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Influence of Radiofrequency Electromagnetic Radiation on Magnetic Properties of Magneto-Mechanochemically Synthesized Antitumor Nanocomplex

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Nanophysics, Nanomaterials, Interface Studies, and Applications (NANO 2016)

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Abstract

This chapter studies the influence of radiofrequency electromagnetic radiation in short-wave range of 0.99, 1.41, 1.84, 2.92, 5.09, 7.41, and 42.0 MHz on the magnetic properties of magneto-mechanochemically synthesized (MMCS) antitumor nanocomplex comprising iron oxide nanoparticles and antitumor anthracycline antibiotic doxorubicin. The methods of magnetometry and electron spin resonance (ESR) spectra were used. In experiments with MMCS antitumor nanocomplex, it was found positive correlation between the area of hysteresis loop and electromagnetic field (EMF) frequency and negative correlation between ESR relative intensity and EMF frequency. Magnetic properties of nanocomplex can be interpreted by well-known nonthermal physical effects of eddy current on magnetic resonance in nanostructures. The skin depth depends on EMF frequency. The ESR results agree with well-known fact, that product yield in free radical reaction oscillates with EMF frequency. The interpretation of experimental data on correlation between the frequency (energy) of EMF radiation and magnetic properties of MMCS nanocomplex and concentration of paramagnetic centers in its structure can contribute to personalized treatment of cancer patients.

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References

  1. Thomas R, Park I-K, Jeong YY (2013) Magnetic iron oxide nanoparticles for multimodal imaging and therapy of cancer. Int J Mol Sci 14:15910–15930

    Article  Google Scholar 

  2. Orel V, Shevchenko A, Romanov A et al (2015) Magnetic properties and antitumor effect of nanocomplexes of iron oxide and doxorubicin. Nanomed Nanotech Biol Med 11:47–55

    Article  Google Scholar 

  3. Barnes FS, Greenebaum B (2015) The effects of weak magnetic fields on radical pairs. Bioelectromagnetics 36(1):45–54

    Article  Google Scholar 

  4. Valko M, Rhodes CJ, Moncol J et al (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160:1–40

    Article  Google Scholar 

  5. Pal A, Singh A, Nag TC (2013) Iron oxide nanoparticles and magnetic field exposure promote functional recovery by attenuating free radical-induced damage in rats with spinal cord transection. Int J Nanomedicine 8(1):2259–2272

    Google Scholar 

  6. Orel V, Romanov A, Rykhalskyi O (2016) Antitumor effect of superparamagnetic iron oxide nanoparticles conjugated with doxorubicin during magnetic nanotherapy of Lewis lung carcinoma. Mat-wiss u Werkstofftech 47(2–3):165–171

    Article  Google Scholar 

  7. Gutman EM (1998) Mechanochemistry of materials. Int Science Publishing, Cambridge

    Google Scholar 

  8. Kuramitz H (2009) Magnetic microbead-based electrochemical immunoassays. Anal Bioanal Chem 394(1):61–69

    Article  Google Scholar 

  9. Abdi MS, Ebadzadeh T, Ghaffari A et al (2015) Synthesis of nano-sized spinel (MgAl2O4) from short mechanochemically activated chloride precursors and its sintering behavior. Adv Powder Technol 26:175–179

    Article  Google Scholar 

  10. Baláž P (2008) Mechanochemistry in Nanoscience and Minerals Engineering. Springer, Berlin

    Google Scholar 

  11. Kajdas C (2013) Ch. 11. General approach to mechanochemistry and its relation to tribochemistry. In: Pihtili H (ed) Tribology in engineering. Intech, Croatia, pp 209–240

    Google Scholar 

  12. Fink DG (1989) Electronics engineers’ handbook, 3 Sub edn. McGraw-Hill Inc, New York

    Google Scholar 

  13. Dobbin ZC, Katre AA, Steg AD et al (2014) Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer. Oncotarget 5(18):8750–8764

    Article  Google Scholar 

  14. Bertotti G (1998) Hysteresis in magnetism. Academic Press, San Diego

    Google Scholar 

  15. Hancock BC, Parks M (2000) What is the true solubility advantage for amorphous pharmaceuticals? Pharm Res 17:397–403

    Article  Google Scholar 

  16. Greiner W, Neise L, Stöcker H (1997) Thermodynamics and statistical mechanics. Springer, New York

    MATH  Google Scholar 

  17. Nikolov NA, Orel VE, Smolanka II et al (2008) Apparatus for short-wave moderate inductothermy with increased asymmetry of electromagnetic field “Magnetotherm”. In: Katushev A, Yu D, Spigulis J (eds) NBC 2008 Proceedings. Springer, Berlin, Heidelberg, pp 294–298

