar 

  78. Hugot JP, Zouali H, Lesage S et al (1999) Etiology of the inflammatory bowel diseases. Int J Colorectal Dis 14:2–9

    Article  CAS  PubMed  Google Scholar 

  79. Hussain SP, Amstad P, Raja K et al (2000) Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res 60:3333–3337

    CAS  PubMed  Google Scholar 

  80. Iizuka M, Saito H, Yukawa M et al (2001) No evidence of persistent mumps virus infection in inflammatory bowel disease. Gut 48:637–641

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Janowitz HD (2000) Inflammatory bowel disease after 1932. Mt Sinai J Med 67:190–197

    CAS  PubMed  Google Scholar 

  82. Jenkins D, Balsitis M, Gallivan S et al (1997) Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. J Clin Pathol 50:93–105

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Jenss H, Malchow H (1979) Recurrence in ulcerative colitis following colectomy? – Only what may be, can be (author's transl). Z Gastroenterol 17:745–748

    CAS  PubMed  Google Scholar 

  84. Jiang XL, Cui HF (2002) An analysis of 10218 ulcerative colitis cases in China. World J Gastroenterol 8:158–161

    Article  PubMed  PubMed Central  Google Scholar 

  85. Judge TA, Lewis JD, Lichtenstein GR (2002) Colonic dysplasia and cancer in inflammatory bowel disease. Gastrointest Endosc Clin N Am 12:495–523

    Article  PubMed  Google Scholar 

  86. Katschinski B, Fingerle D, Scherbaum B et al (1993) Oral contraceptive use and cigarette smoking in Crohn's disease. Dig Dis Sci 38:1596–1600

    Article  CAS  PubMed  Google Scholar 

  87. Kern SE, Redston M, Seymour AB et al (1994) Molecular genetic profiles of colitis-associated neoplasms. Gastroenterology 107:420–428

    Article  CAS  PubMed  Google Scholar 

  88. Klump B, Holzmann K, Kuhn A et al (1997) Distribution of cell populations with DNA aneuploidy and p53 protein expression in ulcerative colitis. Eur J Gastroenterol Hepatol 9:789–794

    Article  CAS  PubMed  Google Scholar 

  89. Knill-Jones RP, Morson B, Williams R (1970) Prestomal ileitis: clinical and pathological findings in five cases. Q J Med 39:287–297

    CAS  PubMed  Google Scholar 

  90. Konishi F, Wakasa H, Kino I et al (1995) Histological classification of the neoplastic changes arising in ulcerative colitis: a new proposal in Japan. J Gastroenterol 30(Suppl 8):20–24

    PubMed  Google Scholar 

  91. Kortbeek J, Kelly JK, Preshaw RM (1992) Carcinoid tumors and inflammatory bowel disease. J Surg Oncol 49:122–126

    Article  CAS  PubMed  Google Scholar 

  92. Kroesen AJ, Schreiber S, Buhr HJ (2002) Pouchitis – pathophysiology and therapy. Zentralbl Chir 127:921–932

    Article  CAS  PubMed  Google Scholar 

  93. Ky A, Sohn N, Weinstein MA et al (1998) Carcinoma arising in anorectal fistulas of Crohn's disease. Dis Colon Rectum 41:992–996

    Article  CAS  PubMed  Google Scholar 

  94. Kyle J (1992) Crohn's disease in the northeastern and northern Isles of Scotland: an epidemiological review. Gastroenterology 103:392–399

    Article  CAS  PubMed  Google Scholar 

  95. Langholz E, Munkholm P, Davidsen M et al (1992) Colorectal cancer risk and mortality in patients with ulcerative colitis. Gastroenterology 103:1444–1451

    Article  CAS  PubMed  Google Scholar 

  96. Lashner BA, Kane SV, Hanauer SB (1989) Lack of association between oral contraceptive use and Crohn's disease: a community-based matched case-control study. Gastroenterology 97:1442–1447

    Article  CAS  PubMed  Google Scholar 

  97. Laurent-Puig P, Blons H, Cugnenc PH (1999) Sequence of molecular genetic events in colorectal tumorigenesis. Eur J Cancer Prev 8(Suppl 1):S39–S47

    PubMed  Google Scholar 

  98. Lennard-Jones JE, Melville DM, Morson BC et al (1990) Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years. Gut 31:800–806

