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Use of Biologics in the Postoperative Management of Crohn’s Disease

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Treatment of Inflammatory Bowel Disease with Biologics

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Abstract

A significant portion of patients with Crohn’s disease will require surgical resection at some point in their life. Postoperative recurrent Crohn’s disease occurs in the majority of patients and is often clinically silent. Treatment options shown to modestly reduce the risk of clinical and endoscopic recurrence include antibiotics, aminosalicylates, and immunomodulators. Similarly, antitumor necrosis factor agents have been shown to reduce recurrent disease and perhaps alter the natural course of Crohn’s disease. This chapter reviews the burden of postoperative Crohn’s disease recurrence, the impact of various treatment options with a focus on biologic therapy, practical treatment approaches, and lastly avenues for future research.

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Authors and Affiliations

  1. Division of Gastroenterology, Hepatology and Nutrition, UPMC Presbyterian Hospital, Mezzanine Level C Wing, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Benjamin H. Click & Miguel Regueiro

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  1. Benjamin H. Click
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  2. Miguel Regueiro
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Correspondence to Miguel Regueiro .

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Editors and Affiliations

  1. Beth Israel Deaconess Medical Center Center for Inflammatory Bowel Disease, Harvard Medical School, Boston, Massachusetts, USA

    Adam S. Cheifetz

  2. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

    Joseph D. Feuerstein

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Click, B.H., Regueiro, M. (2018). Use of Biologics in the Postoperative Management of Crohn’s Disease. In: Cheifetz, A., Feuerstein, J. (eds) Treatment of Inflammatory Bowel Disease with Biologics . Springer, Cham. https://doi.org/10.1007/978-3-319-60276-9_5

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  • DOI: https://doi.org/10.1007/978-3-319-60276-9_5

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