Skip to main content

Quality of Life Following Laparoscopic Antireflux Surgery for Primary and Recurrent Gastroesophageal Reflux Disease

  • Chapter
  • First Online:
  • 1048 Accesses

Abstract

Helath-related quality of life (HRQoL) in patients with reflux disease is significantly impaired in comparison to the general population. The level of impairment and types of problems experienced by GERD patients relate to symptom severity, the type and effectiveness of the treatment, sideeffects of surgery, and non-disease related factors such as the presence of other medical conditions, sex or anxiety. Several randomized trials comparing PPI therapy with laparoscopic antireflux surgery have been conducted, particularly over short-medium terms. Based on available studies, it can be concluded that in the short-medium terms laparoscopic antireflux surgery effectively alleviates symptoms of GERD, cures erosive esophagitis and improves quality of life. Postoperative adverse effects are usually mild and patient satisfaction good. For the long term (>10 years), limited data indicate decreasing effectiveness of laparoscopic antireflux surgery. Some patients may revert to the use of PPI therapy, or need revision surgery to improve symptom control following recurrent symptoms. HRQoL of patients with long term treatment success seems to be similar to that of the general population . Failed antireflux surgery and symptom recurrence significantly worsens the QoL in most patients. GERD is prevalent worldwide, and the disease burden seems to be increasing. The range of GERD prevalence estimates are 18.1–27.8% in North America, 8.8–25.9% in Europe, 2.5–7.8% in East Asia, 8.7–33.1% in the Middle East, 11.6% in Australia and 23.0% in South America [1, 2]. Prior use of non-steroidal anti-inflammatory drugs, smoking, excess body weight and gastrointestinal and cardiac conditions are associated with an increased risk of gastro-oesophageal reflux disease [3].

This is a preview of subscription content, log in via an institution.

References

  1. El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014;63(6):871–80.

    Article  PubMed  Google Scholar 

  2. Peery AF, Dellon ES, Lund J, Crockett SD, McGowan CE, Bulsiewicz WJ, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143(5):1179–87.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Ruigomez A, Garcia Rodrıguez LA, Wallander MA, Johansson S, Graffner H, Dent J. Natural history of gastro-oesophageal reflux disease diagnosed in general practice. Aliment Pharmacol Ther. 2004;20:751–60.

    Article  CAS  PubMed  Google Scholar 

  4. Malfertheiner P, Nocon M, Vieth M, Stolte M, Jaspersen D, Koelz HR, Labenz J, Leodolter A, Lind T, Richter K, Willich SN. Evolution of gastro-oesophageal reflux disease over 5 years under routine medical care—the ProGERD study. Aliment Pharmacol Ther. 2012;35(1):154–64.

    Article  CAS  PubMed  Google Scholar 

  5. Peters JH, DeMeester TR, Crookes P, et al. The treatment of gastroesophageal reflux disease with laparoscopic Nissen fundoplication: prospective evaluation of 100 patients with “typical” symptoms. Ann Surg. 1998;228:40–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Mahon D, Rhodes M, Decadt B, Hindmarsh A, Lowndes R, Beckingham I, et al. Randomized clinical trial of laparoscopic Nissen fundoplication compared with proton-pump inhibitors for treatment of chronic gastro-oesophageal reflux. Br J Surg. 2005;92:695–9.

    Article  CAS  PubMed  Google Scholar 

  7. Mehta S, Bennett J, Mahon D, Rhodes M. Prospective trial of laparoscopic Nissen fundoplication versus proton pump inhibitor therapy for gastroesophageal reflux disease: seven-year follow-up. J Gastrointest Surg. 2006;10:1312–7.

    Article  PubMed  Google Scholar 

  8. Grant A, Wileman S, Ramsay C, Bojke L, Epstein D, Sculpher M, et al. The effectiveness and cost-effectiveness of minimal access surgery amongst people with gastro-oesophageal reflux disease—a UK collaborative study. The REFLUX trial. Health Technol Assess. 2008;12(31):1–181.

    Article  CAS  PubMed  Google Scholar 

  9. Grant AM, Wileman SM, Ramsay CR, Mowat NA, Krukowski ZH, Heading RC, et al. Minimal access surgery compared with medical management for chronic gastro-oesophageal reflux disease: UK collaborative randomised trial. BMJ. 2008;337:a2664.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Anvari M, Allen C, Marshall J, Armstrong D, Goeree R, Ungar W, et al. A randomized controlled trial of laparoscopic Nissen fundoplication versus proton pump inhibitors for treatment of patients with chronic gastroesophageal reflux disease: one-year follow-up. Surg Innov. 2006;13:238–49.

    Article  PubMed  Google Scholar 

  11. Anvari M, Allen C, Marshall J, Armstrong D, Goeree R, Ungar W, et al. A randomized controlled trial of laparoscopic Nissen fundoplication versus proton pump inhibitors for the treatment of patients with chronic gastroesophageal reflux disease (GERD): 3-year outcomes. Surg Endosc. 2011;25:2547–54.

