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Gold Nanoparticle-Based Laser Photothermal Therapy

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Handbook of Thermal Science and Engineering

Abstract

Laser photothermal therapy using gold nanoparticles in cancer research has attracted a lot of attentions in past decades, since it provides an alternative approach to traditional hyperthermia methods. This review is focused on advancements in gold nanoparticle development and the underlying mechanisms to confine heat generation in tumors when these nanoparticles interact with an incident laser. First, an overview of hyperthermia used in medicine is given, and the development of gold nanoparticles in laser photothermal therapy is discussed. Second, physical mechanisms in generating heat utilizing gold nanoparticles, nanoparticle delivery, and toxicity reaction after injection are described. The next section is focused on evaluation of performance of laser photothermal therapy in clinical/animal studies. Monte Carlo methods are presented to demonstrate current theoretical simulation approaches to determine laser energy absorption distribution in tissue enhanced by gold nanoparticles. Furthermore, modeling heat transfer and assessing thermal damage in biological tissue using gold nanoparticles in designing treatment protocols are described to show a typical designing process. At the end of this review, the current challenges facing clinicians and researchers in delivering effective and safe thermal dosage in laser photothermal therapy are discussed.

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Acknowledgment

This work was supported by an NSF grant (CBET-1335958).

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Authors and Affiliations

  1. Department of Mechanical Engineering, University of Minnesota at Minneapolis, Minneapolis, MN, 55455, USA

    Navid Manuchehrabadi

  2. Department of Mechanical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA

    Liang Zhu

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  1. Navid Manuchehrabadi
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Correspondence to Liang Zhu .

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Editors and Affiliations

  1. Department of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA

    Francis A. Kulacki

Section Editor information

  1. Politecnica/COPPE, Universidade Federal do Rio de Janeiro,, Rio de Janeiro, Brasília, Brazil

    Renato Cotta

  2. Department of Mechanical Engineering, University of California, Riverside, California, USA

    Kambiz Vafai

  3. Herff College of Engineering, The University of Memphis, Memphis, Tennessee, USA

    Sumanta Acharya

  4. Gas Technology Institute, Illinois, Illinois, USA

    Yaroslav Chudnovsky

  5. Rm 8260, University of Toronto, Toronto, Ontario, Canada

    Javad Mostaghimi

  6. Cekmeköy Campus, Özyegin University, Çekmeköy - Istanbul, Turkey

    Pinar Mengüc

  7. Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, California, USA

    Vijay K. Dhir

  8. Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, Louisiana, USA

    Ram Devireddy

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Manuchehrabadi, N., Zhu, L. (2017). Gold Nanoparticle-Based Laser Photothermal Therapy. In: Kulacki, F. (eds) Handbook of Thermal Science and Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-32003-8_69-1

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