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Lewis JD, Bilker WB, Brensinger C et al (2001) Inflammatory bowel disease is not associated with an increased risk of lymphoma. Gastroenterology 121:1080–1087

    Article  CAS  PubMed  Google Scholar 

  100. Lewis JD (2011) The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease. Gastroenterology 140:1817–1826 (e1812)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Lichtenstein GR (2002) Reduction of colorectal cancer risk in patients with Crohn's disease. Rev Gastroenterol Disord 2(Suppl 2):S16–S24

    PubMed  Google Scholar 

  102. Lindberg JO, Stenling RB, Rutegard JN (1999) DNA aneuploidy as a marker of premalignancy in surveillance of patients with ulcerative colitis. Br J Surg 86:947–950

    Article  CAS  PubMed  Google Scholar 

  103. Lisby G, Andersen J, Engbaek K et al (1994) Mycobacterium paratuberculosis in intestinal tissue from patients with Crohn's disease demonstrated by a nested primer polymerase chain reaction. Scand J Gastroenterol 29:923–929

    Article  CAS  PubMed  Google Scholar 

  104. Loffeld RJ, Overtoom HA, Balk AT (1996) Diffuse jejunoileitis with vasculitic abnormalities in the mesenteric arteries: a rare manifestation of Crohn's disease. Neth J Med 48:85–88

    Article  CAS  PubMed  Google Scholar 

  105. Lotti TM, Comacchi C, Ghersetich I (1999) Cutaneous necrotizing vasculitis. Relation to systemic disease. Adv Exp Med Biol 455:115–125

    Article  CAS  PubMed  Google Scholar 

  106. Ludwig D, Stange EF (2000) Treatment of ulcerative colitis. Hepatogastroenterology 47:83–89

    CAS  PubMed  Google Scholar 

  107. Lumley JW, Stitz RW (1991) Crohn's disease and anal carcinoma: an association? A case report and review of the literature. Aust N Z J Surg 61:76–77

    Article  CAS  PubMed  Google Scholar 

  108. Lyda MH, Noffsinger A, Belli J et al (2000) Microsatellite instability and K-ras mutations in patients with ulcerative colitis. Hum Pathol 31:665–671

    Article  CAS  PubMed  Google Scholar 

  109. Matsuda K, Watanabe H, Ajioka Y et al (1996) Ulcerative colitis with overexpression of p53 preceding overt histological abnormalities of the epithelium. J Gastroenterol 31:860–867

    Article  CAS  PubMed  Google Scholar 

  110. Mekhjian HS, Switz DM, Melnyk CS et al (1979) Clinical features and natural history of Crohn's disease. Gastroenterology 77:898–906

    CAS  PubMed  Google Scholar 

  111. Mellemkjaer L, Olsen JH, Frisch M et al (1995) Cancer in patients with ulcerative colitis. Int J Cancer 60:330–333

    Article  CAS  PubMed  Google Scholar 

  112. Mellemkjaer L, Johansen C, Gridley G et al (2000) Crohn's disease and cancer risk (Denmark). Cancer Causes Control 11:145–150

    Article  CAS  PubMed  Google Scholar 

  113. Mendeloff AI (1980) The epidemiology of inflammatory bowel disease. Clin Gastroenterol 9:259–270

    CAS  PubMed  Google Scholar 

  114. Merrett MN (1997) Ileal pouches: adaptation and inflammation. Baillieres Clin Gastroenterol 11:175–193

    Article  CAS  PubMed  Google Scholar 

  115. Mignon M, Stettler C, Phillips SF (1995) Pouchitis – a poorly understood entity. Dis Colon Rectum 38:100–103

    Article  CAS  PubMed  Google Scholar 

  116. Morson BC (1980) Pathology of ulcerative colitis. In: Kirsner JB, Shorter RG (Hrsg) Inflammatory bowel disease. Lea and Febiger, Philadelphia, S 281

    Google Scholar 

  117. Mueller E, Vieth M, Stolte M et al (1999) The differentiation of true adenomas from colitis-associated dysplasia in ulcerative colitis: a comparative immunohistochemical study. Hum Pathol 30:898–905

