Skip to main content

One-Step TMLE

  • Chapter
  • First Online:
Targeted Learning in Data Science

Part of the book series: Springer Series in Statistics ((SSS))

Abstract

In this chapter, we will present one-dimensional universal least favorable parametric submodels for the TMLE of univariate and multivariate target parameters. They guarantee that a single TMLE-update of the initial estimator already solves the efficient influence curve equation. We explain why this type of one-step TMLE is more stable than an iterative TMLE. By the fact that the one-step TMLE for high-dimensional or even infinite-dimensional target parameters is a substitution estimator, it follows that it completely respects the structure of the infinite dimensional parameter. The content of this chapter partly relies on vanĀ der Laan and GruberĀ (2016). As an example, we present a one-step TMLE of a complete treatment-specific survival function.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • K.L. Moore, M.J. vanĀ der Laan, Application of time-to-event methods in the assessment of safety in clinical trials, in Design, Summarization, Analysis & Interpretation of Clinical Trials with Time-to-Event Endpoints, ed. by K.E. Peace (Chapman & Hall, Boca Raton, 2009a)

    Google ScholarĀ 

  • K.L. Moore, M.J. vanĀ der Laan, Covariate adjustment in randomized trials with binary outcomes: targeted maximum likelihood estimation. Stat. Med. 28(1), 39ā€“64 (2009b)

    Google ScholarĀ 

  • K.L. Moore, M.J. vanĀ der Laan, Increasing power in randomized trials with right censored outcomes through covariate adjustment. J. Biopharm. Stat. 19(6), 1099ā€“1131 (2009c)

    Google ScholarĀ 

  • M.J. vanĀ der Laan, S.Ā Gruber, One-step targeted minimum loss-based estimation based on universal least favorable one-dimensional submodels. Int. J. Biostat. 12(1), 351ā€“378 (2016)

    MathSciNetĀ  Google ScholarĀ 

  • M.J. vanĀ der Laan, M.Ā Petersen, W.Ā Zheng, Estimating the effect of a community-based intervention with two communities. J. Causal Inference 1(1), 83ā€“106 (2013b)

    Google ScholarĀ 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark J. van der Laan .

Rights and permissions

Reprints and permissions

Copyright information

Ā© 2018 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

van der Laan, M.J., Cai, W., Gruber, S. (2018). One-Step TMLE. In: Targeted Learning in Data Science. Springer Series in Statistics. Springer, Cham. https://doi.org/10.1007/978-3-319-65304-4_5

Download citation

Publish with us

Policies and ethics