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Approach to the Elderly Patient with Delirium: Geriatrician’s Perspective

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Abstract

Delirium, a geriatric syndrome, is a complex clinical condition defined as an acute, fluctuating syndrome of altered attention, awareness, and cognition. Although delirium is common in the elderly, it can be easily unrecognized. The consequences could be significant such as an increase in mortality, hospitalization, loss of autonomy, and increased risk to be institutionalized. The predisposing and precipitating factors are well known, but the pathogenesis is not yet identified clearly. In the geriatric practice, delirium is associated with serious complications, but can also be treatable if diagnosed early and managed properly. It is important to health-care professionals to perform preventative strategies for patients at high risk and be aware of the potential for each single older adult to develop delirium, at the beginning. For these purpose, ensuring adequate vision, hearing, nutrition, hydration, and sleep, informing the caregivers about delirium for recognizing early symptoms of delirium, mobilizing the patient as early as possible, and managing the pain are strongly recommended. In addition, clinicians must identify the real underlying medical conditions at the same time. If non-pharmacologic interventions are insufficient, pharmacologic intervention should not be implemented.

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References

  • Al-Aama T, Brymer C, Gutmanis I et al (2011) Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. Int J Geriatr Psychiatry 26:687–694

    Article  Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and statistical manual, 5th edn. APA Press, Washington, DC

    Google Scholar 

  • Ansaloni L, Catena F, Chattat R et al (2010) Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery. Br J Surg 97(2):273–280

    Article  CAS  Google Scholar 

  • Bucht G, Gustafson Y, Sandberg O (1999) Epidemiology of delirium. Dement Geriatr Cogn Disord 10:315–318

    Article  CAS  Google Scholar 

  • Brannstron B, Gustafson Y, Norberg A, Winblad B (1998) ADL performance and dependency on nursing care in patients with hip fractures and acute confusion in a task allocation care system. Scand J Caring Sci 5:3–11

    Article  Google Scholar 

  • Caraceni A, Grassi L (2011) Deliriumacute confusional states in palliative medicine, 2nd edn. Oxford University Press, Oxford

    Google Scholar 

  • Davis HJ, Muniz-Terrera G, Keage HAD et al (2017) Association of delirium with cognitive decline in late life: a neuropathologic study of 3 population-based cohort studies. JAMA Psychiat 74:244–251

    Article  Google Scholar 

  • Devlin JW, Al-Qadhee NS, Skrobik Y (2012) Pharmacologic prevention and treatment of delirium in critically ill and non-critically ill hospitalised patients: a review of data from prospective, randomised studies. Best Pract Res Clin Anaesthesiol 26:289

    Article  CAS  Google Scholar 

  • Ely EW, Inouye SK, Bernard GR et al (2001) Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 286:2703

    Article  CAS  Google Scholar 

  • Fong TG, Tulebaev SR, Inouye SK (2009) Delirium in elderly adults: diagnosis, prevention and treatment. Nat Rev Neurol 5:210–220

    Article  Google Scholar 

  • Gross AL, Jones RN, Habtemariam DA et al (2012) Delirium and long-term cognitive trajectory among persons with dementia. Arch Intern Med 172:1324–1331

    Article  Google Scholar 

  • Han JH, Zimmerman EE, Cutler N et al (2009) Delirium in older emergency department patients: recognition, risk factors, and psychomotor subtypes. Acad Emerg Med 16:193–200

    Article  Google Scholar 

  • Hatta K, Kishi Y, Wada K et al (2014) Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial. JAMA Psychiat 71(4):397–403

    Article  CAS  Google Scholar 

  • Hempenius L, van Leeuwen BL, van Asselt DZ et al (2011) Structured analyses of interventions to prevent delirium. Int J Geriatr Psychiatry 26:441–450

    Article  Google Scholar 

  • Hoffmann M, Schneider D (2007) Practice guidelines for the treatment of patients with delirium. In: Skolnik NS (ed) Essential practice guidelines in primary care current clinical practice. Humana Press, Totowa, NJ, pp 341–349

    Chapter  Google Scholar 

  • Inouye SK, Bogardus ST Jr, Charpentier PA et al (1999) A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 340:669–676

    Article  CAS  Google Scholar 

  • Inouye SK, Charpentier PA (1996) Precipitating factors for Delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA 275:852–857

    Article  CAS  Google Scholar 

  • Inouye SK (1998) Delirium in hospitalized older patients. Clin Geriatr Med 14(4):745–765

    Article  CAS  Google Scholar 

  • Inouye SK (2006) Delirium in older adults. N Engl J Med 354:1157–1165

    Article  CAS  Google Scholar 

  • Inouye SK, van Dyck CH, Alessi CA et al (1990) Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med 113:941–948

    Article  CAS  Google Scholar 

  • Inouye SK, Viscoli CM, Horwitz RI et al (1993) A predictive model for Delirium in hospitalized elderly medical patients based on admission characteristics. Ann Intern Med 119:474–481