    Article  CAS  PubMed  Google Scholar 

  118. Neurath MF, Finotto S, Glimcher LH (2002) The role of Th1/Th2 polarization in mucosal immunity. Nat Med 8:567–573

    Article  CAS  PubMed  Google Scholar 

  119. O'Sullivan JN, Bronner MP, Brentnall TA et al (2002) Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet 32:280–284

    Article  PubMed  CAS  Google Scholar 

  120. Oberhuber G, Hirsch M, Stolte M (1998) High incidence of upper gastrointestinal tract involvement in Crohn's disease. Virchows Arch 432:49–52

    Article  CAS  PubMed  Google Scholar 

  121. Odze R (2003) Diagnostic problems and advances in inflammatory bowel disease. Mod Pathol 16:347–358

    Article  PubMed  Google Scholar 

  122. Odze RD, Brown CA, Hartmann CJ et al (2000) Genetic alterations in chronic ulcerative colitis-associated adenoma- like DALMs are similar to non-colitic sporadic adenomas. Am J Surg Pathol 24:1209–1216

    Article  CAS  PubMed  Google Scholar 

  123. Odze RD, Goldblum J, Noffsinger A et al (2002) Interobserver variability in the diagnosis of ulcerative colitis-associated dysplasia by telepathology. Mod Pathol 15:379–386

    Article  PubMed  Google Scholar 

  124. Otto HF, Gebbers JO, Kugler S (1975) A case of „miliary“ Crohn's disease (author's transl). Dtsch Med Wochenschr 100:505–507

    Article  CAS  PubMed  Google Scholar 

  125. Oudkerk Pool M, Ellerbroek PM, Ridwan BU et al (1993) Serum antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease are mainly associated with ulcerative colitis. A correlation study between perinuclear antineutrophil cytoplasmic autoantibodies and clinical parameters, medical, and surgical treatment. Gut 34:46–50

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  126. Pardi DS, Loftus Jr EV, Tremaine WJ et al (1999) Acute major gastrointestinal hemorrhage in inflammatory bowel disease. Gastrointest Endosc 49:153–157

    Article  CAS  PubMed  Google Scholar 

  127. Peeters M, Cortot A, Vermeire S et al (2000) Familial and sporadic inflammatory bowel disease: different entities? Inflamm Bowel Dis 6:314–320

    CAS  PubMed  Google Scholar 

  128. Pena AS, Crusius JB (1998) Genetics of inflammatory bowel disease: implications for the future. World J Surg 22:390–393

    Article  CAS  PubMed  Google Scholar 

  129. Pereira SP, Bain IM, Kumar D et al (2003) Bile composition in inflammatory bowel disease: ileal disease and colectomy, but not colitis, induce lithogenic bile. Aliment Pharmacol Ther 17:923–933

    Article  CAS  PubMed  Google Scholar 

  130. Perrin D, Visset J, Gaillard F et al (1980) Colectomy and ileostomy for ulcerative colitis: prestomal ileitis. Med Chir Dig 9:507–510

    CAS  PubMed  Google Scholar 

  131. Platell C, Mackay J, Woods R (2001) A multivariate analysis of risk factors associated with recurrence following surgery for Crohn's disease. Colorectal Dis 3:100–106

    Article  CAS  PubMed  Google Scholar 

  132. Pohl C, Hombach A, Kruis W (2000) Chronic inflammatory bowel disease and cancer. Hepatogastroenterology 47:57–70

    CAS  PubMed  Google Scholar 

  133. Porschen R, Strohmeyer G (1991) Risk of dysplasia and carcinoma in ulcerative colitis. Dtsch Med Wochenschr 116:1682–1688

    Article  CAS  PubMed  Google Scholar 

  134. Porschen R, Molsberger G, Reis C et al (1992) DNA ploidy and dysplasia in ulcerative colitis – interim analysis of a prospective study. Z Gastroenterol 30:857–862

    CAS  PubMed  Google Scholar 

  135. Porschen R, Robin U, Schumacher A et al (1992) DNA aneuploidy in Crohn's disease and ulcerative colitis: results of a comparative flow cytometric study. Gut 33:663–667

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  136. Porschen R, Strohmeyer G (1992) Risk of colorectal cancer in ulcerative colitis – monitoring strategies and identification of risk patients. Z Gastroenterol 30:585–593

    CAS  PubMed  Google Scholar 

  137. Porschen R (2001) Guidelines of the DGVS. Prevention of carcinoma. German Society of Digestive and Metabolic Diseases. Z Gastroenterol 39:51–54

