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Antitumor Necrosis Factor Agents in Crohn’s Disease

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Treatment of Inflammatory Bowel Disease with Biologics

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Abstract

Antitumor necrosis factor (anti-TNF) medications have revolutionized the treatment for Crohn’s disease (CD). The first anti-TNF was approved for CD in 1998, and since then a total of three anti-TNFs are approved by the FDA for use in CD: infliximab, adalimumab, and certolizumab pegol. This chapter will review each anti-TNF with regard to clinical efficacy (induction and maintenance of remission) as well as other key outcomes such as mucosal healing and fistula healing. Additionally this chapter will summarize key differences between the anti-TNFs and review why not all anti-TNFs work to treat CD. Anti-TNF medications have become the standard of care for moderate to severe CD. Understanding the evidence for the various anti-TNFs, as well as the pros and cons of each, is essential for practitioners treating patients with CD.

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Authors and Affiliations

  1. Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, 410 Delaware Street SE, MMC36, Minneapolis, MN, 55455, USA

    Byron P. Vaughn

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  1. Beth Israel Deaconess Medical Center Center for Inflammatory Bowel Disease, Harvard Medical School, Boston, Massachusetts, USA

    Adam S. Cheifetz

  2. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

    Joseph D. Feuerstein

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Vaughn, B.P. (2018). Antitumor Necrosis Factor Agents in Crohn’s Disease. In: Cheifetz, A., Feuerstein, J. (eds) Treatment of Inflammatory Bowel Disease with Biologics . Springer, Cham. https://doi.org/10.1007/978-3-319-60276-9_3

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