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Adverse Drug Reactions Affecting Blood Cells

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Adverse Drug Reactions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 196))

Abstract

Numerous medications and other xenobiotics are capable of producing adverse reactions (ADRs) affecting red cells, platelets or neutrophils. Occasionally, more than one blood element is affected simultaneously. As with all drug reactions, some side effects are a direct consequence of a known pharmacologic action of the drug and are dose-dependent; others occur sporadically and relatively independent of dose. The latter (“idiosyncratic”) reactions are unpredictable and, in general, have no known underlying genetic basis. Many are antibody-mediated, as would be expected since cellular immune effector cells have little direct access to circulating blood cells. In this chapter, we will discuss idiosyncratic drug reactions affecting blood and blood forming tissues with an emphasis on those thought to be immune-mediated.

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Abbreviations

ADR:

Adverse drug reaction

AITP:

Autoimmune thrombocytopenic purpura

DDAb:

Drug-dependent antibody

DIHA:

Drug-induced immune hemolytic anemia

DITP:

Drug-induced immune thrombocytopenia

G-CSF:

Granulocyte colony simulating factor

HIT:

Heparin-induced thrombocytopenia

HUS:

Hemolytic uremic sundrome

NSAID:

Non-steroidal anti-inflammatory drug

RGD:

Arginine-glycine-aspartic acid

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Authors and Affiliations

  1. Blood Research Institute, Blood Center of Wisconsin, 2178 Watertown Plank Rd, Milwaukee, 53201, WI, USA

    Richard H. Aster

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  1. Richard H. Aster
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Correspondence to Richard H. Aster .

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Editors and Affiliations

  1. Faculty of Pharmacy, University of Toronto, Toronto, Canada, M5S 2S2

    Jack Uetrecht (Professor of Pharmacy and Medicine, Canada Research Chair in Adverse Drug Reactions) (Professor of Pharmacy and Medicine, Canada Research Chair in Adverse Drug Reactions)

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Aster, R.H. (2010). Adverse Drug Reactions Affecting Blood Cells. In: Uetrecht, J. (eds) Adverse Drug Reactions. Handbook of Experimental Pharmacology, vol 196. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00663-0_3

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