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Abstract

Tissue Engineering (or regenerative medicine) is a rapidly developing field of research pursued by very different branches of medicine. The most results are published by orthopedists [28] and cardiologists, but meanwhile, there is nearly no special subject that does not investigate in this area. Furthermore, there is a multitude of methods and techniques that are involved in tissue engineering. Therefore, it is difficult to define or to describe the scope of “tissue engineering” in one sentence.

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References

  1. ABIM, ACP-ASIM, European Federation of Internal Medicine (2002) Medical professionalism in the new millennium. A physician charter. Ann Internal Med 136(3):243–246

    Google Scholar 

  2. Abouna GM (2003) Ethical issues in organ and tissue transplantation. Med Princ Pract 12(1):54–69

    Article  PubMed  Google Scholar 

  3. Ach JS, Jömann N (2006) Ethical implications of nanobiotechnology. State-of-the-art survey of ethical issues related to nanobiotechnology. In: Siep L (eds) Nano-bio-ethics: ethical dimensions of nanobiotechnology. Münster, Germany: Lit pp 13–62

    Google Scholar 

  4. Baum BJ, Mooney DJ (2000) The impact of tissue engineering on dentistry. J Am Dental Assoc 131:309–318

    CAS  Google Scholar 

  5. Beauchamp TL, Childress JF (1994) Principles of biomedical ethics, 4th ed. Oxford University Press, New York

    Google Scholar 

  6. Birnbacher D (2007) Der Hirntod—eine pragmatische Verteidigung. Jahrbuch für Recht und Ethik 15:459–477

    Google Scholar 

  7. Black J (1997) Thinking twice about “tissue engineering”. IEEE Eng Med Biol Mag 16(4):102–104

    Article  PubMed  CAS  Google Scholar 

  8. Buchanan AE, Brock DW (1990) Deciding for others: the ethics of surrogate decision making. University Press, Cambridge

    Google Scholar 

  9. Daar AS, Bhatt A, Court E, Singer A (2004) Stem cell research and transplantation: science leading ethics. Transplant Proc 36:2504–2506

    Article  PubMed  CAS  Google Scholar 

  10. de Brugerolle A (2007) SkinEthic Laboratories, a company devoted to develop and produce In vitro alternative methods to anima use. ALTEX 24(3):167–171

    PubMed  Google Scholar 

  11. Denker HW (1999) Embryonic stem cells: an exciting field for basic research and tissue engineering, but also an ethical dilemma? Cells Tissues Organs 165:246–249

    Article  PubMed  CAS  Google Scholar 

  12. Dickens BM, Cook RJ (2007) Acquiring human embryos for stem cell research. Int J Gynaecol Obstet 96:67–71

    Article  PubMed  CAS  Google Scholar 

  13. European Group on Ethics (2004) Report of the European Group on Ethics on the Ethical Aspects of Human Tissue Engineered Products

    Google Scholar 

  14. Eyrich D, Brandl F, Appel B, Wiese H, Maier G, Wenzel M, Staudenmaier R, Goepferich A, Blunk T (2007) Long-term stable fibrin gels for cartilage engineering. Biomaterials 28:55–65

    Article  PubMed  CAS  Google Scholar 

  15. Faden RR, Beauchamp TL (1986) A history and theory of informed consent. Oxford, New York

    Google Scholar 

  16. Gelhaus P (2006) Gentherapie und Weltanschauung. Ein Überblick über die genethische Discussion. Wissenschaftlicher Buchverlag, Darmstadt

    Google Scholar 

  17. Gelhaus P (2007) Was bedeutet eigentlich “gesund” im medizinischen Umfeld? In: Jansen G, Schwarzfischer K (eds) Gesundheit-wozu? Jansen-Verlag, Lüneburg, pp 83–102

