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The Patient with Severe Co-morbidities: Cardiac Disease

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Liver Anesthesiology and Critical Care Medicine

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References

  1. Fouad TR, Abdel-Razek WM, Burak KW, Bain VG, Lee SS. Prediction of cardiac complications after liver transplantation. Transplantation. 2009;87:763–70.

    Article  PubMed  Google Scholar 

  2. VanWagner LB, Lapin B, Levitsky J, Wilkins JT, Abecassis MM, Skaro AI, et al. High early cardiovascular mortality after liver transplantation. Liver Transpl. 2014;20:1306–16.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Shaw BW Jr, Bahnson HT, Hardesty RL, Griffith BP, Starzl TE. Combined transplantation of the heart and liver. Ann Surg. 1985;202:667–72.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Møller S, Henriksen JH. Cardiopulmonary complications in chronic liver disease. World J Gastroenterol. 2006;12:526–38.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Schrier RW, Arroyo V, Bernardi M, Henriksen JH, Rodes J. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology. 1988;8:1151–7.

    Article  CAS  PubMed  Google Scholar 

  6. Ma Z, Lee SS. Cirrhotic cardiomyopathy: getting to the heart of the matter. Hepatology. 1996;24:451–9.

    Article  CAS  PubMed  Google Scholar 

  7. Henriksen JH, Møller S. Cardiac and systemic hemodynamic complications of liver cirrhosis. Scand Cardiovasc J. 2009;43:218–25.

    Article  CAS  PubMed  Google Scholar 

  8. Dowsley TF, Bayne DB, Langnas AN, Dumitru I, Windle JR, Porter TR, et al. Diastolic dysfunction in patients with end-stage liver disease is associated with development of heart failure early after liver transplantation affecting survival. Transplantation. 2012;94:646–51.

    Article  PubMed  Google Scholar 

  9. Howell WL, Manion WC. The low incidence of myocardial infarction in patients with portal cirrhosis of the liver: a review of 639 cases of cirrhosis of the liver from 17,731 autopsies. Am Heart J. 1960;60:341–4.

    Article  CAS  PubMed  Google Scholar 

  10. Kalaitzakis E, Rosengren A, Skommevik T, Björnsson E. Coronary artery disease in patients with liver cirrhosis. Dig Dis Sci. 2010;55:467–75.

    Article  PubMed  Google Scholar 

  11. Ehtisham J, Altieri M, Salamé E, Saloux E, Ollivier I, Hamon M. Coronary artery disease in orthotopic liver transplantation: pretransplant assessment and management. Liver Transpl. 2010;16:550–7.

    PubMed  Google Scholar 

  12. Burke A, Lucey MR. Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation. Am J Tranplant. 2004;4:686–93.

    Article  Google Scholar 

  13. Zetterman RK, Belle SH, Hoofnagle JH, Lawlor S, Wei Y, Everhart J, et al. Age and liver transplantation: a report of the Liver Transplantation Database. Transplantation. 1998;66:500–6.

    Article  CAS  PubMed  Google Scholar 

  14. Kalaitzakis E, Björnsson E. Coronary artery disease in liver cirrhosis: does the aetiology of liver disease matter? J Hepatol. 2009;51:962–3.

    Article  PubMed  Google Scholar 

  15. Murray RP, Connett JE, Tyas SL, Bond R, Ekuma O, Silversides CK, et al. Alcohol volume, drinking pattern, and cardiovascular disease morbidity and mortality: is there a U-shaped function? Am J Epidemiol. 2002;155:242–8.

    Article  PubMed  Google Scholar 

  16. Berzigotti A, Bonfiglioli A, Muscari A, Bianchi G, LiBassi S, Bernardi M, et al. Reduced prevalence of ischemic events and abnormal supraortic flow patterns in patients with liver cirrhosis. Liver Int. 2005;25:331–6.

    Article  PubMed  Google Scholar 

  17. Kadayifci A, Tan V, Ursell PC, Merriman RB, Bass NM. Clinical and pathologic risk factors for atherosclerosis in cirrhosis: a comparison between NASH-related cirrhosis and cirrhosis due to other aetiologies. J Hepatol. 2008;49:595–9.

