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Pathology and Classification of Cystic Tumors of the Pancreas: Epidemiology

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Abstract

Cystic tumors of the pancreas are rare, but attract increasing interest as their prognosis is good and the disease is very often curable. One of the most interesting questions dealing with pancreatic cystic tumors remains, whether they appear more frequently in the last decades or the diagnostic tools improved in such a way that they are more frequently diagnosed and classified. As cystic tumors were diagnosed earlier, their resection rate also increased accordingly, allowing a detailed histopathological classification of the tumors. This led to a more precise pathomorphological description and a better classification of cystic pancreatic tumors. In this book chapter, we will give an overview of epidemiological data for the most common cystic pancreatic tumors.

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References

  1. Khan S, Sclabas G, Reid-Lombardo KM. Population-based epidemiology, risk factors and screening of intraductal papillary mucinous neoplasm patients. World J Gastrointest Surg. 2010;2(10):314–8.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Salvia R, et al. Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection. Ann Surg. 2004;239(5):678–85; discussion 685–7.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Marchegiani G, et al. IPMN involving the main pancreatic duct: biology, epidemiology, and long-term outcomes following resection. Ann Surg. 2015;261:976–83.

    Article  PubMed  Google Scholar 

  4. Yoon WJ, et al. Cystic neoplasms of the exocrine pancreas: an update of a nationwide survey in Korea. Pancreas. 2008;37(3):254–8.

    Article  PubMed  Google Scholar 

  5. Le H, et al. A population-based, descriptive analysis of malignant intraductal papillary mucinous neoplasms of the pancreas. Cancer Epidemiol Biomarkers Prev. 2008;17(10):2737–41.

    Article  PubMed  Google Scholar 

  6. Rezaee N, et al. Smoking is not associated with severe dysplasia or invasive carcinoma in resected intraductal papillary mucinous neoplasms. J Gastrointest Surg. 2015;19:656–65.

    Article  PubMed  Google Scholar 

  7. Roch AM, et al. Abnormal serum pancreatic enzymes, but not pancreatitis, are associated with an increased risk of malignancy in patients with intraductal papillary mucinous neoplasms. Surgery. 2014;156(4):923–9.

    Article  PubMed  Google Scholar 

  8. Sturm EC, et al. Obesity increases malignant risk in patients with branch-duct intraductal papillary mucinous neoplasm. Surgery. 2013;154(4):803–8; discussion 808–9.

    Article  PubMed  Google Scholar 

  9. Capurso G, et al. Risk factors for intraductal papillary mucinous neoplasm (IPMN) of the pancreas: a multicentre case-control study. Am J Gastroenterol. 2013;108(6):1003–9.

    Article  PubMed  Google Scholar 

  10. Sugiyama M, Atomi Y. Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol. 1999;94(2):470–3.

    Article  CAS  PubMed  Google Scholar 

  11. Kamisawa T, et al. Malignancies associated with intraductal papillary mucinous neoplasm of the pancreas. World J Gastroenterol. 2005;11(36):5688–90.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Choi MG, et al. High incidence of extrapancreatic neoplasms in patients with intraductal papillary mucinous neoplasms. Arch Surg. 2006;141(1):51–6; discussion 56.

    Article  PubMed  Google Scholar 

  13. Riall TS, et al. Incidence of additional primary cancers in patients with invasive intraductal papillary mucinous neoplasms and sporadic pancreatic adenocarcinomas. J Am Coll Surg. 2007;204(5):803–13; discussion 813–4.

    Article  PubMed  Google Scholar 

  14. Baumgaertner I, et al. Prevalence of extrapancreatic cancers in patients with histologically proven intraductal papillary mucinous neoplasms of the pancreas: a case-control study. Am J Gastroenterol. 2008;103(11):2878–82.

    Article  PubMed  Google Scholar 

  15. Reid-Lombardo KM, et al. Frequency of extrapancreatic neoplasms in intraductal papillary mucinous neoplasm of the pancreas: implications for management. Ann Surg. 2010;251(1):64–9.

    Article  PubMed  Google Scholar 

  16. Marchegiani G, et al. Association between pancreatic IPMNs and extra-pancreatic malignancies. Clin Gastroenterol Hepatol. 2015;13(6):1162–9.

    Article  PubMed  Google Scholar 

  17. Reid-Lombardo KM, et al. Incidence, prevalence, and management of intraductal papillary mucinous neoplasm in Olmsted County, Minnesota, 1984–2005: a population study. Pancreas. 2008;37(2):139–44.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Gil E, et al. Mucinous cystic neoplasms of the pancreas with ovarian stroma. ANZ J Surg. 2013;83(12):985–90.

    Article  PubMed  Google Scholar 

  19. Testini M, et al. Management of mucinous cystic neoplasms of the pancreas. World J Gastroenterol. 2010;16(45):5682–92.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Reddy S, et al. Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional series. J Am Coll Surg. 2009;208(5):950–7; discussion 957–9.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Crippa S, et al. Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients. Ann Surg. 2008;247(4):571–9.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Murakami Y, et al. Intraductal papillary-mucinous neoplasms and mucinous cystic neoplasms of the pancreas differentiated by ovarian-type stroma. Surgery. 2006;140(3):448–53.