    Google Scholar 

  18. Flovik V, Pettersen BH, Wahlstro E (2016) Eddy-current effects on ferromagnetic resonance: spin wave excitations and microwave screening effects. J Appl Phys 119:163903. http://dx.doi.org/10.1063/1.4948302

  19. Kaner EA, Skobov VG (1964) Theory of resonance excitation of weakly decaying electromagnetic waves in metals. J Exp Theor Phys 18(2):419–432

    Google Scholar 

  20. Roduner E (2006) Nanoscopic materials size-dependent phenomena. RSC Publishing, Cambridge

    Google Scholar 

  21. Carrey J, Mehdaoui B, Respaud M (2011) Simple models for dynamic hysteresis loop calculations: Application to hyperthermia optimization. Appl Phys 109:083921. http://dx.doi.org/ 10.1063/1.3551582

  22. Hayt WH, Buck JA (2006) Engineering electromagnetics, 7th edn. McGraw Hill, New York

    Google Scholar 

  23. Durmus Z, Durmus A, Bektay MY (2016) Quantifying structural and electromagnetic interference (EMI) shielding properties of thermoplastic polyurethane–carbon nanofiber/magnetite nanocomposites. J Mater Sci 51(17):8005–8017

    Article  ADS  Google Scholar 

  24. Feher G, Kip AF (1955) Electron spin resonance absorption in metals. I. Experimental. Phys Rev 98:337–348

    Article  ADS  Google Scholar 

  25. Foot CJ (2005) Atomic physics. Oxford University Press, Oxford, United Kingdom

    Google Scholar 

  26. Dyson FJ (1955) Electron spin resonance absorption in metals. II. Theory of electron diffusion and the skin effect. Phys Rev 98:349–359

    Article  ADS  MATH  Google Scholar 

  27. Gazeau F, Bacri JC, Gendron F et al (1998) Magnetic resonance of ferrite nanoparticles: evidence of surface effects. J Magn Magn Mater 186:175–187

    Article  ADS  Google Scholar 

  28. Schweiger A, Jeschke G (2001) Principles of pulse electron paramagnetic resonance. Oxford University Press, Oxford

    Google Scholar 

  29. Buchachenko AL, Berdinsky VL (2002) Electron spin catalysis. Chem Rev 102(3):603–612

    Article  Google Scholar 

  30. Buchachenko AL (2013) Mass-independent isotope effects. J Phys Chem B 117(8):2231–2238

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. National Cancer Institute, 33/43, Lomonosova St., 03022, Kyiv, Ukraine

    V. Orel, O. Rykhalskyi & A. Romanov

  2. G.V. Kurdyumov Institute for Metal Physics, 36, Academican Vernadsky Blvd., 03680, Kyiv, Ukraine

    A. Shevchenko

  3. R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, 45, Vasilkovsky St., 03022, Kyiv, Ukraine

    A. Burlaka & S. Lukin

Authors
  1. V. Orel
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  2. A. Shevchenko
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  3. O. Rykhalskyi
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  4. A. Romanov
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  5. A. Burlaka
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  6. S. Lukin
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Corresponding author

Correspondence to V. Orel .

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Editors and Affiliations

  1. National Academy of Sciences of Ukraine, Institute of Physics, Kiev, Ukraine

    Olena Fesenko

  2. National Academy of Sciences of Ukraine, Institute of Physics, Kiev, Ukraine

    Leonid Yatsenko

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Orel, V., Shevchenko, A., Rykhalskyi, O., Romanov, A., Burlaka, A., Lukin, S. (2017). Influence of Radiofrequency Electromagnetic Radiation on Magnetic Properties of Magneto-Mechanochemically Synthesized Antitumor Nanocomplex. In: Fesenko, O., Yatsenko, L. (eds) Nanophysics, Nanomaterials, Interface Studies, and Applications . NANO 2016. Springer Proceedings in Physics, vol 195. Springer, Cham. https://doi.org/10.1007/978-3-319-56422-7_62

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