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Radionanomedicine pp 153–165Cite as

Endogenous Radionanomedicine: Biodistribution and Imaging

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Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

In vivo distribution of extracellular vesicles (EVs) are important in clinical application. Recently, tracking methods have been developed to monitor EVs in vivo. It ranged from fluorescence imaging to clinically available radionuclide imaging or magnetic resonance imaging. Each method has pros and cons in terms of capability of quantification, penetration depth, availability and clinical translatability. We introduce currently available labeling methods for imaging and their advantages and disadvantages. These imaging methods have elucidated the in vivo biodistribution of EVs. However, technical factors such as isolation, labeling methods and administration methods as well as biological factors including cell sources have resulted in variability of biodistribution patterns. We also review biodistribution results of EVs and what impacts on biodistribution.

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea

    Hongyoon Choi & Dong Soo Lee

  2. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Medicine or College of Pharmacy, Seoul National University, Seoul, 03080, Republic of Korea

    Hongyoon Choi & Dong Soo Lee

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  1. Hongyoon Choi
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  2. Dong Soo Lee
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Correspondence to Hongyoon Choi .

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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Choi, H., Lee, D.S. (2018). Endogenous Radionanomedicine: Biodistribution and Imaging. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_8

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