    Article  PubMed  Google Scholar 

  23. Yamao K, et al. Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma: a multi-institutional study of the Japan pancreas society. Pancreas. 2011;40(1):67–71.

    Article  CAS  PubMed  Google Scholar 

  24. Kargozaran H, et al. Invasive IPMN and MCN: same organ, different outcomes? Ann Surg Oncol. 2011;18(2):345–51.

    Article  PubMed  Google Scholar 

  25. Crippa S, et al. Mucin-producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics. Clin Gastroenterol Hepatol. 2010;8(2):213–9.

    Article  PubMed  Google Scholar 

  26. Le Borgne J, de Calan L, Partensky C. Cystadenomas and cystadenocarcinomas of the pancreas: a multiinstitutional retrospective study of 398 cases. French Surgical Association. Ann Surg. 1999;230(2):152–61.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Tseng JF, et al. Serous cystadenoma of the pancreas: tumor growth rates and recommendations for treatment. Ann Surg. 2005;242(3):413–9; discussion 419–21.

    PubMed  PubMed Central  Google Scholar 

  28. Chatelain D, et al. Macrocystic form of serous pancreatic cystadenoma. Am J Gastroenterol. 2002;97(10):2566–71.

    Article  PubMed  Google Scholar 

  29. Valsangkar NP, et al. 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital. Surgery. 2012;152(3 Suppl 1):S4–12.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Cui ML, et al. Incidence, risk factors and clinical course of pancreatic fluid collections in acute pancreatitis. Dig Dis Sci. 2014;59(5):1055–62.

    Article  PubMed  Google Scholar 

  31. Park JK, et al. Natural history and malignant risk factors of solid pseudopapillary tumors of the pancreas. Postgrad Med. 2013;125(2):92–9.

    Article  PubMed  Google Scholar 

  32. Cai H, et al. Solid-pseudopapillary neoplasms of the pancreas: clinical and pathological features of 33 cases. Surg Today. 2013;43(2):148–54.

    Article  CAS  PubMed  Google Scholar 

  33. Lin MY, Stabile BE. Solid pseudopapillary neoplasm of the pancreas: a rare and atypically aggressive disease among male patients. Am Surg. 2010;76(10):1075–8.

    PubMed  Google Scholar 

  34. Estrella JS, et al. Solid pseudopapillary neoplasm of the pancreas: clinicopathologic and survival analyses of 64 cases from a single institution. Am J Surg Pathol. 2014;38(2):147–57.

    Article  PubMed  Google Scholar 

  35. Yu PF, et al. Solid pseudopapillary tumor of the pancreas: a review of 553 cases in Chinese literature. World J Gastroenterol. 2010;16(10):1209–14.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Kim CW, et al. Solid pseudopapillary tumor of the pancreas: can malignancy be predicted? Surgery. 2011;149(5):625–34.

    Article  PubMed  Google Scholar 

  37. Manuballa V, Amin M, Cappell MS. Clinical presentation and comparison of surgical outcome for segmental resection vs. Whipple’s procedure for solid pseudopapillary tumor: report of six new cases & literature review of 321 cases. Pancreatology. 2014;14(1):71–80.

    Article  PubMed  Google Scholar 

  38. Cecka F, et al. Solid pseudopapillary tumour of the pancreas: diagnosis, treatment, and prognosis. Acta Chir Belg. 2014;114(1):58–62.

    CAS  PubMed  Google Scholar 

  39. Speer AL, et al. Solid pseudopapillary tumor of the pancreas: a single-institution 20-year series of pediatric patients. J Pediatr Surg. 2012;47(6):1217–22.

    Article  PubMed  Google Scholar 

  40. Guo N, et al. Diagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: analysis of 24 cases. Can J Surg. 2011;54(6):368–74.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Brecht IB, et al. Malignant pancreatic tumors in children and young adults: evaluation of 228 patients identified through the Surveillance, Epidemiology, and End Result (SEER) database. Klin Padiatr. 2011;223(6):341–5.

    Article  CAS  PubMed  Google Scholar 

  42. Barthet M, et al. Management of cysts and pseudocysts complicating chronic pancreatitis. A retrospective study of 143 patients. Gastroenterol Clin Biol. 1993;17(4):270–6.

    CAS  PubMed  Google Scholar 

  43. Ammann RW, et al. Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology. 1984;86(5 Pt 1):820–8.

    CAS  PubMed  Google Scholar 

  44. Elliott DW. Pancreatic pseudocysts. Surg Clin North Am. 1975;55(2):339–62.

    CAS  PubMed  Google Scholar 

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Correspondence to Helmut Friess MD .

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Tieftrunk, E., Ceyhan, G.O., Demir, I.E., Friess, H. (2016). Pathology and Classification of Cystic Tumors of the Pancreas: Epidemiology. In: Del Chiaro, M., Haas, S., Schulick, R. (eds) Cystic Tumors of the Pancreas. Springer, Cham. https://doi.org/10.1007/978-3-319-31882-0_3

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  • DOI: https://doi.org/10.1007/978-3-319-31882-0_3

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