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Contact Dermatitis due to Irritation

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Kanerva’s Occupational Dermatology

Abstract

Irritant contact dermatitis (ICD) denotes inflammation of the skin which results from a contact with external agent and does not require prior sensitization of the immune system.

Irritant contact dermatitis is the most frequent cause for occupational contact dermatitis.

The clinical features are quite diverse and there are ten clinical types described: acute, acute delayed, irritant reaction, cumulative, traumiterative, exsiccation eczematid, traumatic, pustular and acneiform, nonerythematous, and subjective.

Distinction from allergic contact dermatitis (ACD) usually relies on time course (quicker onset in irritation), subjective symptoms (itch in ACD vs burning or pain in ICD), and morphology (spread outside the contact area, more infiltration and vesiculation in ACD). However, distinction may be clinically very difficult or impossible; histology, pathogenesis, and therapy are also very similar.

Atopic skin predisposition is the best established risk factor for irritant contact dermatitis; respiratory manifestations of atopy are less predictive than skin manifestations.

Prevention, early recognition, and therapy are decisive in averting chronic and persistent forms.

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References

  • Ale IS, Maibacht HA (2010) Diagnostic approach in allergic and irritant contact dermatitis. Expert Rev Clin Immunol 6(2):291–310

    Article  PubMed  Google Scholar 

  • Angelova-Fischer I (2016) Irritants and skin barrier function. Curr Probl Dermatol 49:80–89. https://doi.org/10.1159/000441547

    Article  PubMed  Google Scholar 

  • Arend WP, Guthridge CJ (2000) Biological role of interleukin 1 receptor antagonist isoforms. Ann Rheum Dis 59(Suppl 1):i60–i64

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Avnstorp C (1996) Irritant contact eczema. In: van der Valk PG, Maibach H (eds) The irritant contact dermatitis syndrome. CRC Press, Boca Raton, pp 111–119

    Google Scholar 

  • Bangha E, Hinnen U et al (1996) Irritancy testing in occupational dermatology: comparison between two quick tests and the acute irritation induced by sodium lauryl sulphate. Acta Derm Venereol 76(6):450–452

    CAS  PubMed  Google Scholar 

  • Bauer A, Schmitt J, Bennett C, Coenraads PJ, Elsner P, English J, Williams HC (2010) Interventions for preventing occupational irritant hand dermatitis. Cochrane Database Syst Rev 6:CD004414. https://doi.org/10.1002/14651858.CD004414.pub2

    Article  Google Scholar 

  • Belsito DV (2005) Occupational contact dermatitis: etiology, prevalence, and resultant impairment/disability. J Am Acad Dermatol 53(2):303–313

    Article  PubMed  Google Scholar 

  • Berardesca E, Distante F (1994) The modulation of skin irritation. Contact Dermatitis 31(5):281–287

    Article  CAS  PubMed  Google Scholar 

  • Berardesca E, Maibach HI (1988) Racial differences in sodium lauryl sulphate induced cutaneous irritation: black and white. Contact Dermatitis 18(2):65–70

    Article  CAS  PubMed  Google Scholar 

  • Berndt U, Hinnen U et al (1999) Is occupational irritant contact dermatitis predictable by cutaneous bioengineering methods? Results of the Swiss metalworkers’ eczema study (PROMETES). Dermatology 198(4):351–354

    Article  CAS  PubMed  Google Scholar 

  • Berndt U, Hinnen U et al (2000) Hand eczema in metalworker trainees–an analysis of risk factors. Contact Dermatitis 43(6):327–332

    Article  CAS  PubMed  Google Scholar 

  • Borlon C, Godard P et al (2007) The usefulness of toxicogenomics for predicting acute skin irritation on in vitro reconstructed human epidermis. Toxicology 241(3):157–166

    Article  CAS  PubMed  Google Scholar 

  • Brasch J, Burgard J et al (1992) Common pathogenetic pathways in allergic and irritant contact dermatitis. J Invest Dermatol 98(2):166–170

    Article  CAS  PubMed  Google Scholar 

  • Bryld LE, Hindsberger C et al (2003) Risk factors influencing the development of hand eczema in a population-based twin sample. Br J Dermatol 149(6):1214–1220

    Article  CAS  PubMed  Google Scholar 

  • Cahill J, Keegel T et al (2004) The prognosis of occupational contact dermatitis in 2004. Contact Dermatitis 51(5–6):219–226