    Article  CAS  Google Scholar 

  • Inouye SK, Westendorp RG, Saczynski JS (2014) Delirium in elderly people. Lancet 383:911–922

    Article  Google Scholar 

  • Isik AT (2014) Geriatrik Olgularda Deliryum/Delirium in The Elderly. İzmir Guven Kitap, Turkey, Izmir. ISBN: 978-605-60355

    Google Scholar 

  • Han JH, Vasilevskis EE, Chandrasekhar R et al (2017) Delirium in the Emergency Department and Its Extension into Hospitalization (DELINEATE) study: effect on 6-month function and cognition. J Am Geriatr Soc 65(6):1333–1338

    Article  Google Scholar 

  • Kalish VB, Gillham JE, Unwin BK (2014) Delirium in older persons: evaluation and management. Am Fam Physician 90(3):150–158

    PubMed  Google Scholar 

  • Kennedy GJ (2003) Dementia. In: Cassel CK, Leipzig RM, Cohen HJ, Larson EB, Meier DE (eds) Geriatric medicine: an evidence based approach, 4th edn. Springer, New York, pp 1079–1093

    Chapter  Google Scholar 

  • Larsen KA, Kelly SE, Stern TA et al (2010) Administration of olanzapine to prevent postoperative delirium in elderly joint-replacement patients: a randomized, controlled trial. Psychosomatics 51(5):409–418

    Article  CAS  Google Scholar 

  • Leung JM, Sands LP, Rico M et al (2006) Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients. Neurology 67(7):1251–1253

    Article  CAS  Google Scholar 

  • Maldonado JR (2008) Delirium in the acute care setting: characteristics, diagnosis and treatment. Crit Care Clin 24(4):657–722

    Article  CAS  Google Scholar 

  • Morandi A, Davis D, Fick DM et al (2014) Delirium superimposed on dementia strongly predicts worse outcomes in older rehabilitation inpatients. JAMA 15:349–354

    Google Scholar 

  • Pandharipande PP, Pun BT, Herr DL et al (2007) Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 298(22):2644–2653

    Article  CAS  Google Scholar 

  • Rana AQ, Morren JA (2013) Delirium, neurological emergencies in clinical practice. Springer, London, pp 15–23

    Book  Google Scholar 

  • Richardson SJ, Davis DHJ, Bellelli G et al (2017) Detecting delirium superimposed on dementia: diagnostic accuracy of a simple combined arousal and attention testing procedure. Int Psychogeriatr 31:1–9

    Google Scholar 

  • Saxena S, Lawley D (2009) Delirium in the elderly: a clinical review. Postgrad Med J 85(1006):405–413

    Article  CAS  Google Scholar 

  • Schweickert WD, Pohlman MC, Pohlman AS et al (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373(9678):1874–1882

    Article  Google Scholar 

  • Shehabi Y, Grant P, Wolfenden H et al (2009) Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM study). Anesthesiology 111(5):1075–1084

    Article  CAS  Google Scholar 

  • Siddiqi N, House AO, Holmes JD (2006) Occurrence and outcome of delirium in medical in-patients: a systematic literature review. Age Ageing 35:350–364

    Article  Google Scholar 

  • Soysal P, Kaya D, Isik AT (2015) Current concepts in the diagnosis, pathophysiology, and treatment of delirium: a European perspective. Curr Geri Rep 4:284–289

    Article  Google Scholar 

  • Sultan SS (2010) Assessment of role of perioperative melatonin in prevention and treatment of postoperative delirium after hip arthroplasty under spinal anesthesia in the elderly. Saudi J Anaesth 4:169–173

    Article  Google Scholar 

  • Tomlinson EJ, Phillips NM, Mohebbi M, Hutchinson AM (2017) Risk factors for incident delirium in an acute general medical setting: a retrospective case-control study. J Clin Nurs 26(5–6):658–667

    Article  Google Scholar 

  • Van Rompaey B, Elseviers MM, Van Drom W et al (2012) The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients. Crit Care 16:R73

    Article  Google Scholar 

  • Vardi K, Harrington CJ (2014) Delirium: treatment and prevention (part 2). R I Med J 97(6):24–28

    Google Scholar 

  • Williams-Russo P, Urquhart BL, Sharrock NE, Charlson ME (1992) Postoperative delirium: predictors and prognosis in elderly orthopedic patients. J Am Geriatr Soc 40:759–767

    Article  CAS  Google Scholar 

  • Yoon HJ, Park KM, Choi WJ et al (2013) Efficacy and safety of haloperidol versus atypical antipsychotic medications in the treatment of delirium. BMC Psychiatry 13:240

    Article  Google Scholar 

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Correspondence to Ahmet Turan Isik M.D. .

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Bulut, E.A., Isik, A.T. (2018). Approach to the Elderly Patient with Delirium: Geriatrician’s Perspective. In: Isik, A., Grossberg, G. (eds) Delirium in Elderly Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-65239-9_5

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  • DOI: https://doi.org/10.1007/978-3-319-65239-9_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-65237-5

  • Online ISBN: 978-3-319-65239-9

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