    Article  CAS  PubMed  Google Scholar 

  138. Raj V, Lichtenstein DR (1999) Hepatobiliary manifestations of inflammatory bowel disease. Gastroenterol Clin North Am 28:491–513

    Article  CAS  PubMed  Google Scholar 

  139. Rammert C, Kullak-Ublick GA (2003) Management of ulcerative colitis. Ther Umsch 60:145–150

    Article  PubMed  Google Scholar 

  140. Ribeiro MB, Greenstein AJ, Yamazaki Y et al (1991) Intra-abdominal abscess in regional enteritis. Ann Surg 213:32–36

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  141. Riddell RH, Goldman H, Ransohoff DF et al (1983) Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 14:931–968

    Article  CAS  PubMed  Google Scholar 

  142. Riddell RH (1995) Grading of dysplasia. Eur J Cancer 31 A:1169–1170

    Article  Google Scholar 

  143. Risques RA, Moreno V, Ribas M et al (2003) Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancer. Cancer Res 63:7206–7214

    CAS  PubMed  Google Scholar 

  144. Rubin DT, Hanauer SB (2000) Smoking and inflammatory bowel disease. Eur J Gastroenterol Hepatol 12:855–862

    Article  CAS  PubMed  Google Scholar 

  145. Scapa E, Marcus EL, Kaufman S et al (1993) Miliary Crohn's disease: early or different? J Clin Gastroenterol 16:222–226

    Article  CAS  PubMed  Google Scholar 

  146. Schafer K, Tiedjen KU, Bohm E et al (1992) Angioarchitecture of the ileum and colon in Crohn disease. Zentralbl Chir 117:417–422

    CAS  PubMed  Google Scholar 

  147. Schlemper RJ, Riddell RH, Kato Y et al (2000) The Vienna classification of gastrointestinal epithelial neoplasia. Gut 47:251–255

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  148. Schneider A, Stolte M (1993) Differential diagnosis of adenomas and dysplastic lesions in patients with ulcerative colitis. Z Gastroenterol 31:653–656

    CAS  PubMed  Google Scholar 

  149. Schneider W, Rosahl W (1986) Incidence of severe local complications in ulcerative colitis and Crohn disease. Z Gesamte Inn Med 41:533–536

    CAS  PubMed  Google Scholar 

  150. Schurmann G, Ochman S, Neurath MF (2000) Colonic carcinoma associated with ulcerative colitis. Risk factors, molecular pathogenesis and surveillance. Dtsch Med Wochenschr 125:1045–1050

    Article  CAS  PubMed  Google Scholar 

  151. Seibold F, Slametschka D, Gregor M et al (1994) Neutrophil autoantibodies: a genetic marker in primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 107:532–536

    Article  CAS  PubMed  Google Scholar 

  152. Seril DN, Liao J, Yang GY et al (2003) Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis 24:353–362

    Article  CAS  PubMed  Google Scholar 

  153. Shivananda S, Pena AS, Nap M et al (1987) Epidemiology of Crohn's disease in Regio Leiden, The Netherlands. A population study from 1979 to 1983. Gastroenterology 93:966–974

    Article  CAS  PubMed  Google Scholar 

  154. Sjodahl RI, Myrelid P, Soderholm JD (2003) Anal and rectal cancer in Crohn's disease. Colorectal Dis 5:490–495

    Article  CAS  PubMed  Google Scholar 

  155. Slater G, Greenstein A, Aufses Jr AH (1984) Anal carcinoma in patients with Crohn's disease. Ann Surg 199:348–350

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  156. Softley A, Clamp SE, Bouchier IA et al (1988) Perforation of the intestine in inflammatory bowel disease. An OMGE survey. Scand J Gastroenterol Suppl 144:24–26

    CAS  PubMed  Google Scholar 

  157. Sonnenberg A (1990) Occupational distribution of inflammatory bowel disease among German employees. Gut 31:1037–1040

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  158. Stainsby KJ, Lowes JR, Allan RN et al (1993) Antibodies to Mycobacterium paratuberculosis and nine species of environmental mycobacteria in Crohn's disease and control subjects. Gut 34:371–374

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  159. Stange EF (2001) Guidelines of the DGVS. Fulminant process. German Society of Digestive and Metabolic Diseases. Z Gastroenterol 39:39–42

    Article  CAS  PubMed  Google Scholar 

  160. Stange EF, Riemann J, von Herbay A et al (2001) Diagnosis and therapy of ulcerative colitis – results of an evidence-based consensus conference of the German Society of Digestive and Metabolic Diseases. Z Gastroenterol 39:19–20

    Article  CAS  PubMed  Google Scholar 

  161. Staros EB (2003) Molecular discoveries alter our view of inflammatory bowel disease. A review from scientific, clinical, and laboratory perspectives. Am J Clin Pathol 119:524–539

    Article  PubMed  Google Scholar 

  162. Steinhardt HJ, Loeschke K, Kasper H et al (1985) European Cooperative Crohn's Disease Study (ECCDS): clinical features and natural history. Digestion 31:97–108

    Article  CAS  PubMed  Google Scholar 

  163. Stocchi L, Pemberton JH (2001) Pouch and pouchitis. Gastroenterol Clin North Am 30:223–241

    Article  CAS  PubMed  Google Scholar 

  164. Stonnington CM, Phillips SF, Melton 3rd LJ et al (1987) Chronic ulcerative colitis: incidence and prevalence in a community. Gut 28:402–409

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  165. Storch I, Sachar D, Katz S (2003) Pulmonary manifestations of inflammatory bowel disease. Inflamm Bowel Dis 9:104–115

    Article  PubMed  Google Scholar 

  166. Tan WC, Allan RN (1993) Diffuse jejunoileitis of Crohn's disease. Gut 34:1374–1378

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  167. Tanaka M, Riddell RH, Saito H et al (1999) Morphologic criteria applicable to biopsy specimens for effective distinction of inflammatory bowel disease from other forms of colitis and of Crohn's disease from ulcerative colitis. Scand J Gastroenterol 34:55–67

    Article  CAS  PubMed  Google Scholar 

  168. Tannapfel A, Wittekind C (2001) Anatomy and pathology of intrahepatic and extrahepatic bile duct tumors. Pathologe 22:114–123

    Article  CAS  PubMed  Google Scholar 

  169. Taylor KB (1980) Ulcerative colitis and Crohns's disease of the colon: symptoms, signs, and laboratory aspects. In: Kirsner JB, Shorter RG (Hrsg) Inflammatory bowel disease. Lea and Febiger, Philadelphia, S 141

    Google Scholar 

  170. Thornton M, Solomon MJ (2002) Crohn's disease: in defense of a microvascular aetiology. Int J Colorectal Dis 17:287–297

    Article  PubMed  Google Scholar 

  171. Tomlinson I, Ilyas M, Johnson V et al (1998) A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. J Pathol 184:148–152

    Article  CAS  PubMed  Google Scholar 

  172. Ullman TA, Itzkowitz SH (2011) Intestinal inflammation and cancer. Gastroenterology 140:1807–1816

    Article  CAS  PubMed  Google Scholar 

  173. Umetani N, Sasaki S, Watanabe T et al (1999) Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability. Jpn J Cancer Res 90:1081–1087

    Article  CAS  PubMed  Google Scholar 

  174. Uthoff SM, Eichenberger MR, Lewis RK et al (2001) Identification of candidate genes in ulcerative colitis and Crohn's disease using cDNA array technology. Int J Oncol 19:803–810

    CAS  PubMed  Google Scholar 

  175. van Hogezand RA, Eichhorn RF, Choudry A et al (2002) Malignancies in inflammatory bowel disease: fact or fiction? Scand J Gastroenterol (Suppl):48–53

    Google Scholar 

  176. Vieth M, Behrens H, Stolte M (2003) Sporadic adenoma and colitis-associated intraepithelial neoplasia: a difficult differential diagnosis. Pathologe 24:36–43

    CAS  PubMed  Google Scholar 

  177. Voigt E, Griga T, Tromm A et al (1999) Polymyositis of the skeletal muscles as an extraintestinal complication in quiescent ulcerative colitis. Int J Colorectal Dis 14:304–307

    Article  CAS  PubMed  Google Scholar 

  178. von Herbay A (1999) Histopathologic diagnosis of chronic inflammatory intestinal diseases. Historical review and current survey. Pathologe 20:276–287