    Article  PubMed  Google Scholar 

  • Chew AL, Maibach HI (2003) Occupational issues of irritant contact dermatitis. Int Arch Occup Environ Health 76(5):339–346

    Article  CAS  PubMed  Google Scholar 

  • Chew A-L, Maibach HI (2006) Ten genotypes of irritant contact dermatitis. In: Chew A-L, Maibach HI (eds) Irritant dermatitis. Springer, Berlin, pp 5–9

    Chapter  Google Scholar 

  • Clemmensen A, Andersen KE et al (2010) Genome-wide expression analysis of human in vivo irritated epidermis: differential profiles induced by sodium lauryl sulfate and nonanoic acid. J Invest Dermatol 130(9):2201–2210

    Article  CAS  PubMed  Google Scholar 

  • Coenraads PJ, Smit J (1995) Epidemiology. In: Rycroft RJG, Menne T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin, pp 133–150

    Google Scholar 

  • Corsini E, Galli CL (2000) Epidermal cytokines in experimental contact dermatitis. Toxicology 142(3):203–211

    Article  CAS  PubMed  Google Scholar 

  • Cronin E (1995) Hand eczema. In: Rycroft RJG, Menne T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin, pp 207–218

    Google Scholar 

  • de Jongh CM, Verberk MM et al (2006) Stratum corneum cytokines and skin irritation response to sodium lauryl sulfate. Contact Dermatitis 54(6):325–333

    Article  PubMed  Google Scholar 

  • de Jongh CM, Lutter R et al (2007) Differential cytokine expression in skin after single and repeated irritation by sodium lauryl sulphate. Exp Dermatol 16(12):1032–1040

    Article  PubMed  CAS  Google Scholar 

  • de Jongh CM, John SM et al (2008a) Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis. Contact Dermatitis 58(5):269–277

    Article  PubMed  Google Scholar 

  • de Jongh CM, Khrenova L et al (2008b) Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study. Br J Dermatol 159(3):621–627

    Article  PubMed  CAS  Google Scholar 

  • Dickel H, Kuss O et al (2001) Occupational skin diseases in Northern Bavaria between 1990 and 1999: a population-based study. Br J Dermatol 145(3):453–462

    Article  CAS  PubMed  Google Scholar 

  • Diepgen TL (2003) Occupational skin-disease data in Europe. Int Arch Occup Environ Health 76(5):331–338

    Article  PubMed  Google Scholar 

  • Diepgen TL, Coenraads PJ (1999) The epidemiology of occupational contact dermatitis. Int Arch Occup Environ Health 72(8):496–506

    Article  CAS  PubMed  Google Scholar 

  • Diepgen T, Coenraads PJ, Diepgen T, Coenraads PJ (1995) What can we learn from epidemiological studies on irritant contact dermatitis? In: Elsner P, Maibach H (eds) Irritant dermatitis: new clinical and experimental aspects. Karger, Basel, pp 18–27

    Google Scholar 

  • Diepgen T, Elsner P et al (2009a) Management von Handekzemen Leitlinie ICD-10-Ziffer: L20. L23. L24. L25. L30. J Dtsch Dermatol Ges 7(s3):s1–s16

    PubMed  Google Scholar 

  • Diepgen TL, Andersen KE et al (2009b) Hand eczema classification: a cross-sectional, multicentre study of the aetiology and morphology of hand eczema. Br J Dermatol 160(2):353–358

    Article  CAS  PubMed  Google Scholar 

  • Dika E, Branco N et al (2004) Immunologic patterns in allergic and irritant contact dermatitis: similarities. Exog Dermatol 3:113–120

    Article  Google Scholar 

  • Dooms-Goossens AE, Debusschere KM et al (1986) Contact dermatitis caused by airborne agents. A review and case reports. J Am Acad Dermatol 15(1):1–10

    Article  CAS  PubMed  Google Scholar 

  • Dursteler BB, Nyquist RA (2004) Outbreak of rove beetle (Staphylinid) pustular contact dermatitis in Pakistan among deployed U.S. personnel. Mil Med 169(1):57–60

    Article  PubMed  Google Scholar 

  • Eichmann A, Amgwerd D (1992) Toxic contact dermatitis. Schweiz Rundsch Med Prax 81(19):615–617

    CAS  PubMed  Google Scholar 

  • Elsner P (1994) Irritant dermatitis in the workplace. Dermatol Clin 12(3):461–467

