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Vitamin D in Chronic Kidney Disease pp 423–441Cite as

Vitamin D in Kidney Transplantation

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Abstract

Renal transplantation restores renal functional mass and corrects metabolic and hormonal disturbances underlying the altered vitamin D metabolism in chronic kidney disease. As a consequence, concentrations of 1,25 dihydroxyvitamin D rapidly recover after successful renal transplantation. Remarkably however, concentrations remain often at the lower range in the early posttransplant period despite the presence of hyperparathyroidism and hypophosphatemia, conditions known to stimulate increased calcitriol synthesis. Also 25-hydroxyvitamin D concentrations increase following transplantation but, overall, these increases are modest. 25-hydroxyvitamin D deficiency and insufficiency thus remain very common among renal transplant recipients. Hypovitaminosis D may contribute to persistent hyperparathyroidism and posttransplant bone and vascular disease. Limited epidemiological evidence also suggest that hypovitaminosis D may foster malignancies and infections in renal transplant recipients. Disappointingly, intervention studies with vitamin D supplementations studies are scanty. They moreover did not yield unequivocal results. Hard endpoint intervention studies are lacking at all.

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Acknowledgements

The author thanks D. Vanderschueren, MD, PhD and S. Pauwels, MD for critical reading of the manuscript.

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  1. Division of Nephrology, Dialysis and Renal Transplantation, Department of Medicine, University Hospital Leuven, Leuven, Belgium

    Pieter Evenepoel MD

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  1. Pieter Evenepoel MD
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Correspondence to Pieter Evenepoel MD .

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  1. Ramsay-Générale de Santé, Clinique du Landy, Saint Ouen, France

    Pablo A. Ureña Torres

  2. San Paolo Hospital, DiSS University of Milan, Milan, Italy

    Mario Cozzolino

  3. VU University Medical Center, Amsterdam, The Netherlands

    Marc G. Vervloet

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Evenepoel, P. (2016). Vitamin D in Kidney Transplantation. In: Ureña Torres, P., Cozzolino, M., Vervloet, M. (eds) Vitamin D in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-32507-1_25

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  • DOI: https://doi.org/10.1007/978-3-319-32507-1_25

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