    Article  PubMed  Google Scholar 

  18. Donovan CL, Marcovitz PA, Punch JD, Bach DS, Brown KA, Lucey MR, et al. Two-dimensional and dobutamine stress echocardiography in the preoperative assessment of patients with end-stage liver disease prior to orthotopic liver transplantation. Transplantation. 1996;61:1180–8.

    Article  CAS  PubMed  Google Scholar 

  19. Plotkin JS, Benitez M, Kuo PC, Njoku MJ, Ridge LA, Lim JW, et al. Dobutamine stress echocardiography for preoperative cardiac risk stratification in patients undergoing orthotopic liver transplantation. Liver Transpl Surg. 1998;4:253–7.

    Article  CAS  PubMed  Google Scholar 

  20. Tiukinhoy-Laing SD, Rossi JS, Bayram M, De Luca L, Gafoor S, Blei A, et al. Cardiac hemodynamic and coronary angiographic characteristics of patients being evaluated for liver transplantation. Am J Cardiol. 2006;98:178–81.

    Article  PubMed  Google Scholar 

  21. Carey WD, Dumot JA, Pimentel RR, Barnes DS, Hobbs RE, Henderson JM, et al. The prevalence of coronary artery disease in liver transplant candidates over age 50. Transplantation. 1995;27:859–64.

    Article  Google Scholar 

  22. Plotkin JS, Scott VL, Pinna A, Dobsch BP, De Wolf AM, Kang Y. Morbidity and mortality in patients with coronary artery disease undergoing orthtotopic liver transplantation. Liver Transpl Surg. 1996;2:426–30.

    Article  CAS  PubMed  Google Scholar 

  23. Diedrich DA, Findlay JY, Harrison BA, Rosen CB. Influence of coronary artery disease on outcomes after liver transplantation. Transplant Proc. 2008;40:3554–7.

    Article  CAS  PubMed  Google Scholar 

  24. Johnston SD, Morris JK, Cramb R, Gunson BK, Neuberger J. Cardiovascular morbidity and mortality after orthotopic liver transplantation. Transplantation. 2002;73:901–6.

    Article  PubMed  Google Scholar 

  25. Wray C, Scovotti JC, Tobis J, Niemann CU, Planinsic R, Walia A, et al. Liver transplantation outcome in patients with angiographically proven coronary artery disease: a multi-institutional study. Am J Transplant. 2013;13:184–91.

    Article  CAS  PubMed  Google Scholar 

  26. Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL, Fleischmann KE, et al. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery. J Am Coll Cardiol. 2007;50:1707–32.

    Article  PubMed  Google Scholar 

  27. Cholongitas E, Senzolo M, Patch D, Shaw S, O’Beirne J, Burroughs AK. Cirrhotics admitted to intensive care unit: the impact of acute renal failure on mortality. Eur J Gastroenterol Hepatol. 2009;21:744–50.

    Article  PubMed  Google Scholar 

  28. Lester SJ, Hurst RT. Liver transplantation: do you have the heart for it? Liver Transpl. 2006;12:520–2.

    Article  PubMed  Google Scholar 

  29. Sharma M, Yong C, Majure D, Zellner C, Roberts JP, Bass NM, et al. Safety of cardiac catheterization in patients with end-stage liver disease awaiting liver transplantation. Am J Cardiol. 2009;103:742–6.

    Article  PubMed  Google Scholar 

  30. Findlay JY, Keegan MT, Pellikka PP, Rosen CB, Plevak DJ. Preoperative dobutamine stress echocardiography, intraoperative events, and intraoperative myocardial injury in liver transplantation. Transplant Proc. 2005;37:2209–13.

    Article  CAS  PubMed  Google Scholar 

  31. Umphrey LG, Hurst RT, Eleid MF, Lee KS, Reuss CS, Hentz JG, et al. Preoperative dobutamine stress echocardiographic findings and subsequent short-term adverse cardiac events after orthotopic liver transplantation. Liver Transpl. 2008;14:886–92.

    Article  PubMed  Google Scholar 

  32. Safadi A, Homsi M, Maskoun W, Lane KA, Singh I, Sawada SG, et al. Perioperative risk predictors of cardiac outcomes in patients undergoing liver transplantation surgery. Circulation. 2009;120:1189–94.

