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Nucleocytoplasmic RNA Transport in Retroviral Replication

  • Chapter
Cell Polarity and Subcellular RNA Localization

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 34))

Abstract

Cellular gene expression is a highly ordered, stepwise process. Genetic information is transcribed in the cell nucleus into a pre-mRNA. Subsequently, this primary transcript is extensively modified on a post-transcriptional level. Intronic, non coding sequences are removed by splicing, a cap structure is added to the 5’end, and the 3’end is modified by cleavage and polyadenylation. A hallmark of all cellular gene expression is retention of the transcript in the nucleus during the entire process of modification. Only the completely processed mature RNA molecule is exported into the cytoplasm, where translation occurs.

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  1. Hans-Georg Kräusslich

    Present address: Abteilung Virologie, Universität Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany

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  1. Heinrich-Pette-Institut für experimentelle Virologie und Immunologie, Universität Hamburg, 20251, Hamburg, Germany

    Harald Wodrich

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  1. Institut für Zellbiochemie und klinische Neurobiologie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 20246, Hamburg, Germany

    Dietmar Richter

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Wodrich, H., Kräusslich, HG. (2001). Nucleocytoplasmic RNA Transport in Retroviral Replication. In: Richter, D. (eds) Cell Polarity and Subcellular RNA Localization. Results and Problems in Cell Differentiation, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-40025-7_12

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  • DOI: https://doi.org/10.1007/978-3-540-40025-7_12

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