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Pathophysiological Insights of Hypertension in Patients with Chronic Kidney Disease

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Resistant Hypertension in Chronic Kidney Disease

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Abstract

Hypertension is a multi-organ disease, and kidneys play a central role in the development of hypertension, although the kidneys are also being a target organ for hypertension-induced damage. The association between hypertension and chronic kidney disease (CKD) is well known. The prevalence of hypertension increases and control of hypertension becomes more difficult as kidney functions decline. Understanding of the pathophysiology of hypertension is critical for the management of hypertension in CKD. However, there are large gaps in our understanding of pathogenesis and treatment of CKD-related hypertension. Basically, high blood pressure is caused by an increase in cardiac output and/or increase of total peripheral resistance. Both can be deteriorated by a variety of different mechanisms in CKD. Sodium retention and extracellular volume expansion are important, but not the only factors contributing to hypertension seen in CKD. Humoral factors such as renin-angiotensin-aldosterone system, endothelin, and non-humoral factors such as mineral bone disorders may also play a major role in the pathogenesis of hypertension in CKD.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Nephrology, Mustafa Kemal University, School of Medicine, Antakya, Hatay, Turkey

    Faruk Turgut & Mustafa Yaprak

  2. Department of Nephrology, MVZ Gelsenkirchen-Buer, Gelsenkirchen, Germany

    Faruk Tokmak

Authors
  1. Faruk Turgut
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  2. Mustafa Yaprak
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  3. Faruk Tokmak
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Corresponding author

Correspondence to Faruk Turgut .

Editor information

Editors and Affiliations

  1. Grigore T. Popa University of Medicine, IaÅŸi, Romania

    Adrian Covic

  2. Department of Medicine, Division of Nephrology, University School of Medicine, Istanbul, Turkey

    Mehmet Kanbay

  3. Section of Nephrology, University of Illinois at Chicago College of Medicine/Advocate Christ Medical Center, Oak Lawn, Illinois, USA

    Edgar V. Lerma

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Turgut, F., Yaprak, M., Tokmak, F. (2017). Pathophysiological Insights of Hypertension in Patients with Chronic Kidney Disease. In: Covic, A., Kanbay, M., Lerma, E. (eds) Resistant Hypertension in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-56827-0_8

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  • DOI: https://doi.org/10.1007/978-3-319-56827-0_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56825-6

  • Online ISBN: 978-3-319-56827-0

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