Abstract
Blood marrow transplantation (BMT) is a widespread and validated procedure for the treatment of haematological diseases. Progresses in supportive care, the implementation of less toxic conditioning regimens and the biological and clinical advances made in the field of the graft-versus host disease (GVHD), the major complication of allogeneic stem cells transplantation, have led to an improved outcome of BMT in the past two decades (Gooley et al. N Engl J Med 363:2091–101, 2010).
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Abbreviations
- ATG:
-
Anti-thymocyte globulin
- BM:
-
Bone marrow
- BMDW:
-
Bone marrow donors worldwide
- BMT:
-
Blood marrow transplantation
- CB:
-
(Umbilical) cord blood
- CD34:
-
Cluster of differentiation 34
- DLI:
-
Donor lymphocytes infusion
- G-CSF:
-
Granulocytes-colony stimulating factor
- GVHD:
-
Graft-versus-host disease
- GVL:
-
Graft-versus-leukaemia
- GVT:
-
Graft-versus-tumour
- HLA:
-
Human leukocytes antigens
- IL-1:
-
Interleukin-1
- KIR:
-
Killer immunoglobulin-like receptors
- MAC:
-
Myeloablative conditioning
- MHC:
-
Major histocompatibility complex
- MUD:
-
Matched unrelated donor
- NK:
-
Natural killer
- NRM:
-
Non-relapsed mortality
- PBSC:
-
Peripheral blood stem cells
- PCR:
-
Polymerase chain reaction
- RIC:
-
Reduced intensity conditioning
- STR:
-
Short tandem repeat
- TBI:
-
Total body irradiation
- TNFα:
-
Tumour necrosis factor-alpha
- TRM:
-
Transplant-related mortality
References
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Boncompagni, R., Peris, A. (2018). Blood Marrow Transplantation. In: Esquinas, A., Pravinkumar, S., SOUBANI, A. (eds) Mechanical Ventilation in Critically Ill Cancer Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-49256-8_6
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DOI: https://doi.org/10.1007/978-3-319-49256-8_6
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