    Google Scholar 

  18. Gelhaus P (2008) Wie groß ist zu groß? Zur Funktionalität des Normalen. In: Groß D, Müller S, Steinmetzer J (eds) Normal—anders—krank? Akzeptanz, Stigmatisierung und Pathologisierung im Kontext der Medizin. Medizinisch-Wissenschaftliche Verlagsgesellschaft Berlin, pp 33–49

    Google Scholar 

  19. Gelhaus P, Middel CD (2002) “Individuelle Gesundheit versus public health?!” ein Streitgespräch zur Forschungsentwicklung am Beispiel der revidierten Deklaration von Helsinki (Edinburgh 2000). In: Brand A, Engelhardt DV, Simon A, Wehkamp KH, (eds) Individuelle Gesundheit versus public health? Münster, London, pp 96–112

    Google Scholar 

  20. Gordijn B (2004) Medizinische Utopien. Eine ethische Betrachtung. Vandenhoeck & Ruprecht Göttingen, pp 65–110

    Google Scholar 

  21. Green RM (2002) Benefiting from “evil”: an incipient moral problem in human stem cell research. Bioethics 16(6):544–556

    Article  PubMed  Google Scholar 

  22. Green RM (2004) Ethical considerations. In: Lanza R, et al. (eds) Handbook of stem cells. Elsevier, Amsterdam, pp 759–764

    Chapter  Google Scholar 

  23. Hammerman MR, Cortesini R (2004) Organogenesis and tissue engineering.Transpl Immunol 12:191–192

    Article  PubMed  Google Scholar 

  24. Heinonen M, Oila O, Nordström K (2005) Current issues in the regulation of human tissue-engineering products in the European Union. Tissue Eng 11(11/12):1905–1911

    Article  PubMed  Google Scholar 

  25. Henon PR:(2003) Human embryonic or adult stem cells: an overview on ethics and perspectives for tissue engineering. Adv Exp Med Biol 534:27–45

    PubMed  Google Scholar 

  26. Hunziker EB (2003) Tissue engineering of bone and cartilage. From the preclinical model to the patient. Novartis Found Symp 249:70–78

    Article  PubMed  Google Scholar 

  27. Langer R, Vacanti JP (1993) Tissue engineering. Science 260:920–926

    Article  PubMed  CAS  Google Scholar 

  28. Lohmander LS (2003) Tissue engineering of cartilage: do we need it, can we do it, is it good and can we prove it? Novartis Found Symp 249:2–10

    Article  PubMed  Google Scholar 

  29. Longley D, Lawford P (2001) Engineering human tissue and regulation: confronting biology and law to bridge the gaps. Med Law Int 5:101–115

    PubMed  CAS  Google Scholar 

  30. Meyer T (2005) Ethical considerations in bone and cartilage tissue engineering. Meyer U, Wiesmann HP (eds) Bone and cartilage engineering. Springer, Berlin, pp 203–206

    Google Scholar 

  31. Nationaler Ethikrat (Germany) (2007) Zur Frage einer Änderung des Stammzellgesetzes. Stellungnahme, www.ethikrat.org/stellungnahmen/pdf/stn-stammzellgesetz.pdf (access: 03–06–2008)

    Google Scholar 

  32. Nordgren A (2004) Moral imagination in tissue engineering research on animal models. Biomaterials 25:1723–1734

    Article  PubMed  CAS  Google Scholar 

  33. Reed JA, Patarca R (2006) Regenerative dental medicine: stem cells and tissue engineering in dentistry. J Environ Pathol Toxicol Oncol 25(3):537–569

    PubMed  Google Scholar 

  34. San Martin A, Borlongan CV (2006) Cell transplantation: toward cell therapy. Cell Transplant 15:665–673

    Article  Google Scholar 

  35. Satava RM (2002) Disruptive visions. Moral and ethical challenges from advanced technologies and issues for the new generation of surgeons. Surg Endosc 16:1403–1408

