Skip to main content

Combining Deep Learning and Structured Prediction for Segmenting Masses in Mammograms

  • Chapter
  • First Online:
Deep Learning and Convolutional Neural Networks for Medical Image Computing

Abstract

The segmentation of masses from mammogram is a challenging problem because of their variability in terms of shape, appearance and size, and the low signal-to-noise ratio of their appearance. We address this problem with structured output prediction models that use potential functions based on deep convolution neural network (CNN) and deep belief network (DBN). The two types of structured output prediction models that we study in this work are the conditional random field (CRF) and structured support vector machines (SSVM). The label inference for CRF is based on tree re-weighted belief propagation (TRW) and training is achieved with the truncated fitting algorithm; whilst for the SSVM model, inference is based upon graph cuts and training depends on a max-margin optimization. We compare the results produced by our proposed models using the publicly available mammogram datasets DDSM-BCRP and INbreast, where the main conclusion is that both models produce results of similar accuracy, but the CRF model shows faster training and inference. Finally, when compared to the current state of the art in both datasets, the proposed CRF and SSVM models show superior segmentation accuracy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer statistics, 2008. CA Cancer J Clin 58(2):71–96

    Article  Google Scholar 

  2. Yuan Y, Giger ML, Li H, Suzuki K, Sennett C (2007) A dual-stage method for lesion segmentation on digital mammograms. Med Phys 34:4180

    Article  Google Scholar 

  3. Rahmati P, Adler A, Hamarneh G (2012) Mammography segmentation with maximum likelihood active contours. Med Image Anal 16(6):1167–1186

    Article  Google Scholar 

  4. Beller M, Stotzka R, Müller TO, Gemmeke H (2005) An example-based system to support the segmentation of stellate lesions. In: Bildverarbeitung für die Medizin 2005. Springer, Berlin, pp 475–479

    Google Scholar 

  5. Elmore JG, Jackson SL, Abraham L, Miglioretti DL, Carney PA, Geller BM, Yankaskas BC, Kerlikowske K, Onega T, Rosenberg RD et al (2009) Variability in interpretive performance at screening mammography and radiologists characteristics associated with accuracy1. Radiology 253(3):641–651

    Article  Google Scholar 

  6. Moreira IC, Amaral I, Domingues I, Cardoso A, Cardoso MJ, Cardoso JS (2012) Inbreast: toward a full-field digital mammographic database. Acad Radiol 19(2):236–248

    Article  Google Scholar 

  7. Heath M, Bowyer K, Kopans D, Moore R, Kegelmeyer P (2000) The digital database for screening mammography. In: Proceedings of the 5th international workshop on digital mammography. pp 212–218

    Google Scholar 

  8. Fenton JJ, Taplin SH, Carney PA, Abraham L, Sickles EA, D’Orsi C, Berns EA, Cutter G, Hendrick RE, Barlow WE et al (2007) Influence of computer-aided detection on performance of screening mammography. N Engl J Med 356(14):1399–1409

    Article  Google Scholar 

  9. Dhungel N, Carneiro G, Bradley AP (2015) Deep structured learning for mass segmentation from mammograms. In: 2015 IEEE international conference on image processing (ICIP). pp 2950–2954

    Google Scholar 

  10. Dhungel N, Carneiro G, Bradley AP (2015) Tree re-weighted belief propagation using deep learning potentials for mass segmentation from mammograms. In: 2015 IEEE 12th international symposium on biomedical imaging (ISBI). pp 760–763

    Google Scholar 

  11. Carneiro G, Georgescu B, Good S, Comaniciu D (2008) Detection and measurement of fetal anatomies from ultrasound images using a constrained probabilistic boosting tree. IEEE Trans Med Imaging 27(9):1342–1355

    Article  Google Scholar 

  12. Domke J (2013) Learning graphical model parameters with approximate marginal inference. arXiv preprint arXiv:1301.3193

  13. Tsochantaridis I, Joachims T, Hofmann T, Altun Y (2005) Large margin methods for structured and interdependent output variables. J Mach Learn Res 1453–1484

    Google Scholar 

  14. Krizhevsky A, Sutskever I, Hinton GE (2012) Imagenet classification with deep convolutional neural networks. In: NIPS, vol 1. p 4

    Google Scholar 

  15. LeCun Y, Bengio Y (1995) Convolutional networks for images, speech, and time series. In: The handbook of brain theory and neural networks, vol 3361

    Google Scholar 

  16. Hinton GE, Salakhutdinov RR (2006) Reducing the dimensionality of data with neural networks. Science 313(5786):504–507

    Article  MathSciNet  MATH  Google Scholar 

  17. Wang C, Komodakis N, Paragios N (2013) Markov random field modeling, inference and learning in computer vision and image understanding: A survey. Comput Vis Image Underst 117(11):1610–1627