    Article  Google Scholar 

  179. von Herbay A (2001) Guidelines of the DGVS. Histopathological diagnosis. German Society of Digestive and Metabolic Diseases. Z Gastroenterol 39:25–27

    Article  Google Scholar 

  180. Wakefield AJ, Sawyerr AM, Dhillon AP et al (1989) Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction. Lancet 2:1057–1062

    Article  CAS  PubMed  Google Scholar 

  181. Wakefield AJ, Fox JD, Sawyerr AM et al (1992) Detection of herpesvirus DNA in the large intestine of patients with ulcerative colitis and Crohn's disease using the nested polymerase chain reaction. J Med Virol 38:183–190

    Article  CAS  PubMed  Google Scholar 

  182. Walgenbach S, Junginger T, Rothmund M et al (1987) Crohn disease and squamous cell carcinoma of the anorectal transition. Chirurg 58:248–251

    CAS  PubMed  Google Scholar 

  183. Walsh SV, Loda M, Torres CM et al. (1999) P53 and beta catenin expression in chronic ulcerative colitis–associated polypoid dysplasia and sporadic adenomas: an immunohistochemical study. Am J Surg Pathol 23: 963–969

    Google Scholar 

  184. Werlin SL, Glicklich M (1981) Miliary Crohn's disease. Am J Gastroenterol 75:48–51

    CAS  PubMed  Google Scholar 

  185. Werner M, Mueller E (1999) Dysplasia in ulcerative colitis. Verh Dtsch Ges Pathol 83:122–129

    CAS  PubMed  Google Scholar 

  186. Wester AL, Vatn MH, Fausa O (2001) Secondary amyloidosis in inflammatory bowel disease: a study of 18 patients admitted to Rikshospitalet University Hospital, Oslo, from 1962 to 1998. Inflamm Bowel Dis 7:295–300

    Article  CAS  PubMed  Google Scholar 

  187. Willenbucher RF, Aust DE, Chang CG et al (1999) Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia. Am J Pathol 154:1825–1830

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  188. Wong NA, Harrison DJ (2001) Colorectal neoplasia in ulcerative colitis-recent advances. Histopathology 39:221–234

    Article  CAS  PubMed  Google Scholar 

  189. Wurzelmann JI, Lyles CM, Sandler RS (1994) Childhood infections and the risk of inflammatory bowel disease. Dig Dis Sci 39:555–560

    Article  CAS  PubMed  Google Scholar 

  190. Yang H, McElree C, Roth MP et al (1993) Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews. Gut 34:517–524

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  191. Yoshida Y, Murata Y (1990) Inflammatory bowel disease in Japan: studies of epidemiology and etiopathogenesis. Med Clin North Am 74:67–90

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Daniela E. Aust Priv.-Doz. Dr. med.

    Present address: Institut für Pathologie, Bereichsleitung Obduktion, Universitätsklinikum Carl-Gustav-Carus an der TU Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland

Authors and Affiliations

    Authors
    1. Daniela E. Aust Priv.-Doz. Dr. med.
      View author publications

      You can also search for this author in PubMed Google Scholar

    Corresponding author

    Correspondence to Daniela E. Aust Priv.-Doz. Dr. med. .

    Editor information

    Editors and Affiliations

    1. Institut für Pathologie, Klinikum Kulmbach, Kulmbach, Germany

      Manfred Stolte

    2. Institut für Pathologie Nordhessen, Kassel, Germany

      Josef Rüschoff

    3. Konsultationszentrum für Pankreas- und, Technische Universität München Klinikum rechts der Isar, München, Germany

      Günter Klöppel

    Rights and permissions

    Reprints and permissions

    Copyright information

    © 2013 Springer-Verlag Berlin Heidelberg

    About this chapter

    Cite this chapter

    Aust, D.E. (2013). Chronisch-entzündliche Erkrankungen des Kolorektums. In: Stolte, M., Rüschoff, J., Klöppel, G. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02322-4_27

    Download citation

    • DOI: https://doi.org/10.1007/978-3-642-02322-4_27

    • Published:

    • Publisher Name: Springer, Berlin, Heidelberg

    • Print ISBN: 978-3-642-02321-7

    • Online ISBN: 978-3-642-02322-4

    • eBook Packages: Medicine (German Language)

    Publish with us

    Policies and ethics

    Search

    Navigation