Abstract
Commonly, pediatric hemato-oncologists are not accustomed to the peculiarities of drug therapy in neonatology, and so they need to pay attention to the issue of drug excipients—just as they should pay attention to avoiding preservative administration to neonates and infants.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Schmidt CWP, Menezes FG. Drug therapy and interactions in pediatric oncology: a pocket guide. Switzerland: Springer; 2017.
Kalász H, Antal I. Drug excipients. Curr Med Chem. 2006;13(21):2535–63.
Yasaka WJ, Eichbaum FW, Oga S. Antiarrhythmic effects of solvents: III. Effects of propylene glycol and benzyl alcohol on contractile force of isolated rabbit heart. Cardiovasc Res. 1979;13(12):717–22. http://cardiovascres.oxfordjournals.org/content/13/12/717.long. Accessed 3 Oct 2016.
Allegaert K. Neonates need tailored drug formulations. World J Clin Pediatr. 2013;2(1):1–5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145637. Accessed 6 Oct 2016.
Agency for Toxic Substances and Disease Registry: Toxic Substances Portal. 2011. https://www.atsdr.cdc.gov/substances/toxsubstance.asp?toxid=240. Accessed 3 Oct 2016.
Nair B. Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate. Int J Toxicol. 2001;20(Suppl 3):23–50.
Masi S, de Cléty SC, Anslot C, Detaille T. Acute amiodarone toxicity due to an administration error: could excipient be responsible? Br J Clin Pharmacol. 2009;67(6):691–3.
Graham S, Turner M. European Study of Neonatal Exposure to Excipients (ESNEE). Inf Dent. 2011;7(6):196–9. http://www.infantgrapevine.co.uk/pdf/inf_042_ien.pdf. Accessed 3 Oct 2016.
Taketomo C, Hodding J, Kraus D. Pediatric & neonatal dosage handbook. 21st ed. Hudson: Lexicomp; 2014.
PubChem: Compound Summary. https://pubchem.ncbi.nlm.nih.gov/compound/443315#section=Top. Accessed 3 Oct 2016.
Drugs.com. https://www.drugs.com. Accessed 1 Nov 2016.
Lass J, Naelapää K, Shah U, et al. Hospitalised neonates in Estonia commonly receive potentially harmful excipients. BMC Pediatr. 2012;12:136.
Kuschel C, Rowley S, Hughes B. Newborn services drug protocol: morphine hydrochloride. Auckland District Health Board. http://www.adhb.govt.nz/newborn/DrugProtocols/MorphineHydrochloridePharmacology.htm. Accessed 10 Jan 2017.
Li Q, Shu Y. Role of solute carriers in response to anticancer drugs. Mol Cell Ther. 2014;2:15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452062.
Harvey RA, Mycek MJ. Farmacologia ilustrada. 5th ed. Porto Alegre: Artmed; 2013.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Penteado Schmidt, C.W. (2018). Toxicity. In: Chemotherapy in Neonates and Infants. Springer, Cham. https://doi.org/10.1007/978-3-319-70591-0_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-70591-0_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-70590-3
Online ISBN: 978-3-319-70591-0
eBook Packages: MedicineMedicine (R0)