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Acalabrutinib, A Second-Generation Bruton’s Tyrosine Kinase Inhibitor

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Small Molecules in Hematology

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 212))

Abstract

The Bruton’s tyrosine kinase (BTK) is an essential in the B-cell receptor (BCR) signaling pathway which was identified as crucial in the pathogenesis of B-cell malignancies. Ibrutinib, a first-in-class BTK inhibitor, has been approved for the treatment of distinct B-cell malignancies. To overcome off-target side effects of and emerging resistances to ibrutinib, more selective second-generation BTK inhibitors were developed. Acalabrutinib is a novel second-generation BTK inhibitor and has shown promising safety and efficacy profiles in phase 1/2 clinical trials in patients with relapsed CLL and pretreated MCL. Recently, acalabrutinib was approved by the FDA for treatment of adult patients with MCL who received at least one prior therapy. However, clinical trials on a direct comparison between ibrutinib and acalabrutinib and on combination treatment options with other agents as CD20 antibodies are warranted.

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Authors and Affiliations

  1. Department of Hematology, Oncology and Rheumatology, Heidelberg University, Heidelberg, Germany

    Katharina Kriegsmann & Mathias Witzens-Harig

  2. Institute of Pathology, Heidelberg University, Heidelberg, Germany

    Mark Kriegsmann

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  1. Katharina Kriegsmann
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  2. Mark Kriegsmann
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  3. Mathias Witzens-Harig
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Correspondence to Katharina Kriegsmann .

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Editors and Affiliations

  1. MOLIT Institute, Cancer Center Heilbronn-Franken, SLK-Clinics, Heilbronn, Baden-Württemberg, Germany

    Uwe M. Martens

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Kriegsmann, K., Kriegsmann, M., Witzens-Harig, M. (2018). Acalabrutinib, A Second-Generation Bruton’s Tyrosine Kinase Inhibitor. In: Martens, U. (eds) Small Molecules in Hematology. Recent Results in Cancer Research, vol 212. Springer, Cham. https://doi.org/10.1007/978-3-319-91439-8_14

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  • DOI: https://doi.org/10.1007/978-3-319-91439-8_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-91438-1

  • Online ISBN: 978-3-319-91439-8

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