    Article  CAS  PubMed  Google Scholar 

  • Elsner P, Baxmann F et al (1995) Metal working fluid dermatitis: a comparative follow-up study in patients with irritant and non-irritant hand dermatitis. In: Elsner P, Maibach H (eds) Irritant dermatitis: new clinical and experimental aspects. Karger, Basel, pp 77–88

    Google Scholar 

  • English J, Aldridge R et al (2009) Consensus statement on the management of chronic hand eczema. Clin Exp Dermatol 34(7):761–769

    Article  CAS  PubMed  Google Scholar 

  • Feingold KR, Schmuth M et al (2007) The regulation of permeability barrier homeostasis. J Invest Dermatol 127(7):1574–1576

    Article  CAS  PubMed  Google Scholar 

  • Fletcher ST, Baker VA et al (2001) Gene expression analysis of EpiDerm following exposure to SLS using cDNA microarrays. Toxicol In Vitro 15(4–5):393–398

    Article  CAS  PubMed  Google Scholar 

  • Fluhr JW, Kuss O et al (2001) Testing for irritation with a multifactorial approach: comparison of eight non-invasive measuring techniques on five different irritation types. Br J Dermatol 145(5):696–703

    Article  CAS  PubMed  Google Scholar 

  • Fluhr JW, Akengin A et al (2005) Additive impairment of the barrier function by mechanical irritation, occlusion and sodium lauryl sulphate in vivo. Br J Dermatol 153(1):125–131

    Article  CAS  PubMed  Google Scholar 

  • Fluhr JW, Darlenski R et al (2008) Skin irritation and sensitization: mechanisms and new approaches for risk assessment. 1. Skin irritation. Skin Pharmacol Physiol 21(3):124–135

    Article  CAS  PubMed  Google Scholar 

  • Freeman S, Maibach H (1988) Study of irritant contact dermatitis produced by repeat patch test with sodium lauryl sulfate and assessed by visual methods, transepidermal water loss, and laser Doppler velocimetry. J Am Acad Dermatol 19(3):496–502

    Article  CAS  PubMed  Google Scholar 

  • Frosch PJ (1995) Cutaneous irritation. In: Rycroft RJG, Menne T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin, pp 28–61

    Chapter  Google Scholar 

  • Frosch PJ, John SM (2006) Clinical aspects of irritant contact dermatitis. In: Frosch PJ, Menné T, Lepoittevin JP (eds) Contact dermatitis. Springer, Berlin, pp 255–294

    Chapter  Google Scholar 

  • Frosch PJ, John SM (2011) Clinical aspects of irritant contact dermatitis. In: Johansen JD, Frosch PJ, Lepoittevin JP (eds) Contact dermatitis. Springer, Berlin, pp 305–345

    Chapter  Google Scholar 

  • Frosch PJ, Kligman AM (1977) A method for appraising the stinging capacity of topically applied substances. J Soc Cosmet Chem 28:197–209

    Google Scholar 

  • Ghadially R, Brown BE et al (1995) The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 95(5):2281–2290

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gittler JK, Krueger JG, Guttman-Yassky E (2013) Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis. J Allergy Clin Immunol 131(2):300–313. https://doi.org/10.1016/j.jaci.2012.06.048

    Article  CAS  PubMed  Google Scholar 

  • Goh CL (1987) Occupational skin disease in Singapore: epidemiology & causative agents. Ann Acad Med Singap 16(2):303–305

    CAS  PubMed  Google Scholar 

  • Goh CL (1995) Noneczematous contact reactions. In: Rycroft RJG, Menne T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin, pp 221–236

    Google Scholar 

  • Goh CL (1997) Prognosis of contact and occupational dermatitis. Clin Dermatol 15(4):655–659

    Article  CAS  PubMed  Google Scholar 

  • Goldner R (1994) Work-related irritant contact dermatitis. Occup Med 9(1):37–44

    CAS  PubMed  Google Scholar 

  • Grangsjo A, Leijon-Kuligowski A et al (1996) Different pathways in irritant contact eczema? Early differences in the epidermal elemental content and expression of cytokines after application of 2 different irritants. Contact Dermatitis 35(6):355–360

    Article  CAS  PubMed  Google Scholar 

  • Hafner J, Ruegger M et al (1995) Airborne irritant contact dermatitis from metal dust adhering to semisynthetic working suits. Contact Dermatitis 32(5):285–288

