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Formulating Poorly Water Soluble Drugs pp 609–689Cite as

Precipitation Technologies for Nanoparticle Production

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Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 22))

Abstract

Precipitation technologies have been widely studied for nanoparticle production because they provide more control over particle size, shape, and morphology as compared to mechanical processes, such as milling and homogenization. Several precipitation processes are discussed in this chapter, with special attention to experimental parameters and typical particle attributes. The chapter also touches on novel nanoparticle recovery techniques that may be coupled with precipitation processes to enable these precipitation technologies to be scaled for commercial applications. The current authors would like to thank and acknowledge the significant contribution of the previous authors of this chapter from the first edition. This current second edition chapter is a revision and update of the original authors’ work.

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Notes

  1. 1.

    CREMPHOR EL is a registered trademark of BASF Corporation.

  2. 2.

    TAXOL (paclitaxel) is a registered trademark of Bristol-Myers Squibb Company.

  3. 3.

    SPORANOX IV is a registered trademark of Janssen Pharmaceutical Products, LP.

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  1. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 1 University Station A1920, Austin, TX, 78712-0231, USA

    Julien Maincent & Robert O. Williams III

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  1. Julien Maincent
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  2. Robert O. Williams III
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  1. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA

    Robert O. Williams III

  2. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA

    Alan B. Watts

  3. DisperSol Technologies, LLC, Georgetown, Texas, USA

    Dave A. Miller

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Maincent, J., Williams, R.O. (2016). Precipitation Technologies for Nanoparticle Production. In: Williams III, R., Watts, A., Miller, D. (eds) Formulating Poorly Water Soluble Drugs. AAPS Advances in the Pharmaceutical Sciences Series, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-319-42609-9_12

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