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Molecular Mechanisms of Notch Signaling pp 99–122Cite as

Endocytic Trafficking of the Notch Receptor

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1066))

Abstract

The endosomal pathway plays an important role in several aspects of Notch signalling ranging from ligand-dependent to independent activation and also degradation of the Notch receptor. Here, we will focus on its role during receptor degradation and describe the endosomal pathway with the components that are important for Notch degradation and the molecular machinery that orchestrates these events. Subsequently, we will describe the journey of Notch through the endosomal system and discuss the role of the genes involved. Mechanisms of the recently discovered ligand-independent activation of the Notch receptor in the endosomal pathway will be described and its contribution in physiologically Notch-dependent processes will be discussed. Last but not least, we will summarize the evidence for endosomal ligand-independent activation of the Notch pathway in vertebrates.

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Abbreviations

AAA-ATPase:

ATPase Associated with diverse cellular Activities

ADAM10:

A Disintegrin and metalloprotease 10

Aki1:

Akt Kinase-Interacting Protein 1

ANK:

Ankyrin

AP:

Adaptor Protein

CADASIL:

Cerebral Autosomal Dominant Artheriopathy with Subcortical Infarcts and Leukoencephalopathy

Cbl:

Casistas B-lineage lymphoma

CC2D1A:

Coiled-Coil and C2 domain-containing protein 1A

CC2D1B:

Coiled-Coil and C2 domain-containing protein 1B

CCZ1:

Calcium-Caffeine-zinc sensititivity protein

CHMP:

Charged multivesicular body protein

COMMD9:

COMM (Copper metabolism) domain containing protein 9

CORVET:

class C core vacuole/endosome tethering

Crb:

Crumbs

CSL:

CBF-1, Suppressor of Hairless, LAG-1

Dl:

Delta

Dll3:

Delta-like 3

DM14:

Drosophila melanogaster 14

dNedd4:

Neural precursor cell expressed developmentally downregulated protein 4

DSL:

(Delta/Serrate/LAG-2)

Dx:

Deltex

EE:

Early Endosome

EE2A:

early endosomal antigene 2

EEVs:

Early Endosomal Vesicles

EGF:

Epidermal growth factor

ESCRT:

Endosomal sorting complex required for transport

FGF:

Fibroblast growth factor

Freud-1:

FRE under Dual Repression-Binding-Protein 1

Freud-2:

FRE under Dual Repression-Binding-Protein 2

FYVE:

Fab1 YOTB VAC1 EEA1

GAP:

GTPase activating protein

GDF:

GTPase dissociation factor

GDI:

GDP-dissociation inhibitor

GDP:

Guanosine diphosphate

GEF:

Guanine nucleotide exchange factor

GFP:

Green fluorescent protein

GPI:

Glycosylphosphatidylinositol

GTP:

Guanosine triphosphate

HOPS:

homotypic fusion and protein sorting

Hrs:

Hepatocyte growth factor-regulated tyrosine kinase substrate

Hsc70:

Heat shock cognate70

ICD:

intracellular domain

ILV:

intraluminal vesicle

Kuz:

Kuzbanian

Lamp:

Lysosome-associated membrane glycoprotein

Lgd:

Lethal giant discs

LNR:

Lin-12 / Notch repeat

ME:

Maturing Endosome

Mon1:

Monensin sensitivity protein 1

MVB:

Multivesicular body

NECD:

Notch extracellular domain

NEXT:

Notch extracellular truncation

NICD:

Notch intracellular domain

NRR:

Negative Regulatory Region

PEST:

Proline (P), Glutamic acid (E), Serine (S), Threonin(T)

PI(3,5)P2:

Phosphatidylinositol 3,5-bisphoshphate

PI3P:

Phosphatidylinositol 3-phosphate

Rab:

ras-related in brain

RAM:

RBPJ-associated molecule

RBPJ:

recombination signal binding protein for immunoglobulin kappa J region

RE:

Recycling Endosome

RME8:

Receptor mediated Endocytosis 8

Ser:

Serrate

Shrb:

Shrub

SNARE:

soluble N-ethylmaleimide-sensitive-factor attachment receptor

SNX:

Sorting nexin

Stam:

Signal transducing adaptor molecule

Su(Dx):

Suppressor of Deltex

Su(H):

Suppressor of Hairless

TAPE:

TBK1-associated Protein in Endolysosomes

TMPs:

Transmembrane proteins

Tsg101:

tumor susceptibility gene 101

Ub:

Ubiquitin

UIM:

ubiquitin interacting motif

Vps:

Vacoular protein sorting

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Acknowledgments

Work in the Klein lab is supported by the Deutsche Forschungsgemeinschaft (DFG) through SFB 1208 “Identity and Dynamics of Membrane Systems-from Molecules to Cellular Functions “and Sachbeihilfe KL-1028/9-1 and KL-1028/8-1. We apologise to every researchers whose publications are not cited due to restrictions in space.

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  1. Institute of Genetics, Heinrich-Heine-University, Duesseldorf, Germany

    Björn Schnute, Tobias Troost & Thomas Klein

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  1. Björn Schnute
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Correspondence to Thomas Klein .

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  1. Institute of Biochemistry, University of Giessen, Giessen, Germany

    Tilman Borggrefe

  2. Institute of Biochemistry, University of Giessen, Giessen, Germany

    Benedetto Daniele Giaimo

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Schnute, B., Troost, T., Klein, T. (2018). Endocytic Trafficking of the Notch Receptor. In: Borggrefe, T., Giaimo, B. (eds) Molecular Mechanisms of Notch Signaling. Advances in Experimental Medicine and Biology, vol 1066. Springer, Cham. https://doi.org/10.1007/978-3-319-89512-3_6

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