    Article  CAS  PubMed  Google Scholar 

  • Hoefakker S, Caubo M et al (1995) In vivo cytokine profiles in allergic and irritant contact dermatitis. Contact Dermatitis 33(4):258–266

    Article  CAS  PubMed  Google Scholar 

  • Hogan DJ, Dannaker CJ et al (1990) The prognosis of contact dermatitis. J Am Acad Dermatol 23(2 Pt 1):300–307

    Article  CAS  PubMed  Google Scholar 

  • Holliday MR, Corsini E et al (1997) Differential induction of cutaneous TNF-alpha and IL-6 by topically applied chemicals. Am J Contact Dermatitis 8(3):158–164

    CAS  Google Scholar 

  • Holst R, Moller H (1975) One hundred twin pairs patch tested with primary irritants. Br J Dermatol 93(2):145–149

    Article  CAS  PubMed  Google Scholar 

  • Huang C, Liu Y et al (2009) An outbreak of 268 cases of Paederus dermatitis in a toy-building factory in central China. Int J Dermatol 48(2):128–131

    Article  PubMed  Google Scholar 

  • Hurwitz RM, Rivera HP et al (1984) Black-spot poison ivy dermatitis. An acute irritant contact dermatitis superimposed upon an allergic contact dermatitis. Am J Dermatopathol 6(4):319–322

    Article  CAS  PubMed  Google Scholar 

  • Itschner L, Hinnen U et al (1996) Prevention of hand eczema in the metal-working industry: risk awareness and behaviour of metal worker apprentices. Dermatology 193(3):226–229

    Article  CAS  PubMed  Google Scholar 

  • Kanerva L, Estlander T et al (1988) Occupational skin disease in Finland. An analysis of 10 years of statistics from an occupational dermatology clinic. Int Arch Occup Environ Health 60(2):89–94

    Article  CAS  PubMed  Google Scholar 

  • Kassis V, Vedel P et al (1984) Contact dermatitis to methyl methacrylate. Contact Dermatitis 11(1):26–28

    Article  CAS  PubMed  Google Scholar 

  • Keegel T, Moyle M et al (2009) The epidemiology of occupational contact dermatitis (1990–2007): a systematic review. Int J Dermatol 48(6):571–578

    Article  PubMed  Google Scholar 

  • Kezic S, Visser MJ, Verberk MM (2009) Individual susceptibility to occupational contact dermatitis. Ind Health 47(5):469–478

    Article  CAS  PubMed  Google Scholar 

  • Kupper TS (1990) Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations. J Clin Invest 86(6):1783–1789

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lachapelle JM (1995) Principles of prevention and protection in contact dermatitis (with special reference to occupational dermatology). In: Rycroft RJG, Menne T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin, pp 695–702

    Google Scholar 

  • Lachapelle JM (2006) Airborne irritant dermatitis. In: Chew AL, Maibach H (eds) Irritant dermatitis. Springer, Berlin, pp 71–79

    Chapter  Google Scholar 

  • Lammintausta K, Maibach HI (1990) Contact dermatitis due to irritation: general principles, etiology, and histology. In: Adams RM (ed) Occupational skin disease. W.B. Saunders, Philadelphia, pp 1–15

    Google Scholar 

  • Lammintausta K, Maibach HI et al (1988) Mechanisms of subjective (sensory) irritation. Propensity to non-immunologic contact urticaria and objective irritation in stingers. Derm Beruf Umwelt 36(2):45–49

    CAS  PubMed  Google Scholar 

  • Lee E, An S et al (2009) Development of a novel method for quantitative evaluation of sensory skin irritation inhibitors. Skin Res Technol 15(4):464–469

    Article  PubMed  Google Scholar 

  • Lee HY, Stieger M, Yawalkar N, Kakeda M (2013) Cytokines and chemokines in irritant contact dermatitis. Mediat Inflamm 2013:916497. https://doi.org/10.1155/2013/916497

    Article  CAS  Google Scholar 

  • Lerbaek A, Kyvik KO et al (2007) Heritability of hand eczema is not explained by comorbidity with atopic dermatitis. J Invest Dermatol 127(7):1632–1640

    Article  CAS  PubMed  Google Scholar 

  • Lofgren SM, Warshaw EM (2006) Dyshidrosis: epidemiology, clinical characteristics, and therapy. Dermatitis 17(4):165–181