    Article  PubMed  Google Scholar 

  33. Williams K, Lewis JF, Davis G, Geiser EA. Dobutamine stress echocardiography in patients undergoing liver transplantation evaluation. Transplantation. 2000;69:2354–6.

    Article  CAS  PubMed  Google Scholar 

  34. Harinstein ME, Flaherty JD, Ansari AH, Robin J, Davidson CJ, Rossi JS, et al. Predictive value of dobutamine stress echocardiography for coronary artery disease detection in liver transplant candidates. Am J Transplant. 2008;8:1523–8.

    Article  CAS  PubMed  Google Scholar 

  35. Tsutsui J, Mukherjee S, Elhendy A, Xie F, Lyden ER, O’Leary EO, et al. Value of dobutamine stress myocardial contrast perfusion echocardiography in patients with advanced liver disease. Liver Transpl. 2006;12:592–9.

    Article  PubMed  Google Scholar 

  36. Abraczinskas DR, Ookubo R, Grace ND, Groszmann RJ, Bosch J, Garcia-Tsao G, et al. Propranolol for the prevention of first esophageal variceal hemorrhage: a lifetime commitment? Hepatology. 2001;34:1096–102.

    Article  CAS  PubMed  Google Scholar 

  37. Berman DS, Abidov A, Kang X, Hayes SW, Friedman JD, Sciammarella MG, et al. Prognostic validation of a 17-segment score derived from a 20-segment score for myocardial perfusion SPECT interpretation. J Nucl Cardiol. 2004;11:414–23.

    Article  PubMed  Google Scholar 

  38. Kryzhanovski VA, Beller GA. Usefulness of preoperative noninvasive radionuclide testing for detecting coronary artery disease in candidates for liver transplantation. Am J Cardiol. 1997;79:986–8.

    Article  CAS  PubMed  Google Scholar 

  39. Davidson CJ, Gheorghiade M, Flaherty JD, Elliott MD, Reddy SP, Wang NC, et al. Predictive value of stress myocardial perfusion imaging in liver transplant candidates. Am J Cardiol. 2002;89:359–60.

    Article  PubMed  Google Scholar 

  40. Zoghbi GJ, Patel AD, Ershadi RE, Heo J, Bynon JS, Iskandrian AE. Usefulness of preoperative stress perfusion imaging in predicting prognosis after liver transplantation. Am J Cardiol. 2003;92:1066–71.

    Article  PubMed  Google Scholar 

  41. Aydinalp A, Bal U, Atar I, Ertan C, Aktas A, Yildirir A, et al. Value of stress myocardial perfusion scanning in diagnosis of severe coronary artery disease in liver transplantation candidates. Transplant Proc. 2009;41:3757–60.

    Article  CAS  PubMed  Google Scholar 

  42. Senzolo M, Bassanello M, Graziotto A, Zucchetta P, Cillo U, Maraglino G, et al. Microvascular autonomic dysfunction may justify false-positive stress myocardial perfusion imaging in patients with liver cirrhosis undergoing liver transplantation. Transplant Proc. 2008;40:1916–7.

    Article  CAS  PubMed  Google Scholar 

  43. Lanza GA, Crea P. Primary coronary microvascular dysfunction. Clinical presentation, pathophysiology, and management. Circulation. 2010;121:2317–25.

    Article  PubMed  Google Scholar 

  44. Guckelberger O, Byram A, Klupp J, Neumann UP, Glanemann M, Stockmann M, et al. Coronary event rates in liver transplant recipients reflect the increased prevalence of cardiovascular risk factors. Transpl Int. 2005;18:967–74.

    Article  PubMed  Google Scholar 

  45. Assy N, Djibre A, Farah R, Grosovski M, Marmor A. Presence of coronary plaques in patients with nonalcoholic fatty liver disease. Radiology. 2010;254:393–400.

    Article  PubMed  Google Scholar 

  46. McAvoy NC, Kochar N, McKillop G, Newby DE, Hayes PC. Prevalence of coronary artery calcification in patients undergoing assessment for orthotopic liver transplantation. Liver Transpl. 2008;14:1725–31.

    Article  PubMed  Google Scholar 

  47. Plotkin JS, Johnson LB, Rustgi V, Kuo PC. CAD and liver transplantation: the state of the art. Liver Transpl. 2000;6:S53–6.