    Article  PubMed  CAS  Google Scholar 

  36. Satava RM (2003) Biomedical, ethical, and moral issues being forced by advanced medical technologies. Proc Am Philos Soc 147(3):246–258

    PubMed  Google Scholar 

  37. Schilling AF, Linhart W, Filke S, Gebauer M, Schinke T, Rueger JM, Amling M (2004) Resorbability of bone substitute biomaterials by human osteoclasts. Biomaterials 25:3963–3972

    Article  PubMed  CAS  Google Scholar 

  38. Schöne-Seifert B, Ach JS, Siep L (2006) Totipotenz und Potentialität. Zum moralischen Status von Embryonen bei unterschiedlichen Varianten der Gewinnung humaner embryonaler Stammzellen. Gutachten für das Kompetenznetzwerk Stammzellforschung NRW. Jahrbuch für Wissenschaft und Ethik 11:261–321

    Google Scholar 

  39. Schwab IR, Johnson NT, Harkin DG (2006) Inherent risks associated with manufacture of bioengineered ocular surface tissue. Arch Ophtalmol 124:1734–1740

    Article  Google Scholar 

  40. Siep L (2006) Ethical problems of stem cell research and stem cell transplantation, In: Deltas C, Kalokairinou EM, Rogge S (eds) Progress in science and the danger of hybris. Waxmann, Münster, pp 91–99

    Google Scholar 

  41. Singer P (1975) Animal liberation: a new ethics for our treatment of animals. Random House, New York

    Google Scholar 

  42. Singer P (1993) Practical Ethics 2nd ed. Cambridge, New York

    Google Scholar 

  43. Stanworth SJ, Newland AC (2001) Stem cells: progress in research and edging towards the clinical setting. Clin Med 1(5):378–382

    PubMed  CAS  Google Scholar 

  44. Steinbock B (2007) Moral status, moral value and human embryos: implications for stem cell research. In: Steinbock B (ed) The Oxford handbook of bioethics. Oxford, New York, pp 416–440

    Google Scholar 

  45. Sutherland FWH, Mayer JE Jr (2003) Ethical and regulatory issues concerning engineered tissues for congenital heart repair. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 6:152–163

    Article  PubMed  Google Scholar 

  46. Sylvester KG, Longaker MT (2004) Stem cells. Arch Surg 139:93–99

    Article  PubMed  Google Scholar 

  47. Takala T, Häyry M (2007) Benefiting from past wrongdoing, human embryonic stem cells and the fragility of the German legal position. Bioethics 21:150–159

    Article  PubMed  Google Scholar 

  48. Trommelmans L, Selling J, Dierickx K (2007) A critical assessment of the directive on tissue engineering of the European Union. Tissue Eng 13(4):667–672

    Article  PubMed  Google Scholar 

  49. Vats A, Tolley NS, Polak JM, Buttery LDK (2002) Stem cells: sources and applications. Clin Otolaryngol Allied Sci 27:227–232

    Article  PubMed  CAS  Google Scholar 

  50. Weyr S (1993) Informed consent: patient autonomy and physician beneficence within clinical medicine. Kluwer, Dordrecht

    Google Scholar 

  51. Williams D (2006) A registry for tissue engineering clinical trials, In: Med Device Technol 5:8–10

    Google Scholar 

  52. World Medical Association (1964, 1975, 1983, 1989, 1996, 2000, 2004) Declaration of Helsinki

    Google Scholar 

  53. Zoloth L (2004) Immortal cells, moral selves. In: Lanza R, et al. (eds.) Handbook of stem cells, vol 1. Elsevier, Amsterdam, pp 747–757

    Chapter  Google Scholar 

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Gelhaus, P. (2009). Ethical Issues in Tissue Engineering. In: Meyer, U., Handschel, J., Wiesmann, H., Meyer, T. (eds) Fundamentals of Tissue Engineering and Regenerative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77755-7_3

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  • DOI: https://doi.org/10.1007/978-3-540-77755-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

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