    Article  PubMed  Google Scholar 

  • Lushniak BD (2003) The importance of occupational skin diseases in the United States. Int Arch Occup Environ Health 76(5):325–330

    Article  PubMed  Google Scholar 

  • Malten KE (1981) Thoughts on irritant contact dermatitis. Contact Dermatitis 7(5):238–247

    Article  CAS  PubMed  Google Scholar 

  • Malten KE, den Arend JA (1985) Irritant contact dermatitis. Traumiterative and cumulative impairment by cosmetics, climate, and other daily loads. Derm Beruf Umwelt 33(4):125–132

    CAS  PubMed  Google Scholar 

  • Malten KE, den Arend JA et al (1979) Delayed irritation: hexanediol diacrylate and butanediol diacrylate. Contact Dermatitis 5(3):178–184

    Article  CAS  PubMed  Google Scholar 

  • Marriott M, Holmes J et al (2005) The complex problem of sensitive skin. Contact Dermatitis 53(2):93–99

    Article  PubMed  Google Scholar 

  • Mathias CG (1990) Prevention of occupational contact dermatitis. J Am Acad Dermatol 23(4 Pt 1):742–748

    Article  CAS  PubMed  Google Scholar 

  • McDougal JN, Garrett CM et al (2007) Effects of brief cutaneous JP-8 jet fuel exposures on time course of gene expression in the epidermis. Toxicol Sci 95(2):495–510

    Article  CAS  PubMed  Google Scholar 

  • Meding B (2000) Differences between the sexes with regard to work-related skin disease. Contact Dermatitis 43(2):65–71

    Article  CAS  PubMed  Google Scholar 

  • Meding B, Swanbeck G (1990) Occupational hand eczema in an industrial city. Contact Dermatitis 22(1):13–23

    Article  CAS  PubMed  Google Scholar 

  • Molin S, Vollmer S et al (2009) Filaggrin mutations may confer susceptibility to chronic hand eczema characterized by combined allergic and irritant contact dermatitis. Br J Dermatol 161(4):801–807

    Article  CAS  PubMed  Google Scholar 

  • Moshell AN (1997) Workshop on irritant contact dermatitis. Am J Contact Dermatitis 8(2):79–105

    CAS  Google Scholar 

  • Mozzanica N (1992) Pathogenetic aspects of allergic and irritant contact dermatitis. Clin Dermatol 10(2):115–121

    Article  CAS  PubMed  Google Scholar 

  • Nakai K, Yoneda K, Kubota Y (2012) Oxidative stress in allergic and irritant dermatitis: from basic research to clinical management. Recent Patents Inflamm Allergy Drug Discov 6(3):202–209

    Article  CAS  Google Scholar 

  • Nicholson PJ (2011) Occupational contact dermatitis: known knowns and known unknowns. Clin Dermatol 29(3):325–330. https://doi.org/10.1016/j.clindermatol.2010.11.012

    Article  PubMed  Google Scholar 

  • Nilsson E (1986) Individual and environmental risk factors for hand eczema in hospital workers. Acta Derm Venereol Suppl (Stockh) 128:1–63

    CAS  Google Scholar 

  • Nosbaum A, Vocanson M, Rozieres A, Hennino A, Nicolas JF (2009) Allergic and irritant contact dermatitis. Eur J Dermatol: EJD 19(4):325–332. https://doi.org/10.1684/ejd.2009.0686

    Article  CAS  PubMed  Google Scholar 

  • Patil S, Maibach HI (1994) Effect of age and sex on the elicitation of irritant contact dermatitis. Contact Dermatitis 30(5):257–264

    Article  CAS  PubMed  Google Scholar 

  • Patiwael JA, Wintzen M et al (2005) Airborne irritant contact dermatitis due to synthetic fibres from an air-conditioning filter. Contact Dermatitis 52(3):126–129

    Article  CAS  PubMed  Google Scholar 

  • Pinnagoda J, Tupker RA et al (1989) The intra- and inter-individual variability and reliability of transepidermal water loss measurements. Contact Dermatitis 21(4):255–259

    Article  CAS  PubMed  Google Scholar 

  • Prakash AV, Davis MD (2010) Contact dermatitis in older adults: a review of the literature. Am J Clin Dermatol 11(6):373–381. https://doi.org/10.2165/11319290-000000000-00000

    Article  PubMed  Google Scholar 

  • Proksch E, Brandner JM et al (2008) The skin: an indispensable barrier. Exp Dermatol 17(12):1063–1072

