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The Diabetic Foot pp 247–256Cite as

Tissue-Engineered Wound Dressings for Diabetic Foot Ulcers

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Part of the book series: Contemporary Diabetes ((CDI))

Abstract

With the rise in the number of individuals suffering from diabetes, a greater number of patients are at risk of developing diabetic foot ulcers (DFUs). While traditional wound therapies can be successful at treating moderate DFUs when detected early, they often fall short in treating more severe cases which can lead to secondary ulcer formation or lower extremity amputations. To remedy this, a number of FDA-approved therapies have been developed and approved in the past two decades that take advantage of advances in biomaterials and tissue engineering to manufacture materials that have specific functionalities, and exploit active dressing materials that can enhance the wound healing process for these patients. Despite these advances, diabetic patients still suffer from slow healing wounds that often lead to further infections and delayed healing and/or amputations. Recent research in the wound healing field has focused on developing dressings with improved properties, especially the ability to encapsulate and release therapeutics over prolonged durations. These can potentially enhance the wound healing process by controlling cell migration and proliferation into the wound and provide a physiochemical environment conducive to healing. While many of these therapies are still undergoing clinical testing, or have yet to be tested for the treatment of DFUs, they provide a promising future.

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Authors and Affiliations

  1. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA

    Sahar Rahmani PhD & David J. Mooney PhD

  2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA

    Sahar Rahmani PhD & David J. Mooney PhD

Authors
  1. Sahar Rahmani PhD
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  2. David J. Mooney PhD
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Correspondence to David J. Mooney PhD .

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Editors and Affiliations

  1. Rongxiang Xu, MD, Professor of Surgery, Harvard Medical School Director, The Rongxiang Xu, MD, Center for Regenerative Therapeutics Research Director, Joslin-Beth Israel Deaconess Foot Center Beth Israel Deaconess Medical Center, Boston, MA, USA

    Aristidis Veves

  2. Chief, Division of Podiatry, Beth Israel Deaconess Medical Center, Associate Professor of Surgery, Harvard Medical School, Co-director, Joslin-Bl Deaconess Diabetic Foot Center Consultant, Joslin Diabetes Center, Boston, MA, USA

    John M. Giurini

  3. Associate Professor of Surgery, Harvard Medical School, Division of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Joslin Diabetes Center, Boston, MA, USA

    Raul J. Guzman

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Rahmani, S., Mooney, D.J. (2018). Tissue-Engineered Wound Dressings for Diabetic Foot Ulcers. In: Veves, A., Giurini, J., Guzman, R. (eds) The Diabetic Foot. Contemporary Diabetes. Humana, Cham. https://doi.org/10.1007/978-3-319-89869-8_15

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  • DOI: https://doi.org/10.1007/978-3-319-89869-8_15

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