    Article  CAS  PubMed  Google Scholar 

  48. Warnaar N, Lisman T, Porte RJ. The two tales of coagulation in liver transplantation. Curr Opin Organ Transplant. 2008;13:298–303.

    Article  PubMed  Google Scholar 

  49. Lisman T, Bongers TN, Adelmeijer J, Janssen HL, de Maat MP, de Groot PG, et al. Elevated levels of von Willebrand factor in cirrhosis support platelet adhesion despite reduced functional capacity. Hepatology. 2006;44:53–61.

    Article  CAS  PubMed  Google Scholar 

  50. Kaplan M, Cimen S, Kut MS, Demirtas MM. Cardiac operations for patients with chronic liver disease. Heart Surg Forum. 2002;5:60–5.

    PubMed  Google Scholar 

  51. Hayashida N, Shoujima T, Teshima H, Yokokura Y, Takagi K, Tomoeda H, et al. Clinical outcome after cardiac operations in patients with cirrhosis. Ann Thorac Surg. 2004;77:500–5.

    Article  PubMed  Google Scholar 

  52. Filsoufi F, Salzberg SP, Rahmanian PB, Schiano TD, Elsiesy H, Squire A, et al. Early and late outcome of cardiac surgery in patients with liver cirrhosis. Liver Transpl. 2007;13:990–5.

    Article  PubMed  Google Scholar 

  53. Klemperer JD, Ko W, Krieger KH, Connolly M, Rosengart TK, Altorki NK, et al. Cardiac operations in patients with cirrhosis. Ann Thorac Surg. 1998;65:85–7.

    Article  CAS  PubMed  Google Scholar 

  54. An Y, Xiao YB, Zhong QJ. Open-heart surgery in patients with liver cirrhosis. Eur J Cardiothorac Surg. 2007;31:1094–8.

    Article  PubMed  Google Scholar 

  55. Bizouarn P, Ausseur A, Desseigne P, Le Teurnier Y, Nougarede B, Train M, et al. Early and late outcome after elective cardiac surgery in patients with cirrhosis. Ann Thorac Surg. 1999;67:1334–8.

    Article  CAS  PubMed  Google Scholar 

  56. Axelrod D, Koffron A, DeWolf A, Baker A, Fryer J, Baker T, et al. Safety and efficacy of combined orthotopic liver transplantation and coronary artery bypass grafting. Liver Transpl. 2004;10:1386–90.

    Article  PubMed  Google Scholar 

  57. Carr C, Desai J. OPCAB surgery in a cirrhotic hepatocellular carcinoma patient awaiting liver transplant. Ann Thorac Surg. 2004;78:1460–2.

    Article  PubMed  Google Scholar 

  58. Ben Ari A, Elinav E, Elami A, Matot I. Off-pump coronary artery bypass grafting in a patient with Child class C liver cirrhosis awaiting liver transplantation. Br J Anaesth. 2006;97:468–72.

    Article  CAS  PubMed  Google Scholar 

  59. Shaheen AA, Kaplan GG, Hubbard JN, Myers RP. Morbidity and mortality following coronary artery bypass graft surgery in patients with cirrhosis: a population-based study. Liver Int. 2009;29:1141–51.

    Article  PubMed  Google Scholar 

  60. Alper I, Ulukaya S, Demir F, Kilic M. Effects of cardiac valve dysfunction on perioperative management of liver transplantation. Transplant Proc. 2009;41:1722–6.

    Article  CAS  PubMed  Google Scholar 

  61. Pocar M, Passolunghi D, Moneta A, Donatelli F. Primary and redo valve replacement before and after liver transplantation. Eur J Cardiothorac Surg. 2007;32:674–5.

    Article  PubMed  Google Scholar 

  62. Iino K, Tomita S, Yamaguchi S, Watanabe G. Successful aortic valve replacement using dilutional ultrafiltration during cardiopulmonary bypass in a patient with Child-Pugh class C cirrhosis. Interact Cardiovasc Thorac Surg. 2008;7:331–2.

    Article  PubMed  Google Scholar 

  63. Kalarickal P, Liu Q, Rathor R, Ishag S, Kerr T, Kangrga I. Balloon aortic valvuloplasty as a bridge to liver transplantation in patients with severe aortic stenosis: a case series. Transplant Proc. 2014;46:3492–5.

