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MS Lesions in T2-Weighted Images

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MRI Atlas of MS Lesions

Abstract

Multiple hyperintense lesions on T2- and PD-weighted sequences are the characteristic magnetic resonance imaging (MRI) appearance of multiple sclerosis (MS). The majority of the lesions are small, although they can occasionally measure several centimeters in diameter. Focal MS lesions are usually round or oval in shape and relatively well circumscribed.

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References

  1. Barkhof F (1999) MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS). Mult Scler 5:283–286

    PubMed  CAS  Google Scholar 

  2. Brownell B, Hughes JT (1962) The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry 25:315–320

    Article  PubMed  CAS  Google Scholar 

  3. Bruck W, Bitsch A, Kolenda H et al (1997) Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 42:783–793

    Article  PubMed  CAS  Google Scholar 

  4. Ciccarelli O, Werring DJ, Wheeler-Kingshott CA et al (2001) Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations. Neurology 56:926–933

    PubMed  CAS  Google Scholar 

  5. De Groot CJ, Bergers E, Kamphorst W et al (2001) Post-mortem MRI-guided sampling of multiple sclerosis brain lesions: increased yield of active demyelinating and (p) reactive lesions. Brain 124:1635–1645

    Article  PubMed  Google Scholar 

  6. De Stefano N, Narayanan S, Francis SJ et al (2002) Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability. Arch Neurol 59:1565–1571

    Article  PubMed  Google Scholar 

  7. Ge Y (2006) Multiple sclerosis: the role of MR imaging. AJNR Am J Neuroradiol 27:1165–1176

    PubMed  CAS  Google Scholar 

  8. Goodin DS (2006) Magnetic resonance imaging as a surrogate outcome measure of disability in multiple sclerosis: have we been overly harsh in our assessment? Ann Neurol 59:597–605

    Article  PubMed  Google Scholar 

  9. Kidd D, Barkhof F, McConnell R et al (1999) Cortical lesions in multiple sclerosis. Brain 122:17–26

    Article  PubMed  Google Scholar 

  10. O’Riordan JI, Thompson AJ, Kingsley DP et al (1998) The prognostic value of brain MRI in clinically isolated syndromes of the CNS: a 10-year follow-up. Brain 121:495–503

    Article  PubMed  Google Scholar 

  11. Ormerod IE, Miller DH, McDonald WI et al (1987) The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions: a quantitative study. Brain 110:1579–1616

    Article  PubMed  Google Scholar 

  12. Ostuni JL, Richert ND, Lewis BK et al (1999) Characterization of differences between multiple sclerosis and normal brain: a global magnetization transfer application. AJNR Am J Neuroradiol 20:501–507

    PubMed  CAS  Google Scholar 

  13. Paty DW (1998) Magnetic resonance imaging in the assessment of disease activity in multiple sclerosis. Can J Neurol Sci 15:266–272

    Google Scholar 

  14. Peterson JW, Bo L, Mork S et al (2001) Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 50:389–400

    Article  PubMed  CAS  Google Scholar 

  15. Rovaris M, Comi G, Ladkani D et al (2003) Short-term correlations between clinical and MR imaging findings in relapsing-remitting multiple sclerosis. AJNR Am J Neuroradiol 24:75–81

    PubMed  Google Scholar 

  16. Simon JH, Li D, Traboulsee A et al (2006) Standardized MR imaging protocol for multiple sclerosis: Consortium of MS Centers consensus guidelines. AJNR Am J Neuroradiol 27:455–461

    PubMed  CAS  Google Scholar 

  17. Smith ME, Stone LA, Albert PS et al (1993) Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions. Ann Neurol 33:480–489

    Article  PubMed  CAS  Google Scholar 

  18. Stewart WA, Hall LD, Berry K et al (1984) Correlation between NMR scan and brain slice data in multiple sclerosis. Lancet 2:412

    Article  PubMed  CAS  Google Scholar 

  19. Thorpe JW, Kidd D, Moseley IF et al (1996) Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis. Neurology 46:373–378

    PubMed  CAS  Google Scholar 

  20. Zhao GJ, Koopmans RA, Li DK et al (2000) Effect of interferon beta-1b in MS: assessment of annual accumulation of proton density (PD)/T2 activity on MRI. UBC MS/MRI Analysis Group and the MS Study Group. Neurology 11:200–206

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Hassan Abad Square, Tehran, Iran, Islamic Republic of

    Mohammad Ali Sahraian

  2. Head of Department of Neuroradiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland

    Ernst-Wilhelm Radue

Authors
  1. Mohammad Ali Sahraian
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  2. Ernst-Wilhelm Radue
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Editor information

Editors and Affiliations

  1. Head of Department of Neuroradiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland

    Ernst-Wilhelm Radü

  2. Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Hassan Abad Square, Tehran, Iran, Islamic Republic of

    Mohammad Ali Sahraian

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© 2007 Springer-Verlag Berlin Heidelberg

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Sahraian, M., Radue, EW. (2007). MS Lesions in T2-Weighted Images. In: Radü, EW., Sahraian, M. (eds) MRI Atlas of MS Lesions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71372-2_1

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  • DOI: https://doi.org/10.1007/978-3-540-71372-2_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-71371-5

  • Online ISBN: 978-3-540-71372-2

  • eBook Packages: MedicineMedicine (R0)

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