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The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma

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Sigma Receptors: Their Role in Disease and as Therapeutic Targets

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 964))

Abstract

The role of sigma 1 receptor (S1R) in glaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease . S1R modulates multiple cellular functions associated with neurodegeneration . These include Ca2+ ion homeostasis, endoplasmic reticulum (ER) and oxidative stress , survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease.

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Authors and Affiliations

  1. Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA

    Barbara Mysona

  2. Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA

    Neil Kansara & Kathryn Bollinger M.D., Ph.D.

  3. The James and Jean Culver Vision Discovery Institute, Augusta, GA, 30912, USA

    Neil Kansara, Jing Zhao & Kathryn Bollinger M.D., Ph.D.

  4. Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA

    Jing Zhao & Kathryn Bollinger M.D., Ph.D.

  5. Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, 30912, USA

    Kathryn Bollinger M.D., Ph.D.

Authors
  1. Barbara Mysona
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  2. Neil Kansara
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  3. Jing Zhao
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  4. Kathryn Bollinger M.D., Ph.D.
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Corresponding author

Correspondence to Kathryn Bollinger M.D., Ph.D. .

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Editors and Affiliations

  1. Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, Georgia, USA

    Sylvia B. Smith

  2. Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland, USA

    Tsung-Ping Su

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Mysona, B., Kansara, N., Zhao, J., Bollinger, K. (2017). The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma. In: Smith, S., Su, TP. (eds) Sigma Receptors: Their Role in Disease and as Therapeutic Targets. Advances in Experimental Medicine and Biology, vol 964. Springer, Cham. https://doi.org/10.1007/978-3-319-50174-1_20

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