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Aging: Evolutionary Theory Meets Genomic Approaches

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Evolutionary Biology

Abstract

Modern evolutionary theory describes aging as the result of an accumulation of late-acting, deleterious genes caused by reduced force of natural selection late in life, combined with selection for genes that are beneficial early in life but damaging late in life. Theories based on this logic predict that organisms will be optimized for overall fitness as opposed to maximum longevity. Recent advances in genomics combined with large-scale methods for single gene knockout in several common aging models have allowed the first genome-wide studies of life span. These studies provide insight into several aspects of the biology of aging that relate to evolution, including the scope of cellular processes that influence longevity and the conservation of longevity determinants between organisms. Here we review the evolution of the aging field over the past several years and the implications of the move toward genomics. We also highlight key results and discuss their importance and relation to evolutionary theories of aging.

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Authors and Affiliations

  1. Departments of Pathology, University of Washington, Seattle, WA, 98195, USA

    George L. Sutphin

  2. The Molecular and Cellular Biology Program, University of Washington, Seattle, WA, 98195, USA

    George L. Sutphin

  3. Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA

    Brian K. Kennedy

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Correspondence to George L. Sutphin .

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  1. CNRS UMR 6632, Université d'Aix-Marseille, place Victor Hugo 3, Marseille CX 03, 13331, France

    Pierre Pontarotti

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Sutphin, G.L., Kennedy, B.K. (2009). Aging: Evolutionary Theory Meets Genomic Approaches. In: Pontarotti, P. (eds) Evolutionary Biology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00952-5_20

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