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Novel Strategies to Prevent, Mitigate or Reverse Radiation Injury and Fibrosis

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Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

Abstract

Despite recent advances in Radiation Oncology with treatment planning and delivery of image-guided radiation therapy, acute tissue toxicity is still a dose-limiting factor for optimal local tumor control. Additionally, as the number of long-term cancer survivors is increasing, unacceptable complications emerge and dramatically impair the patients’ quality of life. This means patients and clinicians expect therapeutic management of radiation-induced complications. Over the past four decades, research has enhanced our understanding of the pathophysiological, cellular and molecular processes governing normal tissue toxicity. This knowledge has provided us with tools to improve the therapeutic ratio of radiation therapy by enhancing its tumoricidal effect and protecting normal tissue. In this chapter, we review biology-driven efforts to develop translatable therapeutic approaches to prevent, mitigate or reverse radiation injury based upon cellular and signalling pathways targeting. We also highlight innovative approaches based upon manipulating external contributors such as the microbiota and applying novel radiotherapy delivery procedures.

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Authors and Affiliations

  1. Laboratoire de Radio-Oncologie, Centre Hospitalier Universitaire Vaudois, Lausanne, 1011, Switzerland

    Pierre Montay-Gruel, Gael Boivin & Marie-Catherine Vozenin

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  1. Pierre Montay-Gruel
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  2. Gael Boivin
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  3. Marie-Catherine Vozenin
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Correspondence to Marie-Catherine Vozenin .

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Editors and Affiliations

  1. Department of Radiation Oncology Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA

    Mitchell S. Anscher

  2. Department of Radiation Oncology Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA

    Kristoffer Valerie

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Montay-Gruel, P., Boivin, G., Vozenin, MC. (2016). Novel Strategies to Prevent, Mitigate or Reverse Radiation Injury and Fibrosis. In: Anscher, M., Valerie, K. (eds) Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment. Springer, Cham. https://doi.org/10.1007/978-3-319-45594-5_4

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