    Article  CAS  PubMed  Google Scholar 

  64. Eckhoff DE, Frenette L, Sellers MT, McGuire BM, Contreras JL, Bynon JS, et al. Combined cardiac surgery and liver transplantation. Liver Transpl. 2001;7:60–1.

    Article  CAS  PubMed  Google Scholar 

  65. Kia L, Shah SJ, Wang E, Sharma D, Selvaraj S, Medina C, et al. Role of pretransplant echocardiographic evaluation in predicting outcomes following liver transplantation. Am J Transplant. 2013;13:2395–401.

    Article  CAS  PubMed  Google Scholar 

  66. Bargehr J, Trejo-Gutierrez JF, Patel T, Rosser B, Aranda-Michel J, Yataco ML, et al. Preexisting atrial fibrillation and cardiac complications after liver transplantation. Liver Transpl. 2015;21:314–20.

    Article  PubMed  Google Scholar 

  67. Van Wagner LB, Serper M, Kang R, Levitsky J, Hohmann S, Abecassis M, et al. Factors associated with major adverse cardiovascular events after liver transplantation among a national sample. Am J Transplant. 2016;16(9):2684–94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Maron BJ. Hypertrophic cardiomyopathy: a systematic review [review]. JAMA. 2002;287:1308–20.

    PubMed  Google Scholar 

  69. Maraj S, Jacobs LE, Maraj R, Contreras R, Rerkpattanapipat P, Malik TA, et al. Inducible left ventricular outflow tract gradient during dobutamine stress echocardiography: an association with intraoperative hypotension but not a contraindication to liver transplantation. Echocardiography. 2004;21:681–5.

    Article  PubMed  Google Scholar 

  70. Rigopoulos AG, Panou F, Kremastinos DT, Seggewiss H. Alcohol septal ablation in hypertrophic obstructive cardiomyopathy [review]. Hell J Cardiol. 2009;50:511–22.

    Google Scholar 

  71. Paramesh AS, Fairchild RB, Quinn TM, Leya F, George M, Van Thiel DH. Amelioration of hypertrophic cardiomyopathy using nonsurgical septal ablation in a cirrhotic patient prior to liver transplantation. Liver Transpl. 2005;11:236–8.

    Article  PubMed  Google Scholar 

  72. Hage FG, Bravo PE, Zoghbi GJ, Bynon JS, Aqel RA. Hypertrophic obstructive cardiomyopathy in liver transplant patients. Cardiol J. 2008;15:74–9.

    PubMed  Google Scholar 

  73. Lim YC, Doblar DD, Frenette L, Fan PH, Poplawski S, Nanda NC. Intraoperative transesophageal echocardiography in orthotopic liver transplantation in a patient with hypertrophic cardiomyopathy. J Clin Anesth. 1995;7:245–9.

    Article  CAS  PubMed  Google Scholar 

  74. Harley ID, Jones EF, Liu G, McCall PR, McNicol PL. Orthotopic liver transplantation in two patients with hypertrophic obstructive cardiomyopathy. Br J Anaesth. 1996;77:675–7.

    Article  CAS  PubMed  Google Scholar 

  75. Cywinski JB, Argalious M, Marks TN, Parker BM. Dynamic left ventricular outflow tract obstruction in an orthotopic liver transplant recipient. Liver Transpl. 2005;11:692–5.

    Article  PubMed  Google Scholar 

  76. Chin JH, Kim YK, Choi DK, Shin WJ, Hwang GS. Aggrevation of mitral regurgitation by calcium administration in a patient with hypertrophic cardiomyopathy during liver transplantation: a case report. Transplant Proc. 2009;41:1979–81.

    Article  CAS  PubMed  Google Scholar 

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  1. Depatment of Anesthesiology, Northwestern Memorial Hospital, Chicago, IL, USA

    Shahriar Shayan MD & Andre M. De Wolf MD

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Correspondence to Andre M. De Wolf MD .

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  1. Department of Anesthesiology, Columbia University Medical Center, New York, New York, USA

    Gebhard Wagener

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Shayan, S., De Wolf, A.M. (2018). The Patient with Severe Co-morbidities: Cardiac Disease. In: Wagener, G. (eds) Liver Anesthesiology and Critical Care Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-64298-7_23

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