Definition
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas constitutes a cystic entity with neoplastic proliferation of mucinous epithelium arising within the ductal system of the pancreas. Unlike pancreatic intraepithelial neoplasia (PanIN), IPMN is macroscopically visible (i.e. >0.5 cm), characteristically presents a papillary architecture and produces varying, mostly plenty, amount of mucin. It may involve the main pancreatic duct (main duct-type), the branching ducts (branch duct-type), or both (mixed-type IPMN) (Hruban and Guler 2010). Together with PanIN, and mucinous cystic neoplasia (MCN), IPMN is a (mucinous) precursor of pancreatic ductal adenocarcinoma (PDAC) (Klimstra et al. 2019). Reflecting the concept of adenoma-carcinoma-sequence, IPMN bears the potential to develop high-grade dysplasia and invasive carcinoma...
References and Further Reading
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Wartenberg, M., Karamitopoulou-Diamantis, E. (2021). Intraductal Papillary Mucinous Neoplasm (IPMN) and IPMN with Associated Invasive Component. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5539-1
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