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Handbook of Cancer Survivorship pp 129–144Cite as

Fatigue

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Abstract

Cancer-related fatigue (CRF) occurs in up to 90% of patients receiving cancer treatment and in 30–40% of cancer survivors. In this chapter, we describe the instruments that have been developed to identify CRF. Although the measurement of CRF is not standardized, clinicians are encouraged to incorporate CRF assessment in clinical practice. We also summarize the ongoing research demonstrating the association of inflammatory cytokines and CRF as well as other proposed mechanisms. We also suggest that exercise and psychological interventions, which have consistently demonstrated benefits in treating CRF, be utilized in the initial management of CRF. Finally, we summarize guidelines proposed by the American Society of Clinical Oncology, National Comprehensive Cancer Network, and Pan-Canadian Clinical Practice Guidelines for clinicians and health professionals in the screening, assessment, and treatment of CRF.

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Authors and Affiliations

  1. University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY, USA

    Karen M. Mustian

  2. University of Rochester, Surgery-Cancer Control, University of Rochester Medical Center, Rochester, NY, USA

    Po-Ju Lin

  3. James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA

    Kah Poh Loh

  4. Department of Surgery, Cancer Control (SMD), University of Rochester Medical Center, Rochester, NY, USA

    Ian R. Kleckner

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  1. Karen M. Mustian
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  2. Po-Ju Lin
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  3. Kah Poh Loh
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  4. Ian R. Kleckner
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Correspondence to Karen M. Mustian .

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Editors and Affiliations

  1. Professor (ret), Uniformed Services University Founder, Editor in Chief, Journal of Cancer Survivorship: Research and Practice, Bethesda, MD, USA

    Michael Feuerstein

  2. Department of Medicine, Brigham & Women’s Hospital, Perini Family Survivors’ Center, Dana-Farber Cancer Institute, Boston, MA, USA

    Larissa Nekhlyudov

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Mustian, K.M., Lin, PJ., Loh, K.P., Kleckner, I.R. (2018). Fatigue. In: Feuerstein, M., Nekhlyudov, L. (eds) Handbook of Cancer Survivorship. Springer, Cham. https://doi.org/10.1007/978-3-319-77432-9_8

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