    Article  PubMed  Google Scholar 

  12. Attwood SE, Lundell L, Hatlebakk JG, Eklund S, Junghard O, Galmiche JP, et al. Medical or surgical management of GERD patients with Barrett’s Esophagus: the LOTUS trial 3-year experience. J Gastrointest Surg. 2008;12(10):1646–54.

    Article  CAS  PubMed  Google Scholar 

  13. Lundell L, Attwood S, Ell C, Fiocca R, Galmiche JP, Hatlebakk J, et al. Comparing laparoscopic antireflux surgery with esomeprazole in the management of patients with chronic gastro-oesophageal reflux disease: a 3-year interim analysis of the LOTUS trial. Gut. 2008;57(9):1207–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Anvari M, Allen C. Five-year comprehensive outcomes evaluation in 181 patients after laparoscopic Nissen fundoplication. J Am Coll Surg. 2003;196(1):51–7.

    Article  PubMed  Google Scholar 

  15. Galmiche JP, Hatlebakk JG, Attwood SE, Ell C, Fiocca R, Eklund S, et al. Laparoscopic antireflux surgery vs long-term esomeprazole treatment for chronic GERD. Final results after 5 years of follow up in the LOTUS study. Gastroenterology. 2010;138(5 Suppl):S53.

    Google Scholar 

  16. Galmiche J, Hatlebakk J, Attwood S, Ell C, Fiocca R, Eklund S, et al. Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD. The LOTUS randomized clinical trial. JAMA. 2011;305:1969–77.

    Article  CAS  PubMed  Google Scholar 

  17. Grant AM, Cotton SC, Boachie C, Ramsay CR, Krukowski ZH, Heading RC, et al. Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX). BMJ. 2013;346:f1908.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Grant AM, Boachie C, Cotton SC, Faria R, Bojke L, Epstein DM, et al. Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial). Health Technol Assess. 2013;17(22):1–167.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Sandbu R, Sundbom M. Nationwide survey of long-term results of laparoscopic antireflux surgery in Sweden. Scand J Gastroenterol. 2010;45:15–20.

    Article  PubMed  Google Scholar 

  20. Pope CE II. The quality of life following antireflux surgery. World J Surg. 1992;16:355–8.

    Article  PubMed  Google Scholar 

  21. Irvine EJ. Quality of life assessment in gastro-oesophageal reflux disease. Gut. 2004;53(Suppl 4):iv35–9.

    PubMed  PubMed Central  Google Scholar 

  22. Kulig M, Leodolter A, Vieth M, Schulte E, Jaspersen D, Labenz J, Lind T, Meyer-Sabellek W, Malfertheiner P, Stolte M, Willich SN. Quality of life in relation to symptoms in patients with gastro-oesophageal reflux disease—an analysis based on the PROGERD initiative. Aliment Pharmacol Ther. 2003;18(8):767–76.

    Article  CAS  PubMed  Google Scholar 

  23. Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agréus L, Jablonowski H, Zapardiel J. Impact of gastroesophageal reflux disease on patients’ daily lives: a European observational study in the primary care setting. Health Qual Life Outcomes. 2009;7:60.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Tack J, Becher A, Mulligan C, Johnson DA. Systematic review: the burden of disruptive gastro-oesophageal reflux disease on health-related quality of life. Aliment Pharnmacol Ther. 2012;35(11):1257–66.

    Article  CAS  Google Scholar 

  25. Garg KS, Gurusamy KS. Laparoscopic fundoplication surgery versus medical management for gastro-oesophageal reflux disease (GORD) in adults. Cochrane Database Syst Rev. 2015. https://doi.org/10.1002/14651858.CD003243.pub3.

  26. Lundell L, Bell M, Ruth M. Systematic review: laparoscopic fundoplication for gastroesophageal reflux disease in partial responders to proton pump inhibitors. World J Gastroenterol. 2014;20(3):804–13. https://doi.org/10.3748/wjg.v20.i3.804.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Kamolz T, Granderath FA, Schweiger UM, Pointner R. Laparoscopic Nissen fundoplication in patients with nonerosive reflux disease. Long-term quality-of-life assessment and surgical outcome. Surg Endosc. 2005;19(4):494–500. Epub 2005 Feb 3.

    Article  CAS  PubMed  Google Scholar 

  28. Broeders JA, Draaisma WA, Bredenoord AJ, Smout AJ, Broeders IA, Gooszen HG. Long-term outcome of Nissen fundoplication in non-erosive and erosive gastro-oesophageal reflux disease. Br J Surg. 2010;97(6):845–52.

    Article  CAS  PubMed  Google Scholar 

  29. Mardani J, Lundell L, Lönroth H, Dalenbäck J, Engström C. Ten-year results of a randomized clinical trial of laparoscopic total fundoplication with or without division of the short gastric vessels. Br J Surg. 2009;96(1):61–5.

    Article  CAS  PubMed  Google Scholar 

  30. Broeders JA, Rijnhart-de Jong HG, Draaisma WA, Bredenoord AJ, Smout AJ, Gooszen HG. Ten-year outcome of laparoscopic and conventional Nissen fundoplication: randomized clinical trial. Ann Surg. 2009;250:698–706.