    Article  PubMed  Google Scholar 

  • Rietschel RL (1997) Comparison of allergic and irritant dermatitis. Immunol Allergy Clin N Am 17:359–364

    Article  Google Scholar 

  • Robinson MK (2001) Intra-individual variations in acute and cumulative skin irritation responses. Contact Dermatitis 45(2):75–83

    Article  CAS  PubMed  Google Scholar 

  • Rogers JV, Garrett CM et al (2003) Gene expression in rat skin induced by irritating chemicals. J Biochem Mol Toxicol 17(3):123–137

    Article  CAS  PubMed  Google Scholar 

  • Rystedt I (1985) Work-related hand eczema in atopics. Contact Dermatitis 12(3):164–171

    Article  CAS  PubMed  Google Scholar 

  • Sajjachareonpong P, Cahill J et al (2004) Persistent post-occupational dermatitis. Contact Dermatitis 51(5–6):278–283

    Article  PubMed  Google Scholar 

  • Santos R, Goossens A (2007) An update on airborne contact dermatitis: 2001–2006. Contact Dermatitis 57(6):353–360

    Article  CAS  PubMed  Google Scholar 

  • Skogstad M, Levy F (1994) Occupational irritant contact dermatitis and fungal infection in construction workers. Contact Dermatitis 31(1):28–30

    Article  CAS  PubMed  Google Scholar 

  • Skudlik C, Weisshaar E et al (2009) Multicenter study “medical-occupational rehabilitation procedure skin – optimizing and quality assurance of inpatient-management (ROQ)”. J Dtsch Dermatol Ges 7(2):122–126

    PubMed  Google Scholar 

  • Spiekstra SW, Toebak MJ et al (2005) Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure. Exp Dermatol 14(2):109–116

    Article  CAS  PubMed  Google Scholar 

  • Spiewak R (2012) Contact dermatitis in atopic individuals. Curr Opin Allergy Clin Immunol 12(5):491–497. https://doi.org/10.1097/ACI.0b013e328357b05a

    Article  PubMed  Google Scholar 

  • Steciuk A, Dompmartin A et al (1997) Pustular contact dermatitis from fluorine in an antirust solution. Contact Dermatitis 36(5):276–277

    Article  CAS  PubMed  Google Scholar 

  • Suter-Widmer J, Elsner P (1996) Age and irritation. In: van der Valk PG, Maibach H (eds) The irritant contact dermatitis syndrome. CRC Press, Boca Raton, pp 257–261

    Google Scholar 

  • Tan CH, Rasool S, Johnston GA (2014) Contact dermatitis: allergic and irritant. Clin Dermatol 32(1):116–124. https://doi.org/10.1016/j.clindermatol.2013.05.033

    Article  PubMed  Google Scholar 

  • Thong H-Y, Maibach HI (2008) Irritant dermatitis as a model of inflammation. Drug Discov Today: Dis Mech 5(2):e221–e228

    Article  Google Scholar 

  • Thyssen JP, Johansen JD et al (2010a) The epidemiology of hand eczema in the general population–prevalence and main findings. Contact Dermatitis 62(2):75–87

    Article  PubMed  Google Scholar 

  • Thyssen JP, Linneberg A et al (2010b) The effect of tobacco smoking and alcohol consumption on the prevalence of self-reported hand eczema: a cross-sectional population-based study. Br J Dermatol 162(3):619–626

    Article  CAS  PubMed  Google Scholar 

  • van der Valk PG, Maibach HI (1989) Do topical corticosteroids modulate skin irritation in human beings? Assessment by transepidermal water loss and visual scoring. J Am Acad Dermatol 21(3 Pt 1):519–522

    Article  PubMed  Google Scholar 

  • van der Valk PG, Nater JP et al (1985) Vulnerability of the skin to surfactants in different groups of eczema patients and controls as measured by water vapour loss. Clin Exp Dermatol 10(2):98–103

    Article  PubMed  Google Scholar 

  • Wall LM, Gebauer KA (1991) A follow-up study of occupational skin disease in Western Australia. Contact Dermatitis 24(4):241–243

    Article  CAS  PubMed  Google Scholar 

  • Warner JA, Cruz PD Jr (2008) Grenz ray therapy in the new millennium: still a valid treatment option? Dermatitis 19(2):73–80

    Article  PubMed  Google Scholar 

  • Welss T, Basketter DA et al (2004) In vitro skin irritation: facts and future. State of the art review of mechanisms and models. Toxicol In Vitro 18(3):231–243

    Article  CAS  PubMed  Google Scholar 

  • Wigger-Alberti W, Elsner P (1997) Preventive measures in contact dermatitis. Clin Dermatol 15(4):661–665

    Article  CAS  PubMed  Google Scholar 

  • Wigger-Alberti W, Elsner P (1998) Do barrier creams and gloves prevent or provoke contact dermatitis? Am J Contact Dermatitis 9(2):100–106

    Article  CAS  Google Scholar 

  • Wigger-Alberti W, Hinnen U et al (1997) Predictive testing of metalworking fluids: a comparison of 2 cumulative human irritation models and correlation with epidemiological data. Contact Dermatitis 36(1):14–20

    Article  CAS  PubMed  Google Scholar 

  • Wilkinson JD, Willis CM (1998) Contact dermatitis: irritant. In: Champion RH, Burton JL, Burns DA, Breathnach SM (eds) Textbook of dermatology. Blackwell, London, pp 709–731

    Google Scholar 

  • Willis CM (1996) The histopathology of irritant contact dermatitis. In: van der Valk PGM, Maibach HI (eds) The irritant contact dermatitis syndrome. CRC Press, Boca Raton, pp 291–303

    Google Scholar 

  • Wolf R, Orion E, Ruocco E, Baroni A, Ruocco V (2013) Contact dermatitis: facts and controversies. Clin Dermatol 31(4):467–478. https://doi.org/10.1016/j.clindermatol.2013.01.014

    Article  PubMed  Google Scholar 

  • Wong R, Tran V et al (2004) Use of RT-PCR and DNA microarrays to characterize RNA recovered by non-invasive tape harvesting of normal and inflamed skin. J Invest Dermatol 123(1):159–167

    Article  CAS  PubMed  Google Scholar 

  • Wood BP, Greig DE (1997) Occupational dermatitis–what’s new? Catering industry. Clin Dermatol 15(4):567–571

    Article  CAS  PubMed  Google Scholar 

  • Wood LC, Elias PM et al (1996) Barrier disruption stimulates interleukin-1 alpha expression and release from a pre-formed pool in murine epidermis. J Invest Dermatol 106(3):397–403

    Article  CAS  PubMed  Google Scholar 

  • Zargari O, Kimyai-Asadi A et al (2003) Paederus dermatitis in northern Iran: a report of 156 cases. Int J Dermatol 42(8):608–612

    Article  PubMed  Google Scholar 

  • Zhai H, Maibach HI (2012) Anti-irritants agents for the treatment of irritant contact dermatitis: clinical and patent perspective. Recent Patents Inflamm Allergy Drug Discov 6(3):169–185

    Article  CAS  Google Scholar 

  • Zhai H, Meier-Davis SR, Cayme B, Shudo J, Maibach H (2012) Irritant contact dermatitis: effect of age. Cutan Ocul Toxicol 31(2):138–143. https://doi.org/10.3109/15569527.2011.618472

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, University Hospital Jena, Jena, Germany

    Dimitar Antonov & Peter Elsner

  2. Department of Dermatology, University Hospital Jena, Friedrich-Schiller-University, Jena, Germany

    Sibylle Schliemann

Authors
  1. Dimitar Antonov
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  2. Sibylle Schliemann
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  3. Peter Elsner
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Corresponding author

Correspondence to Peter Elsner .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany

    Swen Malte John

  2. National Allergy Research Centre, Department of Dermatology and Allergy, Herlev-Gentofte University Hospital, Hellerup, Hellerup, Denmark

    Jeanne Duus Johansen

  3. Department of Dermatology and Allergology, VU University Medical Center, Amsterdam, The Netherlands

    Thomas Rustemeyer

  4. Department of Dermatology, University Hospital Jena, Jena, Germany

    Peter Elsner

  5. Department of Dermatology, University of California, San Francisco, CA, USA

    Howard I. Maibach

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Antonov, D., Schliemann, S., Elsner, P. (2020). Contact Dermatitis due to Irritation. In: John, S., Johansen, J., Rustemeyer, T., Elsner, P., Maibach, H. (eds) Kanerva’s Occupational Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-68617-2_12

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  • DOI: https://doi.org/10.1007/978-3-319-68617-2_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-68615-8

  • Online ISBN: 978-3-319-68617-2

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