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Current Common Dilemmas in Colorectal Surgery pp 107–112Cite as

Fulminant Clostridium difficile Colitis: Indications and Extent of Surgery

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Abstract

Clostridium difficile infection has a significant impact on patients. It is the most common cause of healthcare-associated infection in hospital and the number one cause of antibiotic-induced diarrhea. C. difficile infection is associated with high morbidity and mortality rate in particular among elderly population and immunocompromised patients. Operative management is still the gold standard in severe and complicated cases, which in itself is associated with significant morbidity and mortality.

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References

  1. Hall I, O’Toole E. Intestinal flora in new-born infants with a description of a new pathogenic anaerobe, Bacillus difficilis. Am J Dis Child. 1935;49:390–402.

    Article  Google Scholar 

  2. Poli A, Di Matteo S, Bruno GM, Fornai E, Valentino MC, Colombo GL. Economic burden of Clostridium difficile in five hospitals of the Florence health care system in Italy. Risk Manag Healthc Policy. 2015;8:207–13.

    PubMed  PubMed Central  Google Scholar 

  3. Li X, Wilson M, Nylander W, Smith T, Lynn M, Gunnar W. Analysis of morbidity and mortality outcomes in postoperative clostridium difficile infection in the veterans health administration. JAMA Surg. 2016;151(4):314–22.

    Article  PubMed  Google Scholar 

  4. Di Bella S, Ascenzi P, Siarakas S, Petrosillo N, di Masi A. Clostridium difficile toxins A and B: insights into pathogenic properties and extraintestinal effects. Toxins. 2016;8(5):134.

    Article  PubMed Central  Google Scholar 

  5. Clabots CR, Johnson S, Olson MM, Peterson LR, Gerding DN. Acquisition of Clostridium difficile by hospitalized patients: evidence for colonized new admissions as a source of infection. J Infect Dis. 1992;166(3):561–7.

    Article  CAS  PubMed  Google Scholar 

  6. Smith LD, King EO. Occurrence of Clostridium difficile in infections of man. J Bacteriol. 1962;84:65–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Hafiz S, Oakley CL. Clostridium difficile: isolation and characteristics. J Med Microbiol. 1976;9(2):129–36.

    Article  CAS  PubMed  Google Scholar 

  8. George RH, Symonds JM, Dimock F, Brown JD, Arabi Y, Shinagawa N, et al. Identification of clostridium difficile as a cause of pseudomembranous colitis. Br Med J. 1978;1(6114):695.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Kappas A, Shinagawa N, Arabi Y, Thompson H, Burdon D, Dimock F, et al. Diagnosis of pseudomembranous colitis. Br Med J. 1978;1(6114):675–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Talbot RW, Walker RC, Beart RW. Changing epidemiology, diagnosis, and treatment of Clostridium difficile toxin-associated colitis. Br J Surg. 1986;73(6):457–60.

    Article  CAS  PubMed  Google Scholar 

  11. Smits WK, Lyras D, Lacy DB, Wilcox MH, Kuijper EJ. Clostridium difficile infection. Nat Rev Dis Primers. 2016;2:16020.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Chitnis AS, Holzbauer SM, Belflower RM, Winston LG, Bamberg WM, Lyons C, et al. Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011. JAMA Intern Med. 2013;173(14):1359–67.

    Article  PubMed  Google Scholar 

  13. Burnham CA, Carroll KC. Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories. Clin Microbiol Rev. 2013;26(3):604–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Burnham CA, Dubberke ER, Kociolek LK, Polage CR, Riley TV. Clostridium difficile-diagnostic and clinical challenges. Clin Chem. 2016;62(2):310–4.

    Article  CAS  PubMed  Google Scholar 

  15. Surawicz CM, Brandt LJ, Binion DG, Ananthakrishnan AN, Curry SR, Gilligan PH, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol. 2013;108(4):478–98. quiz 99

    Article  CAS  PubMed  Google Scholar 

  16. Debast SB, Bauer MP, Kuijper EJ. Diseases ESoCMaI. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clin Microbiol Infect. 2014;20(Suppl 2):1–26.

    Article  CAS  PubMed  Google Scholar 

  17. Kautza B, Zuckerbraun BS. The surgical management of complicated clostridium difficile infection: alternatives to colectomy. Surg Infect. 2016;17(3):337–42.

    Article  Google Scholar 

  18. Ogielska M, Lanotte P, Le Brun C, Valentin AS, Garot D, Tellier AC, et al. Emergence of community-acquired Clostridium difficile infection: the experience of a French hospital and review of the literature. Int J Infect Dis. 2015;37:36–41.

    Article  PubMed  Google Scholar 

  19. Keller PM, Weber MH. Rational therapy of clostridium difficile infections. Viszeralmedizin. 2014;30(5):304–9.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Kociolek LK, Bovee M, Carter D, Ciolino JD, Patel R, O'Donnell A, et al. Impact of a healthcare provider educational intervention on frequency of clostridium difficile polymerase chain reaction testing in children: a segmented regression analysis. J Pediatric Infect Dis Soc. 2016;6(2):142–8.

    Google Scholar 

  21. Lübbert C. Antimicrobial therapy of acute diarrhoea: a clinical review. Expert Rev Anti-Infect Ther. 2016;14(2):193–206.

    Article  PubMed  Google Scholar 

  22. Ofosu A. Clostridium difficile infection: a review of current and emerging therapies. Ann Gastroenterol. 2016;29(2):147–54.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Ash L, Baker ME, O’Malley CM, Gordon SM, Delaney CP, Obuchowski NA. Colonic abnormalities on CT in adult hospitalized patients with Clostridium difficile colitis: prevalence and significance of findings. AJR Am J Roentgenol. 2006;186(5):1393–400.

    Article  PubMed  Google Scholar 

  24. Lübbert C, John E, von Müller L. Clostridium difficile infection: guideline-based diagnosis and treatment. Dtsch Arztebl Int. 2014;111(43):723–31.

    PubMed  PubMed Central  Google Scholar 

  25. Luciano JA, Zuckerbraun BS. Clostridium difficile infection: prevention, treatment, and surgical management. Surg Clin North Am. 2014;94(6):1335–49.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Surgery, University Hospital, London Health Sciences Centre, London, ON, Canada

    Nawar A. Alkhamesi

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  1. Nawar A. Alkhamesi
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Correspondence to Nawar A. Alkhamesi .

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Editors and Affiliations

  1. London Health Sciences Centre, University Hospital, London, Ontario, Canada

    Christopher M. Schlachta

  2. Mount Sinai School of Medicine, New York, New York, USA

    Patricia Sylla

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Alkhamesi, N.A. (2018). Fulminant Clostridium difficile Colitis: Indications and Extent of Surgery. In: Schlachta, C., Sylla, P. (eds) Current Common Dilemmas in Colorectal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-70117-2_9

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  • DOI: https://doi.org/10.1007/978-3-319-70117-2_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-70116-5

  • Online ISBN: 978-3-319-70117-2

  • eBook Packages: MedicineMedicine (R0)

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