    Article  Google Scholar 

  18. Wainwright MJ, Jaakkola TS, Willsky AS (2003) Tree-reweighted belief propagation algorithms and approximate ml estimation by pseudo-moment matching. In: Workshop on artificial intelligence and statistics. Society for artificial intelligence and statistics Np, vol 21. p. 97

    Google Scholar 

  19. Boykov Y, Veksler O, Zabih R (2001) Fast approximate energy minimization via graph cuts. IEEE Trans Pattern Anal Mach Intell 23(11):1222–1239

    Article  Google Scholar 

  20. Szummer M, Kohli P, Hoiem D (2008) Learning CRFS using graph cuts. In: Computer vision–ECCV 2008. Springer, Berlin, pp 582–595

    Google Scholar 

  21. Catarious DM Jr, Baydush AH, Floyd CE Jr (2004) Incorporation of an iterative, linear segmentation routine into a mammographic mass cad system. Med Phys 31(6):1512–1520

    Article  Google Scholar 

  22. Song E, Jiang L, Jin R, Zhang L, Yuan Y, Li Q (2009) Breast mass segmentation in mammography using plane fitting and dynamic programming. Acad Radiol 16(7):826–835

    Article  Google Scholar 

  23. Timp S, Karssemeijer N (2004) A new 2d segmentation method based on dynamic programming applied to computer aided detection in mammography. Med Phys 31(5):958–971

    Article  Google Scholar 

  24. Domínguez AR, Nandi AK (2009) Toward breast cancer diagnosis based on automated segmentation of masses in mammograms. Pattern Recognit 42(6):1138–1148

    Google Scholar 

  25. Yu M, Huang Q, Jin R, Song E, Liu H, Hung C-C (2012) A novel segmentation method for convex lesions based on dynamic programming with local intra-class variance. In: Proceedings of the 27th annual ACM symposium on applied computing. ACM, New York, pp 39–44

    Google Scholar 

  26. Xu S, Liu H, Song E (2011) Marker-controlled watershed for lesion segmentation in mammograms. J Digital Imaging 24(5):754–763

    Article  Google Scholar 

  27. Ball J, Bruce L (2007) Digital mammographic computer aided diagnosis (CAD) using adaptive level set segmentation. In: 29th annual international conference of the IEEE engineering in medicine and biology society, 2007. EMBS 2007. IEEE, New York, pp 4973–4978

    Google Scholar 

  28. te Brake GM, Karssemeijer N, Hendriks JH (2000) An automatic method to discriminate malignant masses from normal tissue in digital mammograms. Phys Med Biol 45(10):2843

    Article  Google Scholar 

  29. Sahiner B, Chan H-P, Petrick N, Helvie MA, Hadjiiski LM (2001) Improvement of mammographic mass characterization using spiculation measures and morphological features. Med Phys 28(7):1455–1465

    Article  Google Scholar 

  30. Sethian JA (1999) Level set methods and fast marching methods: evolving interfaces in computational geometry, fluid mechanics, computer vision, and materials science, vol 3. Cambridge University Press, Cambridge

    Google Scholar 

  31. Shi J, Sahiner B, Chan H-P, Ge J, Hadjiiski L, Helvie MA, Nees A, Wu Y-T, Wei J, Zhou C et al (2007) Characterization of mammographic masses based on level set segmentation with new image features and patient information. Med Phys 35(1):280–290

    Article  Google Scholar 

  32. Nowozin S, Lampert CH (2011) Structured learning and prediction in computer vision. Found Trends® Comput Graph Vis 6(3–4):185–365

    MATH  Google Scholar 

  33. Meltzer T, Globerson A, Weiss Y (2009) Convergent message passing algorithms: a unifying view. In: Proceedings of the twenty-fifth conference on uncertainty in artificial intelligence, AUAI Press, pp 393–401

    Google Scholar 

  34. Dempster AP, Laird NM, Rubin DB (1977) Maximum likelihood from incomplete data via the EM algorithm. J R Stat Soc Ser B (Methodol), 1–38

    Google Scholar 

  35. Cardoso JS, Domingues I, Oliveira HP (2014) Closed shortest path in the original coordinates with an application to breast cancer. Int J Pattern Recognit Artif Intell

    Google Scholar 

Download references

Acknowledgements

This work was partially supported by the Australian Research Council’s Discovery Projects funding scheme (project DP140102794). Prof. Bradley is the recipient of an Australian Research Council Future Fellowship(FT110100623).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Neeraj Dhungel .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Dhungel, N., Carneiro, G., Bradley, A.P. (2017). Combining Deep Learning and Structured Prediction for Segmenting Masses in Mammograms. In: Lu, L., Zheng, Y., Carneiro, G., Yang, L. (eds) Deep Learning and Convolutional Neural Networks for Medical Image Computing. Advances in Computer Vision and Pattern Recognition. Springer, Cham. https://doi.org/10.1007/978-3-319-42999-1_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-42999-1_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42998-4

  • Online ISBN: 978-3-319-42999-1

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics