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Therapy for J Wave Syndromes

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J Wave Syndromes

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Abstract

Brugada Syndrome (BrS) and Early Repolarization syndrome (ERS) are most often diagnosed in young and active patients who present management challenges both related to risk stratification (covered in Chap. 8) and to pharmacologic and device-based therapies. Implantable cardiac defibrillators (ICDs) still represent the gold standard for the protection from sudden cardiac arrest (SCA), but their effect is confined to the termination of ventricular tachycardia (VT) and ventricular fibrillation (VF). On the other hand, pharmacological therapies and catheter ablation aim to prevent VT/VF episodes but have their own limitations. This chapter will review specific aspects of pharmacological therapy, lifestyle changes, ICD therapy and catheter ablation.

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Disclosures

Nicolas Derval received speaking honorarium from Medtronic and consulting fees from St Jude Medical.

Pierre Jais received consulting fees and speaking honorarium from Biosense Webster and St Jude Medical. He has stock option from Cardio-Insight.

Meleze Hocini received consulting fees from Medtronic. She has stock option from Cardio-Insight.

Michel Haissaguerre received consulting fees from Biosense Webster. He has stock option from Cardio-Insight.

Frederic Sacher received speaking honorarium from Biosense Webster, Medtronic, St Jude Medical, Sorin Group, Boehringer Ingelheim, Bayer Healthcare, Pfizer, Buchang Pharma; Consulting fees from St Jude Medical, Bayer Healthcare, Sorin Group; Research grant from Medtronic.

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Authors and Affiliations

  1. Cardiology Department, Bordeaux University Hospital, LIRYC Institute, INSERM 1045, Bordeaux, France

    Antonio Frontera MD, Arnaud Denis MD, Nicolas Derval MD, Pierre Jais MD, Meleze Hocini MD, Michel Haissaguerre MD & Frédéric Sacher MD, PhD

  2. Cardiology Department, University of Wisconsin, Madison, WI, USA

    Michael E. Field MD

  3. Genetic Department, Bordeaux University Hospital, LIRYC Institute, INSERM 1045, Bordeaux, France

    Caroline Thambo MD, PhD

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  1. Antonio Frontera MD
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Correspondence to Frédéric Sacher MD, PhD .

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  1. Cardiovascular Research, Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA

    Charles Antzelevitch

  2. Lankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, Pennsylvania, USA

    Gan-Xin Yan

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Frontera, A. et al. (2016). Therapy for J Wave Syndromes. In: Antzelevitch, C., Yan, GX. (eds) J Wave Syndromes. Springer, Cham. https://doi.org/10.1007/978-3-319-31578-2_15

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