    Article  PubMed  Google Scholar 

  31. Dallemagne B, Weertz J, Markiewicz S, Dewandre JM, Wahlen C, Monami B, Jehaes C. Clinical results of laparoscopic fundoplication ten years after surgery. Surg Endosc. 2006;20:159–65.

    Article  CAS  PubMed  Google Scholar 

  32. Fein M, Bueter M, Thalheimer A, Pachmayer V, Heimbucher J, Freys SM, Fuchs KH. Ten year outcome of laparoscopic antireflux procedures. J Gastrointest Surg. 2008;12:1893–9.

    Article  CAS  PubMed  Google Scholar 

  33. Gee DW, Andreoli MT, Rattner DW. Measuring the effectiveness of laparoscopic antireflux surgery long-term results. Arch Surg. 2008;143(5):482–7.

    Article  PubMed  Google Scholar 

  34. Sgromo B, Irvine LA, Cuschieri A, Shimi SM. Long-term comparative outcome between laparoscopic total Nissen and Toupet fundoplication: symptomatic relief, patient satisfaction and quality of life. Surg Endosc. 2008;22(4):1048–53. Epub 2007 Nov 20

    Article  CAS  PubMed  Google Scholar 

  35. Kellokumpu I, Voutilainen M, Haglund C, Färkkilä M, Roberts P, Kautiainen H. Quality of life following laparoscopic Nissen fundoplication: assessing short-term and long-term outcomes. World J Gastroenterol. 2013;19(24):3713–914.

    Article  Google Scholar 

  36. Furnée EJ, Draaisma WA, Broeders IA, Gooszen HG. Surgical reintervention after failed antireflux surgery: a systematic review of the literature. J Gastrointest Surg. 2009;13:1539–49.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Dallemagne B, Arenas Sanchez M, Francart D, Perretta S, Weerts J, Markiewicz S, Jehaes C. Long-term results after laparoscopic reoperation for failed antireflux procedures. Br J Surg. 2011;98(11):1581–7. Epub 2011 Jun 28.

    Article  CAS  PubMed  Google Scholar 

  38. Pessaux P, Arnaud JP, Delattre JF, Meyer C, Baulieux J, Monier H. Laparoscopic antireflux surgery: five-year results and beyond in 1340 patients. Arch Surg. 2005;140:946–51.

    Article  PubMed  Google Scholar 

  39. Hunter JG, Smith CD, Branum GD, Waring JP, Trus TL, Cornwell M, et al. Laparoscopic fundoplication failures: patterns of failure and response to fundoplication revision. Ann Surg. 1999;230:595–604.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Smith CD, McClusky DA, Rajad MA, Lederman AB, Hunter JG. When fundoplication fails: redo? Ann Surg. 2005;241(6):861–9.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Grover BT, Kothari SN. Reoperative antireflux surgery. Surg Clin N Am. 2015;95:629–40.

    Article  PubMed  Google Scholar 

  42. Hashimi S, Bremner RM. Complications following surgery for gastroesophageal reflux disease and achalasia. Thorac Surg Clin. 2015;25:485–98.

    Article  PubMed  Google Scholar 

  43. Zhou T, Harnsberger C, Broderick R, Fuchs H, Talamini M, Jacobsen G, et al. Reoperation rates after laparoscopic fundoplication. Surg Endosc. 2015;29(3):510–4.

    Article  CAS  PubMed  Google Scholar 

  44. Stefanidis D, Navarro F, Augenstein VA, et al. Laparoscopic fundoplication takedown with conversion to Roux-en-Y gastric bypass leads to excellent reflux control and quality of life after fundoplication failure. Surg Endosc. 2012;26(12):3521–7.

    Article  PubMed  Google Scholar 

  45. Awais O, Luketich JD, Schuchert MJ, Morse CR, Wilson J, Gooding WE, Landreneau RJ, Pennathur A. Reoperative antireflux surgery for failed fundoplication: an analysis of outcomes in 275 patients. Ann Thorac Surg. 2011;92(3):1083–9.

    Article  PubMed  Google Scholar 

  46. Wilshire CL, Louie BE, Shultz D, Jutric Z, Farivar AS, Aye RW. Clinical outcomes of reoperation for failed antireflux operations. Ann Thorac Surg. 2016;101(4):1290–6.

    Article  PubMed  Google Scholar 

  47. Awais O, Luketich JD, Reddy N, Bianco V, Levy RM, Schuchert MJ, Gooding WE, Crist LR, Landreneau RJ, Pennathur A. Roux-en-Y near esophagojejunostomy for failed antireflux operations: outcomes in more than 100 patients. Ann Thorac Surg. 2014;98(6):1905–11.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ilmo Kellokumpu .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Kellokumpu, I., Sihvo, E. (2018). Quality of Life Following Laparoscopic Antireflux Surgery for Primary and Recurrent Gastroesophageal Reflux Disease. In: Memon, M. (eds) Hiatal Hernia Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-64003-7_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-64003-7_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-64002-0

  • Online ISBN: 978-3-319-64003-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics