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Cardiac Extracellular Matrix pp 199–211Cite as

Clinical Trial Design for Investigational Cardio-Regenerative Therapy

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1098))

Abstract

Human trials of cardio-regenerative biologic therapies are being performed worldwide to address a growing, unmet need for durable treatments of cardiovascular disease. A well-constructed clinical trial design for these novel therapies requires careful attention to defining a clear hypothesis, a patient population, and anticipated outcomes. The scope of screening, method of randomization, blinding approach, data monitoring, and statistical analysis plan are the foundational elements that must be addressed in any clinical trial. Although the experience of human trials involving extracellular matrix constructs for cardiovascular disease treatment is limited, numerous lessons have been learned in the field of cell therapy that are translatable across all biologic treatment options. Future progress in this field may include testing combinations of cells, gene-transfer agents, and matrix and identifying treatment responders versus nonresponders.

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Author information

Authors and Affiliations

  1. School of Medicine & Public Health, University of Wisconsin-Madison, Madison, WI, USA

    Amish N. Raval

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  1. Amish N. Raval
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Correspondence to Amish N. Raval .

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Editors and Affiliations

  1. School of Medicine & Public Health, University of Wisconsin-Madison, Madison, WI, USA

    Eric G. Schmuck

  2. School of Medicine & Public Health, University of Wisconsin-Madison, Madison, WI, USA

    Peiman Hematti

  3. School of Medicine & Public Health, University of Wisconsin-Madison, Madison, WI, USA

    Amish N. Raval

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Raval, A.N. (2018). Clinical Trial Design for Investigational Cardio-Regenerative Therapy. In: Schmuck, E., Hematti, P., Raval, A. (eds) Cardiac Extracellular Matrix. Advances in Experimental Medicine and Biology, vol 1098. Springer, Cham. https://doi.org/10.1007/978-3-319-97421-7_11

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